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Alzheimer's disease treatment landscape:current therapies and emerging mechanism-targeted approaches
《Neural Regeneration Research》2025年第12期3531-3532,共2页Eleen Yang Khaled S.Abd-Elrahman 
supported by a New Investigator grant from the Alzheimer’s Society of Canada;research grant from Djavad Mowafaghian Centre for Brain Health to KSAE。
Alzheimer's disease (AD) is an age-related neurodegenerative disease that involves a progressive decline in memory,thinking,a nd learning.AD has been studied rigorously for more than 50 years yet there is a marked lac...
关键词:ALZHEIMER diagnosis LANDSCAPE 
Induced pluripotent stem cell-related approaches to generate dopaminergic neurons for Parkinson's disease
《Neural Regeneration Research》2025年第11期3193-3206,共14页Ling-Xiao Yi Hui Ren Woon Genevieve Saw Li Zeng Eng King Tan Zhi Dong Zhou 
supported by Singapore National Medical Research Council(NMRC)grants,including CS-IRG,HLCA2022(to ZDZ),STaR,OF LCG 000207(to EKT);a Clinical Translational Research Programme in Parkinson's Disease;Duke-Duke-NUS collaboration pilot grant(to ZDZ)。
The progressive loss of dopaminergic neurons in affected patient brains is one of the pathological features of Parkinson's disease,the second most common human neurodegenerative disease.Although the detailed pathogene...
关键词:dopaminergic neurons induced pluripotent stem cells Parkinson's disease stem cell approaches 
Computational approaches for circRNA-disease association prediction:a review
《Frontiers of Computer Science》2025年第4期99-113,共15页Mengting NIU Yaojia CHEN Chunyu WANG Quan ZOU Lei XU 
supported by the National Natural Science Foundation of China(Grant Nos.62231013,62201129,62303328,62302341,62271329,62372332);the National Key R&D Program of China(2022ZD0117700);the National funded postdoctoral researcher program of China(GZC20230382);the Shenzhen Polytechnic University Research Fund(6024310027K,6022310036K,6023310037K);the Key Field of Department of Education of Guangdong Province(2022ZDZX2082);the Special Science Foundation of Quzhou(2023D036).
Circular RNA(circRNA)is a covalently closed RNA molecule formed by back splicing.The role of circRNAs in posttranscriptional gene regulation provides new insights into several types of cancer and neurological diseases...
关键词:circular RNA disease association prediction machine learning data mining deep learning 
Microneedle-Based Approaches for Skin Disease Treatment
《Nano-Micro Letters》2025年第6期143-180,共38页Yanhua Han Xiaoyu Qin Weisen Lin Chen Wang Xuanying Yin Jiaxin Wu Yang Chen Xiaojia Chen Tongkai Chen 
supported through grants from the Key Fields of Biomedicine and Health Foundation of Colleges and Universities in Guangdong Province(2022ZDZX2017);the National Natural Science Foundation of China(82104354);the Guangdong Basic and Applied Basic Research Foundation(2022A1515012154);the funding grants from University of Macao and the University of Macao Development Foundation(MYRG2023-GRG00184-ICMS-UMDF and MYRG2024-GRG00271-ICMS-UMDF).
The use of microneedles(MNs)has been established as an effective transdermal drug delivery strategy that has been extensively deployed for treating various diseases,including skin diseases.MNs can surpass the constrai...
关键词:MICRONEEDLES Androgenetic alopecia PSORIASIS Atopic dermatitis Hypertrophic scars MELANOMA 
Application of Multi-Criteria Decision and Simulation Approaches to Selection of Additive Manufacturing Technology for Aerospace Application
《Computers, Materials & Continua》2025年第5期1623-1648,共26页Ilesanmi Afolabi Daniyan Rumbidzai Muvunzi Festus Fameso Julius Ndambuki Williams Kupolati Jacques Snyman 
This study evaluates the Fuzzy Analytical Hierarchy Process(FAHP)as a multi-criteria decision(MCD)support tool for selecting appropriate additive manufacturing(AM)techniques that align with cleaner production and envi...
关键词:Additive manufacturing(AM) cleaner production computer-aided modelling and simulation environmental responsibility MCD SUSTAINABILITY 
Different Approaches to The Unhoused
《Beijing Review》2025年第14期25-25,共1页Zhong Mei 
While the United States may currently be divided on how best to address homelessness,both sides of the debate agree the nation is in the midst of a long-term crisis.In 2024,the number of people experiencing homelessne...
关键词:united states experiencing HIGH PEOPLE NUMBER APPROACHES HOMELESSNESS CRISIS 
Optimization-Based Approaches to Uncertainty Analysis of Structures Using Non-Probabilistic Modeling:A Review
《Computer Modeling in Engineering & Sciences》2025年第4期115-152,共38页Yoshihiro Kanno Izuru Takewaki 
partially supported by JSPS KAKENHI JP24K07747.
Response analysis of structures involving non-probabilistic uncertain parameters can be closely related to optimization.This paper provides a review on optimization-based methods for uncertainty analysis,with focusing...
关键词:UNCERTAINTY non-probabilisticmodeling optimization methods bound for structural response ROBUSTNESS 
Ensemble Deep Learning Approaches in Health Care:A Review
《Computers, Materials & Continua》2025年第3期3741-3771,共31页Aziz Alotaibi 
funded by Taif University,Saudi Arabia,project No.(TU-DSPP-2024-263).
Deep learning algorithms have been rapidly incorporated into many different applications due to the increase in computational power and the availability of massive amounts of data.Recently,both deep learning and ensem...
关键词:Deep learning ensemble learning deep ensemble learning deep learning approaches for health care health care 
Wide Bandgap Semiconductors for Ultraviolet Photodetectors:Approaches,Applications,and Prospects
《Research》2025年第1期257-279,共23页Fa Cao Ying Liu Mei Liu Zeyao Han Xiaobao Xu Quli Fan Bin Sun 
supported by the Natural Science Research Start-up Foundation of Recruiting Talents and the Project of State Key Laboratory of Organic Electronics and Information Displays of Nanjing University of Posts and Telecommunication(nos.NY223177,NY221005,NY223179,and GZR2024010026);National Natural Science Foundation of China(62374091);the Special Professor Fund of Jiangsu Province(RK030STP21007).
Ultraviolet(UV)light,invisible to the human eye,possesses both benefits and risks.To harness its potential,UV photodetectors(PDs)have been engineered.These devices can convert UV photons into detectable signals,such a...
关键词:environmental monitoringhealthcareand wide bandgap semiconductors UV light opto electronic properties bandgap semiconductorswith electrical impulses ultraviolet photodetectors 
Harnessing Trend Theory to Enhance Distributed Proximal Point Algorithm Approaches for Multi-Area Economic Dispatch Optimization
《Computers, Materials & Continua》2025年第3期4503-4533,共31页Yaming Ren Xing Deng 
funded by Guangxi Science and Technology Base and Talent Special Project,grant number GuiKeAD20159077;Foundation of Guilin University of Technology,grant number GLUTQD2018001.
The exponential growth in the scale of power systems has led to a significant increase in the complexity of dispatch problem resolution,particularly within multi-area interconnected power grids.This complexity necessi...
关键词:Multi-area economic dispatch problem proximal point algorithm trend theory 
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