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Reducing off-target effects of DdCBEs by reversing amino acid charge near DNA interaction sites: 《Cell Research》2024年第12期877-881,共5页Long Xie Yaqi Cao Di Li Mengxue Ma Danrong Jiao Hu Feng Zhenrui Zuo Erwei Zuo; Dear Editor,DddA_(tox)-derived cytosine base editors(DdCBEs)can mediate precise,CRISPR-independent editing of mitochondrial DNA(mtDNA),but were recently shown to potentially introduce extensive and non-trivial off-tar...; 关键词：TRIVIAL utilizing PRECISE

The RALF1-FERONIA complex interacts with and activates TOR signaling in response to low nutrients被引量：3: 《Molecular Plant》2022年第7期1120-1136,共17页Limei Song Guoyun Xu Tingting Li Huina Zhou Qinlu Lin Jia Chen Long Wang Dousheng Wu Xiaoxu Li Lifeng Wang Sirui Zhu Feng Yu; supported by grants from the National Natural Science Foundation of China(NSFC-;31900232,31871396,and 31571444);the Natural Science Foundation of Hunan Province(2020JJ5049);the Science and Technology Innovation Program of Hunan Province(2020WK2014,and 2022WK2007);the Key Scientific and Technological Project of Henan Province(212102110446);the China Postdoctoral Science Foundation(2018M642972).; Target of rapamycin(TOR)kinase is an evolutionarily conserved major regulator of nutrient metabolism and organismal growth in eukaryotes.In plants,nutrients are remobilized and reallocated between shoots and roots und...; 关键词：TOR FERON IA nitrogen response amino acid response energy metabolism

ILipo-PseAAC: Identification of Lipoylation Sites Using Statistical Moments and General PseAAC: 《Computers, Materials & Continua》2022年第4期215-230,共16页Talha Imtiaz Baig Yaser Daanial Khan Talha Mahboob Alam Bharat Biswal Hanan Aljuaid Durdana Qaiser Gillani; Lysine Lipoylation is a protective and conserved Post Translational Modification(PTM)in proteomics research like prokaryotes and eukaryotes.It is connected with many biological processes and closely linked with many m...; 关键词：Lipoylation lysine feature vector post translational modification amino acid Mathew’s correlation coefficient neural network

Trimetaphosphate-induced chiral selection between amino acid and nucleoside using ^(15)N-^(31)P coupling NMR被引量：1: 《Chinese Chemical Letters》2022年第2期821-824,共4页Jianxi Ying Ruiwen Ding Yumeng Zhang Bowen Han Yeting Guo Ning Wang Dandan Guo Yile Wu Junwei Huang Yan Liu Feng Ni Shaohua Huang Yufen Zhao; supported by the National Natural Science Foundation of China (Nos.91856126,42003062,21778042 and 41876072);Scientific Research Grant of Ningbo University (No.215432000282);Ningbo Top Talent Project (No.215-432094250)。; Life on Earth uses a common set of L-amino acids(L-aa)to construct proteins and D-nucleosides(D-Nu)to form nucleic acids,which serve as the carrier of genetic information.Herein,we reveal the in-trinsic mechanism of c...; 关键词：Chiral selection Amino acids NUCLEOSIDES Prebiotic chemistry Origin of life

Changing Gly311 to an acidic amino acid in the MATE family protein DTX6 enhances Arabidopsis resistance to the dihydropyridine herbicides被引量：2: 《Molecular Plant》2021年第12期2115-2125,共11页Zeyu Lv Mingming Zhao Wenjing Wang Qi Wang Mengqi Huang Chaoqun Li Qichao Lian Jinqiu Xia Ji Qi Chengbin Xiang Huiru Tang Xiaochun Ge; supported by the Shanghai Science and Technology Innovation Action Plan 18JC1411800;the National Natural Science Foundation of China(grant nos.31770274 and 31970343).; In modern agriculture,frequent application of herbicides may induce the evolution of resistance in plants,but the mechanisms underlying herbicide resistance remain largely unexplored.Here,we report the char-acterizati...; 关键词：PARAQUAT DIQUAT point mutation DTX6 gene function multidrug and toxic compound extrusion

