Supported by the Natural Science Foundation of China(No.30572438);the Beijing Science Nuture Foundation(No.7132189);Science Foundation of Peking Union Medical College Hospital(No.2013-098);Youth Foundation of Peking Union Medical College Hospital
Objective: To observe the deregulation of autophagy in diabetic peripheral neuropathy (DPN) and investigate whether Jinmaitong (筋脉通, JMT) alleviates DPN by inducing autophagy. Methods: DPN models were establi...
Autophagy is a highly evolutionarily conserved pathway that depends on lysosome to degrade misfolded proteins and damaged organelles. Besides canonical autophagy, studies have shown some chemicals could bypass sever...
This research was supported by grants from the National Natural Science Foundation of China (Grant Nos. 81273231,81172799 to Z. C. and 81102478, 81471947 to Y. X.).
Autophagy plays important roles in modulating viral replication and antiviral immune response. Coronavirus infection is associated with the autophagic process, however, little is known about the mechanisms of autophag...
Autophagy is an intracellular degradation process to clear up aggregated proteins or aged and damaged organelles. The Beclinl-Vps34-Atg14L complex is essential for autophagosome formation. However, how the complex for...