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CHAIN: 作品数：1276被引量：1740H指数：17; 导出分析报告; 相关领域：理学医药卫生更多>>; 相关作者：韩俊林李晓松丛方媛王彩玲师义民更多>>; 相关机构：四川大学中国科学技术大学武汉大学浙江大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划国家高技术研究发展计划国家社会科学基金更多>>

A Highly Sensitive Electrochemical Aptasensor for Kanamycin:Leveraging RecJf Exonuclease-Assisted Target Recycling and Hybridization Chain Reaction Signal Amplification: 《Journal of Analysis and Testing》2025年第1期96-108,共13页Qi Xiao Dongyou Zhang Mingli Yang Shuai Liu Yi Fang Shan Huang; financially supported by Central Government Guided Local Science and Technology Development Fund Project(guikeZY22096017);Natural Science Foundation of Guangxi Province(2024GXNSFDA010036);National Natural Science Foundation of China(22164014,U23A2089)。; A highly sensitive electrochemical aptasensor was developed for the detection of kanamycin,employing a DNA signal amplification strategy that combines RecJf exonuclease-assisted target recycling with a hybridization c...; 关键词：KANAMYCIN Target recycling Hybridization chain reaction Signal amplification Long dsDNA nanostructures

Size-selective hybridization chain reaction for accurate signal amplification in living cancer cells: 《Science China Chemistry》2024年第12期4259-4266,共8页Ting Chen Xiaojiao Wang Rongrong Gao Meihe Yuan Mei Chen Xiao-Bing Zhang Guoliang Ke; supported by the National Natural Science Foundation of China(22122403,22274042,22234003);the Natural Science Foundation of Hunan Province(2021JJ10012)。; Accurate signal amplification in living cells is highly important in biomedical research and medical diagnostics.Benefiting from its enzyme-free,efficient isothermal signal amplification ability,hybridization chain re...; 关键词：hybridization chain reaction microRNA DNA nanotechnology

A Bifunctional-Blocker-Aided Hybridization Chain Reaction Lighting-Up Self-calibrating Nanocluster Fluorescence for Reliable Nucleic Acid Detection: 《Journal of Analysis and Testing》2024年第2期160-169,共10页Dan Zhang Guobao Zhou Hongyan Yang Yi Wang Lijun Shen Yuxuan Qiu Lei Li Longhua Guo; supported by the National Natural Science Foundation of China(22304062);the Zhejiang Provincial Natural Science Foundation of China(LTGY24B050002);the Program for Science and Technology of Jiaxing(2023AY40028);the Baiqing Foundation of Jiaxing University(CD70621010)Springer Nature or its licensor(e.g.a society or other partner)holds exclusive rights to this article under a publishing agreement with the author(s)or other rightsholder(s);author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law。; In this work,we proposed a ratiometric silver nanoclusters(AgNCs)fluorescent assay by designing a bifunctional-blockeraided hybridization chain reaction(HCR).Hairpin probe 1(HP1)containing two special DNA fragments(5...; 关键词：Ratiometric fluorescence Hybridization chain reaction Silver nanocluster Biosensor Bifunctional blocker

Hybridization chain reaction-based DNA nanomaterials for biosensing,bioimaging and therapeutics被引量：2: 《Chinese Chemical Letters》2024年第2期223-231,共9页Zhaoyue Lv Mengxue Huang Peiran Li Mengdi Xu Chi Yao Dayong Yang; supported in part by National Natural Science Foundation of China(Nos.22225505,22174097).; DNA nanomaterials hold great promise in biomedical fields due to its excellent sequence programmability,molecular recognition ability and biocompatibility.Hybridization chain reaction(HCR)is a simple and efficient iso...; 关键词：DNA nanotechnology Hybridization chain reaction DNA nanomaterials BIOSENSING BIOIMAGING Therapeutics

Extracellular ATP-activated hybridization chain reaction for accurate and sensitive detection of cancer cells: 《Chinese Chemical Letters》2023年第12期495-498,共4页Lie Li Suping Li Jie Wang Xiaohong Wen Mei Yang Haiyan Chen Qiuping Guo Kemin Wang; supported by the Natural Science Foundation of China(Nos.21877030,21735002 and 21778016).; Accurate and sensitive detection of caner cells is of significant importance for early diagnosis and treat-ment of cancer.Here,we developed an extracellular ATP-dctivated hybridization chain reaction(HCR)amplification...; 关键词：Cancer cells ATP APTAMER Hybridization chain reaction Fluorescence

