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Enhanced oral drug delivery by mimicking natural amino acid and oligopeptide absorption route: 《Nano Research》2025年第2期525-540,共16页Ruinan Wu Xiaoxing Fan Licheng Wu Liyun Xing Jinxia Kong Zhou Zhou Jingyuan Wen Lian Li Yuan Huang; This work was supported by the National Key Research and Development Program of China(No.2021YFE0115200);the Regional Innovation and Development Joint Fund of National Natural Science Foundation of China(No.U22A20356).; Oral delivery of protein and peptide drugs presents considerable challenges due to their susceptibility to digestive enzymes in gastrointestinal(Gl)tract and low efficiency of transepithelial transport.Herein,inspired...; 关键词：oral drug delivery amino acid absorption route oligopeptide absorption route LIRAGLUTIDE

Multidimensional Role of Amino Acid Metabolism in Immune Regulation:From Molecular Mechanisms to Therapeutic Strategies: 《Chemical Research in Chinese Universities》2025年第1期1-14,共14页QIN Changjuan YANG Guanqing WEI Qi XIN Hua DING Jianxun CHEN Xuesi; supported by the National Natural Science Foundation of China(Nos.U23A20591,52273158,and 52203200);the Science and Technology Development Program of Jilin Province,China(Nos.20240101002JJ,20240404010ZP,and YDZJ202402077CXJD);the Youth Talents Promotion Project of Jilin Province,China(No.Y2023066).; Immune cells are essential components of the human immune system,playing a critical role in maintaining human health and defending against diseases.Changes in nutritional metabolism influence the activation,proliferat...; 关键词：Amino acid METABOLISM Dendritic cell T cell IMMUNOMODULATION

Amino acid assisted aqueous synthesis of highly stable CsPbBr_(3)nanocrystals for cell imaging: 《Nano Research》2025年第1期675-683,共9页Xue Li Yanan Guo Guoying Tan Qingyi Liu Nan Song Yu Tang; support from the National Natural Science Foundation of China(Nos.22221001,and 22131007);the Science and Technology Major Plan of Gansu Province(No.23ZDGA012);the 111 project(No.B20027).; Lead halide perovskite nanocrystals(NCs)exhibit excellent optoelectronic performance and have drawn great interests in the fields of biological imaging and sensing.However,the poor stability of CsPbX_(3)(X=Cl,Br,I)in ...; 关键词：aqueous synthesis cell imaging lead halide perovskite nanocrystals L-glutamic acid phase transformation

Direct and rapid detection of serum amino acid and monoamine neurotransmitters to assist the diagnosis of panic disorder: 《Science China Chemistry》2025年第1期377-384,共8页Shiwen Liu Xuerui Wan Meng Zhao Jiaqi Wang Weilan Wu Linlin You Yonggui Yuan Qian Xu Rong Gao; supported by the National Natural Science Foundation of China(82273684)。; The measurement of amino acid and monoamine neurotransmitters(NTs)in serum plays a central role in the identification and monitoring of clinical panic disorder(PD).However,the strong polarity and chemical heterogeneit...; 关键词：NEUROTRANSMITTERS panic disorder magnetic solid phase extraction direct analysis of mass spectrometry in real time

High-level L-Gln compromises intestinal amino acid utilization efficiency and inhibits protein synthesis by GCN2/eIF2a/ATF4 signaling pathway in piglets fed low-crude protein diets: 《Animal Nutrition》2024年第4期480-487,共8页Jun Li Yinfeng Chen Yang Yang Ying Yang Zhenlong Wu; supported by grants from the National Key R&D Program of China(2022YFF1100102,2022YFF1100104,2022YFC2105005);the National Natural Science Foundation of China(No.32172749,31625025).; Gln,one of the most abundant amino acids(AA)in the body,performs a diverse range of fundamental physiological functions.However,information about the role of dietary Gln on AA levels,transporters,protein synthesis,and...; 关键词：L-Gln Low protein diet Weaned piglet Amino acid transporter Protein synthesis GCN2/eIF2a/ATF4 signaling

