云南高校图书馆联盟文献共享服务平台- ANTI-TUMOR

ANTI-TUMOR: 作品数：366被引量：1036H指数：14; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：李瑞赵浩如林以宁张晗星李彦更多>>; 相关机构：北京大学中国药科大学重庆医科大学山东大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划中国博士后科学基金更多>>

A selective HK2 degrader suppresses SW480 cancer cell growth by degrading HK2: 《Chinese Chemical Letters》2024年第8期201-204,共4页Yang Liu Yan Liu Kaiyin Yang Zhiruo Zhang Wenbo Zhang Bingyou Yang Hua Li Lixia Chen; Chunhui Program-Cooperative Research Project of the Ministry of Education;Liaoning Province Natural Science Foundation (No.2022-MS-241);Shenyang Young and Middle-aged Innovative Talents Support Program (No.RC210446)for financial supports;the support from National-Local Joint Engineering Research Center for Molecular Biotechnology of Fujian&Taiwan TCM;Fujian Key Laboratory of Chinese Materia Medica;Fujian University Key Laboratory for Research and Development of TCM Resources,at Fujian University of Traditional Chinese Medicine; Hexokinase 2(HK2)is the rate-limiting enzyme in the first step of glycolysis,catalyzing glucose to glucose-6-phosphate,and overexpressed in most cancer cells.HK2 also binds to voltage-dependent anion channel(VDAC)to s...; 关键词：HK2 PROTACs Degrader ANTI-TUMOR SW480

Evaluation of erastin synergized cisplatin anti-nasopharyngeal carcinoma effect with a glutathione-activated near-infrared fluorescent probe: 《Chinese Chemical Letters》2024年第2期311-316,共6页Rong He Dandan Tang Ningge Xu Heng Liu Kun Dou Xuejun Zhou Fabiao Yu; supported by the Hainan Province Science and Technology Special Fund(Nos.ZDYF2021SHFZ219,ZDYF2022SHFZ288);National Natural Science Foundation of China(Nos.21961010,22264013,22204037);Hainan Provincial Natural Science Foundation of China(No.822RC831);Natural Science Research Talent Project of Hainan Medical University(No.JBGS202101);Project for Functional Materials and Molecular Imaging Science Innovation Group of Hainan Medical University;Hainan Province Clinical Medical Center(2021).; Nasopharyngeal carcinoma(NPC),a malignant tumor originating from the nasopharynx,is one of the common malignant tumors of the head and neck.There are significant geographical differences in the incidence of nasopharyn...; 关键词：GLUTATHIONE NIRF probe Ferroptosis Anti-tumor therapy evaluation BIOIMAGING

pIL-12 delivered by polymer based nanovector for anti-tumor genetherapy: 《Chinese Chemical Letters》2023年第11期209-213,共5页Lianbin Wen Xin Zan Qidi Pang Yuzhu Hu Songping Zheng Mengni Ran Xiang Gao Xiang Wang Bilan Wang; supported by the National Natural Science Foundation of China(No.81972347);the Key R&D Projects of the Science and Technology Department of Sichuan Province(No.2022YFS0324).; Finding more effective and safe non-viral vectors to transfer genes into cancer cells has become the key of immune gene therapy for cancer.Herein a triblock compound MPEG_(2000)-PDLLA_(4000)-MPEG_(2000) modified by ca...; 关键词：Non-viral vector Cancer gene therapy pIL-12 Immune response NANOCOMPOSITE

In silico design of anti-tumor mini-protein targeting MDM2: 《Chinese Chemical Letters》2023年第5期256-258,共3页Jinghui Zhang Huixin Xu Baishi Wang Xuekai Zhang Lei Fu Yannan Li Guanzhao Wu Zitong Zhao Lu Liu Ting Yang Zheyu Zhang Jinbo Yang Tao Jiang Peiju Qiu Rilei Yu; supported by the National Natural Science Foundation of China(Nos.3217110331 and 8212200560);Major new drug development in Shandong Province(No.2020CXGC010503)。; We designed a disulfide-crosslinked mini-protein with a two-helical topology consisting of L-and Damino acids,which was exceptionally stable in serum.Therefore,we further used it as a scaffold to design mini-proteins ...; 关键词：Protein design Antitumor agents In silico design Constrained peptide Epitope grafting