Single-molecule mechanical folding and unfolding kinetics of armless mitochondrial tRNA^(Arg) from Romanomermis culicivorax: 《Chinese Physics B》2021年第10期651-659,共9页Yan-Hui Li Zhen-Sheng Zhong Jie Ma; supported by the Natural Science Foundation of Guangdong Province,China(Grant No.2017A030310085);the Science and Technology Planning Project of Guangdong Province,China(Grant No.2018A050506034).; The mechanical stability of tRNAs contributes to their biological activities.The mitochondrial tRNAArg from Romanomermis culicivorax is the shortest tRNA ever known.This tRNA lacks D-and T-arms,represents a stem-bulge...; 关键词：mitochondrial tRNA mechanical stability singlemolecule manipulation amino acid-chelated Mg^(2+)

Roles of dietary taurine in fish nutrition被引量：2: 《Marine Life Science & Technology》2020年第4期360-375,共16页W.W.H.A.Sampath R.M.D.S.Rathnayake Mengxi Yang Wenbing Zhang Kangsen Mai; Ack no wledgements This study was financially supported by the National Key R&D Program of China(2019YFD0900200);the Key R&D Program of Shandong Province,China(2016CYJS04A01,2017CXGC0105).; Taurine is a conditionally essential amino acid in fish nutrition.The present study addressed the practical application of examining published data on fish nutrition over the past 20 years,emphasizing the topic of tau...; 关键词：TAURINE Fish Amino acid NUTRITION FEED

Exploring novel cell cryoprotectants based on neutral amino acids被引量：2: 《Chinese Journal of Chemical Engineering》2020年第10期2640-2649,共10页Xiaojie Sui Pengguang Chen Chiyu Wen Jing Yang Qingsi Li Lei Zhang; the financial support from the National Natural Science Foundation of China(Nos.21621004,21961132005,21908160 and 21422605);the Qingdao National Laboratory for Marine Science and Technology(QNLM2016ORP0407);the Tianjin Natural Science Foundation(18JCYBJC29500);the China Postdoctoral Science Foundation(2019M651041)。; Cryoprotectants play a key role in cell cryopreservation because they can reduce cryoinjuries to cells associated with ice formation.To meet the clinical requirements of cryopreserved cells,cryoprotectants should be b...; 关键词：Biomedical engineering Cell engineering Tissue engineering CRYOPRESERVATION CRYOPROTECTANT Neutral amino acid

SuccSite:Incorporating Amino Acid Composition and Informative k-spaced Amino Acid Pairs to Identify Protein Succinylation Sites被引量：1: 《Genomics, Proteomics & Bioinformatics》2020年第2期208-219,共12页Hui-Ju Kao Van-Nui Nguyen Kai-Yao Huang Wen-Chi Chang Tzong-Yi Lee; the Warshel Institute for Computational Biology,School of Life and Health Sciences,The Chinese University of Hong Kong,Shenzhen,China for financially supporting this research; Protein succinylation is a biochemical reaction in which a succinyl group(-CO-CH2-CH2-CO-)is attached to the lysine residue of a protein molecule.Lysine succinylation plays important regulatory roles in living cells.H...; 关键词：Protein succinylation Succinyl group Substrate specificity Amino acid composition k-spaced amino acid pair composition

Engineering Plant Cytochrome P450s for Enhanced Synthesis of Natural Products: Past Achievements and Future Perspectives被引量：3: 《Plant Communications》2020年第1期57-63,共7页Yi Shang Sanwen Huang; This work was funded by the National Key Research and Development Program of China(2018YFA0901800);the National Natural Science Foundation of China(31972433);This work was also supported from Yunnan Provincial and Shenzhen Municipal Governments.; Cytochrome P450s(P450s)are the most versatile catalysts and are widely used by plants to synthesize a vast array of structurally diverse specialized metabolites that not only play essential ecological roles but also c...; 关键词：plant cytochrome P450 plant natural product protein engineering amino acid co-evolution protein design

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