Electrochemical analysis of microRNAs with hybridization chain reaction-based triple signal amplification被引量：1: 《Chinese Chemical Letters》2023年第7期210-213,共4页Jianfeng Ma Lingbo Gong Yingying Cen Lin Feng Yan Su Xingfen Liu Jie Chao Ying Wan Shao Su Lianhui Wang; supported by the National Key Research and Development Program of China (No. 2017YFA0205302);the Natural Science Foundation of Jiangsu Province-Major Project (No. BK20212012);the National Natural Science Foundation of China (No. 21874071);the “Six Talents Peak” Foundation of Jiangsu Province (No. SWYY-046);the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD, No. YX030003)。; Selective and sensitive detection of trace microRNA is important for early diagnosis of diseases due to its expression level related to diseases.Herein,a triple signal amplification strategy is developed for trace mic...; 关键词：Electrochemical BIOSENSOR MICRORNAS Hybridization chain reaction Target-triggered cyclic strand displacement REACTION Triple signal amplification

An Endogenous miRNA-Initiated Hybridization Chain Reaction and Subsequent DNAzyme Activation for Cellular Theranostics: 《CCS Chemistry》2022年第11期3505-3515,共11页Ke Quan Jiaoli Wang Jing Li Kemin Wang Jin Huang; This work was supported by the National Natural Science Foundation of China(nos.21735002 and 21874036);the Opening Foundation of the State Key Laboratory of Chemo/Biosensing and Chemometrics,Hunan University(no.2019013);the Changsha Municipal Natural Science Foundation(no.kq2007021);the Natural Science Foundation for Distinguished Young Scholars of Hunan Province(no.2021JJ10011).; DNAzyme has emerged as a promising gene silencer for therapeutic applications.However,DNAzymebased gene therapy against tumors is still challenged by undesired cytotoxicity in normal cells.Herein,we explored the poten...; 关键词：DNAzyme gene silencing hybridization chain reaction RNA cellular theranostic

Chemical Industry:Chain Reaction: 《China Weekly》2022年第5期32-34,共3页Zhou Qunfeng; Experts are concerned that relocation of industrial chemical plants from coastal to inland regions might bring about increased risks caused by lax regulations,Three years after a deadly blast at a chemical plant in Xi...; 关键词：INLAND COASTAL concerned

Optimizing the hybridization chain reaction-fluorescence in situ hybridization(HCR-FISH)protocol for detection of microbes in sediments: 《Marine Life Science & Technology》2021年第4期529-541,共13页Zeyu Jia Yijing Dong Heng Xu Fengping Wang; We thank for the funding:National Key R&D Program of China(grant numbers 2018 YFC0310800,2018YFC0310803);COMRA Project DY135-B2-12;the National Natural Science Foundation of China(grant numbers 41525011,91751205,11774225);the Recruitment Program of Global Experts(Program for Young Professionals),and the Natural Science Foundation of Shanghai(grant no.18ZR1419800);This is also a contribution to the Center for Ocean Mega-Science,Chinese Academy of Sciences,the Senior User Project of RV KEXUE(KEXUE2019GZ06);the International Center for Deep-Life Investigation(IC-DLI).We thank Gunter Wegener for providing the ANME enrichment sample.; Fluorescence in situ hybridization(FISH)is a canonical tool commonly used in environmental microbiology research to visualize targeted cells.However,the problems of low signal intensity and false-positive signals impe...; 关键词：Fluorescence in situ hybridization Hybridization chain reaction HCR-FISH Microbial detection Sediment

Laboratory diagnosis of schistosomiasis mansoni: Current status and future trends: 《Asian Pacific Journal of Tropical Medicine》2019年第6期243-249,共7页Amira Taman Samar N.El-Beshbishi; Schistosomiasis is a neglected tropical disease that affects about 290 million patients worldwide. Children aged between 5 and 14 years represent 45.8% of the affected patients, in addition, schistosomiasis has been r...; 关键词：SCHISTOSOMA MANSONI ELISA miRNA TEGUMENT POLYMERASE CHAIN REACTION

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