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作品数：201被引量：605H指数：12
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相关机构：第二军医大学第三军医大学西南医院南京医科大学湖州市第三人民医院更多>>
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Aberrant Hippocampal Development in Early‑onset Mental Disorders and Promising Interventions:Evidence from a Translational Study
《Neuroscience Bulletin》2024年第6期683-694,共12页Jingyu Yang Huiling Guo Aoling Cai Junjie Zheng Juan Liu Yao Xiao Sihua Ren Dandan Sun Jia Duan Tongtong Zhao Jingwei Tang Xizhe Zhang Rongxin Zhu Jie Wang Fei Wang 
supported by the National Science Fund for Distinguished Young Scholars(81725005);the National Natural Science Foundation Regional Innovation and Development Joint Fund(U20A6005);the National Natural Science Foundation of China(82151315 and 62176129);the National Key Research and Development Program(2022YFC2405605);the Jiangsu Provincial Key Research and Development Program(BE2021617 and BE2022160);the Key Project supported by Medical Science and Technology Development Foundation,Jiangsu Commission of Health(ZD2021026);the Jiangsu Funding Program for Excellent Postdoctoral Talent(2023ZB818);the Postdoctoral Research Project of Changzhou Medical Center,Nanjing Medical University(CMCP202305).
Early-onset mental disorders are associated with disrupted neurodevelopmental processes during adolescence.The methylazoxymethanol acetate(MAM)animal model,in which disruption in neurodevelopmental processes is induce...
关键词：EARLY-ONSET Mental disorder NEURODEVELOPMENT Animal model Hippocampus Repetitive transcranial magnetic stimulation 
Inflammatory Factor IL1αInduces Aberrant Astrocyte Proliferation in Spinal Cord Injury Through the Grin2c/Ca^(2+)/CaMK2b Pathway
《Neuroscience Bulletin》2024年第4期421-438,共18页Yu Xia Lu Ding Changlin Zhang Qi Xu Ming Shi Tianshun Gao Feng-Quan Zhou David Y.B.Deng 
supported by the National Natural Science Foundation of China(82071362,82002899);the Basic Research Project of Shenzhen Science and Technology Innovation Commission(JCYJ202205303001577,JCYJ20190809165201646);Basic Research Projects of Shenzhen Science and Technology Program(JCYJ20180307150610733).
Spinal cord injury(SCI)is one of the most devastating traumas,and the aberrant proliferation of astrocytes usually causes neurological deficits.However,the mechanism underlying astrocyte over-proliferation after SCI i...
关键词：IL1α Grin2c ASTROCYTE Spinal cord injury 
Astrocytic Gap Junctions Contribute to Aberrant Neuronal Synchronization in a Mouse Model of MeCP2 Duplication Syndrome
《Neuroscience Bulletin》2022年第6期591-606,共16页Shengnan Xia Hua-Tai Xu 
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB32010100);a National Natural Science Foundation of China project(31671113);a Shanghai Municipal Science and Technology Major Project(2018SHZDZX05);and the State Key Laboratory of Neuroscience.
Abnormal synchronous neuronal activity has been widely detected by brain imaging of autistic patients,but its underlying neural mechanism remains unclear.Compared with wild-type mice,our in vivo two-photon imaging sho...
关键词：Autism spectrum disorder ASTROCYTE Gap junction Neuronal synchrony MeCP2-Slow inward current Neuronal development 
Selective Aberrant Functional–Structural Coupling of Multiscale Brain Networks in Subcortical Vascular Mild Cognitive Impairment被引量：8
《Neuroscience Bulletin》2021年第3期287-297,共11页Juanwei Ma Feng Liu Bingbing Yang Kaizhong Xue Pinxiao Wang Jian Zhou Yang Wang Yali Niu Jing Zhang 
supported by the Natural Science Foundation of Tianjin Municipal Science and Technology Commission(18JCQNJC10900);Tianjin Natural Science Foundation(17JCZDJC36300)。
Subcortical vascular mild cognitive impairment(svMCI)is a common prodromal stage of vascular dementia.Although mounting evidence has suggested abnormalities in several single brain network metrics,few studies have exp...
关键词：Resting-state fMRI Diffusion tensor imaging Functional–structural coupling Modular architecture Subcortical vascular mild cognitive impairment 
P-Rex1 Overexpression Results in Aberrant Neuronal Polarity and Psychosis-Related Behaviors被引量：2
《Neuroscience Bulletin》2019年第6期1011-1023,共13页Qiongwei Li Lifang Wang Yuanlin Ma Weihua Yue Dai Zhang Jun Li 
supported by grants from the National Natural Science Foundation of China (81730037, 81871077, and 81671363);the Beijing Municipal Science and Technology Project (Z181100001518001);the Young Elite Scientists Sponsorship Program By China Association for Science and Technology (YESS20160068)
Neuronal polarity is involved in multiple developmental stages, including cortical neuron migration,multipolar-to-bipolar transition, axon initiation, apical/basal dendrite differentiation, and spine formation. All of...
关键词：P-Rex1 NEURODEVELOPMENT Polarity LAMELLIPODIA Psychosis-related behavior 
Aberrant Resting-State Functional Connectivity in the Default Mode Network in Pediatric Bipolar Disorder Patients with and without Psychotic Symptoms被引量：6
《Neuroscience Bulletin》2019年第4期581-590,共10页Yuan Zhong Chun Wang Weijia Gao Qian Xiao Dali Lu Qing Jiao Linyan Su Guangming Lu 
supported by National Natural Science Foundation of China (81171291, 81371531, 81571344, 81871344);the Natural Science Foundation of Jiangsu Province, China (BK20161109);the Key Program for Guangming Lu (BWS11J063, and 10z026);the Natural Science Foundation of the Higher Education Institutions of Jiangsu Province, China (18KJB190003);the Postdoctoral Science Foundation of China (2014M552700)
Mood disorders/psychosis have been associated with dysfunctions in the default mode network(DMN).However,the relative contributions of DMN regions to state and trait disturbances in pediatric bipolar disorder(PBD)rema...
关键词：Pediatric bipolar DISORDER DEFAULT mode RESTING-STATE fMRI Functional connectivity PSYCHOTIC SYMPTOM 
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