CLC-3 chloride(Cl-)channel,a member of an extended family of voltagegated CLC chloride channels and transporters,are ubiquitously expressed throughout the nervous system,including in the cerebrovascular smooth muscle ...
Background:Currently,diagnosis of major depressive disorder(MDD)still relies on symptoms.There are some problems for the diagnostic criteria,like low diagnostic consistency and difficulty in differentiation of MDD and...
Nicotinic acetylcholine receptors(nAChRs)are ligand-gated ion channels that are activated by neurotransmitter acetylcholine for signaling,and they also respond to drugs including the nicotinic receptor agonist nicotin...
This work was supported by grants from National Natural Science Foundation of China(31730040 and 81070884).
More than 20%of adults worldwide suffer from different types of chronic pain,which are frequently associated with several comorbidities and adverse impact on patient quality of life.Although several approved analgesic...