Anti-tumor effects of combined doxorubicin and siRNA for pulmonary delivery被引量：1: 《Chinese Chemical Letters》2017年第4期807-812,共6页Cai-Na Xu Hua-Yu Tian Yan-Bing Wang Yang Du Jie Chen Lin Lin Zhao-Pei Guo Xue-Si Chen; the National Natural Science Foundationof China(Nos.51503200,21474104,5123300451520105004 and 51390484);Jilin Province Science and Technology Development Program(No.20160204032GX);the National Program for Support of Top-notch Young Professionals for financial support; Direct administration of drugs and genes to the lungs by pulmonary delivery offers a potential effective therapy for lung cancers.In this study,combined doxorubicin（DOX） and Bcl2 siRNA was employed for cancer therap...; 关键词：Pulmonary delivery Anti-tumor effects Metastatic lung cancer Combined DOX and siRNA therapy Synergistic anti-tumor

Novel NO-releasing derivatives of betulinic acid with antitumor activity被引量：1: 《Chinese Chemical Letters》2015年第6期759-762,共4页Jin-Hong Liu Zi-Fei Zhu Jia Tang Ai-Qin Jiang Liu-Fang Hu Li Chen; financially supported by the National Natural Science Foundation of China (No.20972190);the Academic Leadership of ‘Qing Lan’ Project of Jiangsu Department of Education; Thirteen novel NO-releasing derivatives of betulinic acid （BA） bearing two types of NO-donors （nitrates and furoxans） were synthesized and evaluated for their antitumor activity. The results showed that furoxan-ba...; 关键词：Betulinic acid （BA） Derivatives NO-releasing Anti-tumor NO donors

Design of novel bis-benzimidazole derivatives as DNA minor groove binding agents被引量：2: 《Chinese Chemical Letters》2014年第4期589-592,共4页Xiu-Jun Wang Ming-Li Yang Lan-Ping Zhang Tong Yao Cheng Chen Lian-Gang Mao Yin Wang Jie Wu; supported by Wuhan City Department of Education(No.2009K106); A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound ...; 关键词：Bis-benzimidazole Anti-tumor DNA minor groove

Synthesis and anti-tumor activity evaluation of novel podophyllotoxin derivatives被引量：5: 《Chinese Chemical Letters》2013年第1期37-40,共4页Ting Ai Shao-Yu Shi Li-Ting Chen Ling Li Bo Cao Ying Gao Hong Chen Jing Zhou; In order to investigate the effects on the cytotoxicity of indole-3-oxalylamino podophyllotoxin analogs, seven novel podophyllotoxin derivatives were synthesized. The compounds were tested against Hela, K562 or K562/A...; 关键词：Podophyllotoxin C4-N-substitution INDOLE CYTOTOXICITY

Synthesis and in vitro biological evaluation of farnesylthiosalicylic acid derivatives as anti-tumor carcinoma agents被引量：1: 《Chinese Chemical Letters》2012年第10期1141-1144,共4页Yong Ling You An Xiao Guang Tong Chen Dong Geng Wang Yu Qin Li Xin Yang Wang Heng Zheng; support by the Natural Science Foundation of Jiangsu Province in China (NoBK2011389);Applied Research Projects of Nantong City(BK2012085);funded by the Priority Academic Programs Development of Jiangsu Higher Education Institutions(PAPD); Novel farnesylthiosalicylic acid （PTA） derivatives 5a-m with different substituted 1,3,4-thiadiazoles were synthesized. Compounds 5b, 5e, 5e and 5f displayed anti-tumor activities superior to FTA in most cancer cell...; 关键词：SYNTHESIS Farnesylthiosalicylic acid 1 3 4-Thiodiazole Anti-tumor agents Cytotoxic activities Cell apoptosis

Synthesis of oleanolic disaccharide derivatives: 《Chinese Chemical Letters》2012年第4期403-406,共4页Shu Chen Pei Jian Bo Wu Fan Lei Shan Qian Li Hai Yong Wu; supported by the National Natural Sciences Foundation of China(No.81072532);Scientific Research Fund of Sichuan Provincial Education Department(No.11205023); Oleanolic acid 1 exists widely in food,medicinal herbs and other plants and possesses many attractive biological activities. Recently,some oleanolic derivatives were reported to have interesting anti-tumor activities....; 关键词：Oleanolic acid Rhamnopyranosyl Arabinopyranosyl ANTI-TUMOR Association principle

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

ANTI-TUMOR

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

ANTI-TUMOR

检索结果分析

下载全文

用户登录

高级检索检索式检索