AIM: To investigated the interaction between toll-like receptor 4 (TLR4)-activated hepatoma cells and macrophages in the induction of tumor-immune suppression mediated by CD4+CD25high family of transcription factor P3...
Background Astragalus polysaccharides (APS), the main active extract from Astragalus membranaceus (a traditional Chinese medicinal herb), is associated with a variety of immunomodulatory activities. The purpose of...
Supported by the Natural Science Foundation of Shanghai,China(04ZR14109)
Objective To evaluate the prevalence of CD4 ^+ CD25^high regulatory T cells ( Treg cells) in the peripheral blood mononuclear cells (PBMC) and tumor-infiltrating lymphocytes (TIL) of patients with non-small cel...
ZHANG Qian and QIAN Fen-hong equally contributed to this work. This study was supported by the grants from the National Natural Science Foundation of China (No. 30400191 and 30570797), Key Subject of Project "135" of Jiangsu Province (No. 20013102) and Summit Project of Jiangsu Human Resources (No. 06B035).
Background CD4^+CD25^+ regulatory T cells (Tregs) mediate immune suppression through cell-cell contact with surface molecules, particularly cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), glucocorticoid-in...