A plausible pathway to prebiotic peptides via amino acid amides on the primordial Earth: 《Earth and Planetary Physics》2024年第6期868-877,共10页DingWei Gan XiangMin Lei RenWu Zhou SongSen Fu Jing Sun RuSen Zhou Kostya(Ken)Ostrikov YuFen Zhao JianXi Ying; National Natural Science Foundation of China(Nos.42388101,92256203,and 42003062);Fundamental Research Funds for the Provincial Universities of Zhejiang(No.SJLY2023007);Technology and Engineering Center for Space Utilization,Chinese Academy of Sciences(No.YYWT-0901-EXP-16);Ningbo Top Talent Project(No.215-432094250).; The prebiotic synthesis of peptides prior to ribosome-catalyzed processes remains an enigma.The synthesis of abiotic peptides from amino acids(AAs)is primarily constrained by high activation energies and unfavorable t...; 关键词：prebiotic chemistry origin of life chemical evolution PEPTIDE

Dietary protein re-alimentation following restriction improves protein deposition via changing amino acid metabolism and transcriptional profiling of muscle tissue in growing beef bulls: 《Animal Nutrition》2024年第4期117-130,共14页Jiaqi Wang Chun Shen Guangyong Zhao Mark D.Hanigan Mengmeng Li; supported by the National Natural Science Foundation of China(grant no.32102573);the 315 Talent Project at China Agricultural University.; This study aimed to develop a compensatory growth model using growing beef cattle by changing dietary protein and to investigate the underlying mechanisms of compensatory protein deposition in muscle tissue.Twelve Cha...; 关键词：Amino acid Beef cattle Compensatory growth METABOLISM Protein

Reducing off-target effects of DdCBEs by reversing amino acid charge near DNA interaction sites: 《Cell Research》2024年第12期877-881,共5页Long Xie Yaqi Cao Di Li Mengxue Ma Danrong Jiao Hu Feng Zhenrui Zuo Erwei Zuo; Dear Editor,DddA_(tox)-derived cytosine base editors(DdCBEs)can mediate precise,CRISPR-independent editing of mitochondrial DNA(mtDNA),but were recently shown to potentially introduce extensive and non-trivial off-tar...; 关键词：TRIVIAL utilizing PRECISE

Advancing energy storage with nitrogen containing biomaterials utilizing amino acid, peptide and protein: Current trends and future directions: 《Journal of Energy Chemistry》2024年第12期253-276,共24页Madan R.Biradar Harshad A.Mirgane Sidhanath V.Bhosale Sheshanath V.Bhosale; financial support from The Director, CSIR-IICT (MS No. IICT/Pubs./2024/043) Hyderabad, India;University Grant Commission (UGC) Faculty Research Program, New Delhi, India (F.4-5(50-FRP) (IV-Cycle)/2017(BSR)) for an award of Professorship。; As the climate crisis continues to escalate, there has been a growing emphasis on the development of electrode materials that are environmentally friendly and sustainable. Biomolecules, such as proteins,peptides, and ...; 关键词：Amino acid Battery Electrolytes PEPTIDE PROTEIN SUPERCAPACITOR Fuel cell

A cucurbit[8]uril-based supramolecular phosphorescent assembly:Cell imaging and sensing of amino acids in aqueous solution: 《Chinese Chemical Letters》2024年第12期165-168,共4页Qian Ren Xue Dai Ran Cen Yang Luo Mingyang Li Ziyun Zhang Qinghong Bai Zhu Tao Xin Xiao; supported by the National Natural Science Foundation of China(No.22361011);Guizhou Provincial Science and Technology Projects(No.ZK[2023]General 040)。; In recent years,host-guest interactions of macrocycles have emerged as a promising approach to effectively enhance pure organic room-temperature phosphorescence by inhibiting the nonradiative relaxation while isolatin...; 关键词：CUCURBITURIL Isobromoquinoline Pure organic room-temperature PHOSPHORESCENT Cell imaging Amino acid

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