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作品数:1050被引量:2083H指数:18
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相关领域:自动化与计算机技术医药卫生更多>>
相关作者:凌凤香范峰赵震肖丰收段爱军更多>>
相关机构:中国科学院北京大学山东大学中国石油化工股份有限公司更多>>
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Modeling the modulation of beta oscillations in the basal ganglia by dual-target optogenetic stimulation被引量:1
《Fundamental Research》2025年第1期82-92,共11页Xiaomin Wang Ying Yu Qingyun Wang 
supported by the National Natural Science Foundation of China(12202027,11932003 and 12332004);the Academic Excellence Foundation of BUAA for PhD Students.
Optogenetic techniques provide precise control over the activity of specific neurons within the nucleus,offering more accurate regulatory effects compared to deep brain stimulation.The heterogeneity of the globus pall...
关键词:Dual-target optogenetic stimulation Beta oscillation Heterogeneous globus pallidus externa Parkinson's disease Computational model 
Beta受体阻滞剂减少危重症患者的住院病死率
《岭南急诊医学杂志》2025年第1期41-45,共5页袁晓思 李泽雄 吴库生 
目的:本研究旨在探讨住院期间使用Beta受体阻滞剂对危重症患者住院病死率、总住院时长及ICU住院时长的影响。方法:检索MIMIC III数据库,识别大于等于18岁的危重症患者。根据住院期间是否使用Beta受体阻滞剂,分为非BBs组(Beta-blockers)...
关键词:Beta受体阻滞剂 危重症患者 住院病死率 倾向性评分匹配 
麻杏石甘汤干预流感病毒肺炎小鼠前后肺部菌群变化的研究
《辽宁中医药大学学报》2025年第1期7-12,共6页杨钦惠 郝欧美 张柯欣 李莹 
国家自然科学基金面上项目(82274580);沈阳市科技计划项目(21-174-9-07)。
目的探究小鼠感染流感病毒肺炎前后肺部菌群的变化及经麻杏石甘汤干预后对小鼠肺部菌群的影响。方法采取滴鼻造模的方法建立流感病毒肺炎小鼠模型,经麻杏石甘汤或生理盐水干预不同时间后,提取小鼠肺组织进行16S rDNA测序数据处理及个性...
关键词:麻杏石甘汤 流感病毒 肺部菌群 Alpha多样性分析 Beta多样性分析 
Single-cell analysis of tumor microenvironment and cell adhesion reveals that interleukin-1 beta promotes cancer cell proliferation in breast cancer被引量:1
《Animal Models and Experimental Medicine》2024年第5期617-625,共9页Wenyan Wang Gehong Dong Ziguo Yang Shaoxiang Li Jia Li Lin Wang Qiang Zhu Yuchen Wang 
funded by Young Elite Scientists Sponsorship Program by Beijing Association for science and technology(Grant No.BYESS2023226)。
Background: Triple-negative breast cancer(TNBC), which is so called because of the lack of estrogen receptors(ER), progesterone receptors(PR), and human epidermal growth factor receptor 2(HER2) receptors on the cancer...
关键词:biomaterial breast cancer IL1B plasma cells scRNA-seq 
Conservative Management of Unruptured Ectopic Pregnancy—A Retrospective Study
《Surgical Science》2024年第10期536-546,共11页Yazhini Selvaraj 
An ectopic pregnancy (EP) is defined as any pregnancy that occurs outside the uterine cavity. The most common site of ectopic pregnancy is the fallopian tube. The goal of this retrospective study is to address medical...
关键词:Ectopic Pregnancy (EP) Beta-Human Chorionic Gonadotrophin (β-HCG) Medical Management Methotrexate (MTX) SALPINGOSTOMY 
Heme oxygenase 1-mediated ferroptosis in Kupffer cells initiates liver injury during heat stroke
《Acta Pharmaceutica Sinica B》2024年第9期3983-4000,共18页Ru Li Riqing Wei Chenxin Liu Keying Zhang Sixiao He Zhifeng Liu Junhao Huang Youyong Tang Qiyuan An Ligen Lin Lishe Gan Liying Zhao Xiaoming Zou Fudi Wang Yuan Ping Qiang Ma 
the following funding sources:the National Natural Science Foundation of China(82072100 to Qiang Ma and 82172814 to Liying Zhao);the Natural Science Foundation of Shenzhen(JCYJ20210324120212033,China);Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy,School of Laboratory Medicine and Biotechnology,Southern Medical University(2022B1212010009,China).
With the escalating prevalence of global heat waves,heat stroke has become a prominent health concern,leading to substantial liver damage.Unlike other forms of liver injury,heat strokeinduced damage is characterized b...
关键词:Heat stroke Liver injury Kupffer cells Ferroptosis Heme oxygenase 1 Phosphatidylinositol 4-kinase beta NLRP3 Early growth response factor 1 
Integrative analyses identified gap junction beta‐2 as a prognostic biomarker and therapeutic target for breast cancer
《Cancer Innovation》2024年第4期43-56,共14页Di Zhang Lixi Li Fei Ma 
Background:Increasing evidence has shown that connexins are involved in the regulation of tumor development,immune escape,and drug resistance.This study investigated the gene expression patterns,prognostic values,and ...
关键词:breast cancer CONNEXIN gap junction beta‐2 phosphoinositide 3‐kinase‐Akt‐mTOR pathway prognosis 
糖尿病病程联合24 h-UPr和β-CTX对2型糖尿病视网膜病变的诊断价值
《浙江医学》2024年第11期1130-1134,1141,共6页叶立芳 祝聪 杨训俊 李姗姗 
目的通过研究2型糖尿病(T2DM)患者合并糖尿病视网膜病变(DR)的相关因素,探寻可能有价值的预测指标。方法回顾性分析2020年1月至2021年12月温州医科大学附属第二医院内分泌科收治的356例T2DM患者临床资料,根据眼底彩照和(或)眼底造影结果...
关键词:2型糖尿病 糖尿病视网膜病变 24小时尿蛋白 糖尿病病程 Ⅰ型胶原交联C-末端Beta特殊序列 
HBB contributes to individualized aconitine-induced cardiotoxicity in mice via interfering with ABHD5/AMPK/HDAC4 axis被引量:1
《Acta Pharmacologica Sinica》2024年第6期1224-1236,共13页Ya-juan Guo Jing-jing Yao Zhen-zhen Guo Ming Ding Kun-lin Zhang Qing-hong Shen Yu Li Shao-fang Yu Ting Wan Fu-ping Xu Ying Wang Xiao-xiao Qi Jin-jun Wu Jian-xin Chen Zhong-qiu Liu Lin-lin Lu 
supported by National Natural Science Foundation of China(82022074 and 82274196);the 2020 Guangdong Provincial Science and Technology Innovation Strategy Special Fund(Guangdong-Hong Kong-Macao Joint Lab,2020B1212030006);Key-Area Research and Development Program of Guangdong Province(2020B1111100004).
The root of Aconitum carmichaelii Debx.(Fuzi)is an herbal medicine used in China that exerts significant efficacy in rescuing patients from severe diseases.A key toxic compound in Fuzi,aconitine(AC),could trigger unpr...
关键词:ACONITINE CARDIOTOXICITY individual differences hemoglobin subunit beta nitrogen monoxide ABHD5/AMPK/HDAC4 axis 
新型冠状病毒Beta变异株感染C57BL/6小鼠肺组织转录组分析及趋化因子实验验证
《病毒学报》2024年第2期255-265,共11页张高倩 吴长城 黄保英 李涵 霍恕婷 叶飞 赵莉 阿茹罕 张钟贤 沈晓玲 谭文杰 
国家重点研发计划(项目号:2022YFC2304101),题目:新冠与流感病毒抗原变异监测及通用型多肽疫苗的临床前评价;国家重点研发计划(项目号:2022YFC2303401),题目:潜在高危新病毒风险识别的新技术体系研究;国家重点研发计划(项目号:2021YFA1201003),题目:抗病毒纳米药物的体内外功能评价;国家重点研发计划(项目号:2023YFC3041500),题目:奥密克戎变异规律分析与防控研究。
研究旨在通过从转录组水平分析新冠病毒Beta变异株感染C57BL/6小鼠肺部的基因表达变化,以揭示引发轻症肺部损伤的关键宿主因子。首先构建Beta变异株感染C57BL/6小鼠模型,并对感染和未感染第3天(3d)小鼠的肺组织进行病原检测、病理分析...
关键词:新型冠状病毒Beta变异株 肺部损伤 天然免疫 炎症因子 转录组 
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