云南高校图书馆联盟文献共享服务平台- CLPP

CLPP: 作品数：38被引量：198H指数：4; 导出分析报告; 相关领域：医药卫生农业科学更多>>; 相关作者：韩育植于丹妮张加勤尹一兵李岱容更多>>; 相关机构：重庆医科大学中国科学院天津医科大学南京农业大学更多>>; 相关期刊：《Journal of Ocean University of China》《Emerging Contaminants》《天津医药》《现代生物医学进展》更多>>; 相关基金：国家自然科学基金江苏高校优势学科建设工程资助项目福建省自然科学基金国家科技重大专项更多>>

Corrigendum to:HSPA8-mediated stability of the CLPP protein regulates mitochondrial autophagy in cisplatin-resistant ovarian cancer cells: 《Acta Biochimica et Biophysica Sinica》2025年第2期326-326,共1页Xinxin Kou Xiaoxia Yang Zheng Zhao Lei Li; Acta Biochim Biophys Sin 2024,56(3):356–365 https://doi.org/10.3724/abbs.2023246 In the originally published version of this article,the Author′s affiliation was set incorrectly.This has now been corrected,and the a...; 关键词：Cancer COR CISPLATIN

Foliar spraying of chlorpyrifos induces morphometric changes in Glycine max(L.)and shifts native soil microbiome: 《Emerging Contaminants》2024年第3期86-102,共17页Aman Raj Muneer Ahmad Malla Ashwani Kumar Pramod Kumar Khare Sheena Kumari; support obtained through the project grant of(CRG/2021/003696);New Delhi,Govt of India.SK&MM would like to acknowledge the National Research Foundation of South Africa(UID number 129358)for financial support.; Pesticide usage alters plant growth,and development and disturbs native soil microbiome.The present study was carried out to evaluate the effect of Chlorpyrifos(CP-20%EC)on the growth and development of soybean(Glycin...; 关键词：CHLORPYRIFOS Glycine max Proline Metabolic activity CLPP METAGENOMICS Bacterial microbiome

线粒体ClpP激动剂抗肿瘤的研究进展: 《药物生物技术》2024年第4期437-443,共7页丁豪刘笑妍肖易倍; 国家重点研究计划“基于成药性特征的微生物天然产物合成生物学创制”(No.2018YFA0902000)。; 线粒体是执行和协调细胞内多种代谢和生命活动的重要细胞器。线粒体功能障碍严重影响细胞的健康,导致神经退行性疾病、心血管疾病以及肿瘤等的发生。线粒体内受损的蛋白或者错误折叠的蛋白堆积会引发整合应激反应和未折叠蛋白反应,线粒...; 关键词：ClpP蛋白酶线粒体质控激动剂肿瘤治疗氧化磷酸化未折叠蛋白反应

酪蛋白水解酶ClpP的结构研究与功能干预: 《中国科学：化学》2024年第5期703-715,共13页王蓬宇张涛杨财广; 国家自然科学基金重点项目(编号:22037007);国家自然基金青年基金项目(编号:22107109);中国科学院青年创新促进会(编号:2023297)资助。; 酪蛋白水解酶ClpP是一种高度保守的丝氨酸蛋白水解酶,通常与AAA+超家族ATP酶的伴侣蛋白形成复合物调控细胞内蛋白质稳态.化学干预ClpP蛋白水解酶的生物学功能,尤其是小分子激动剂的开发已被证明是治疗多种疾病的有效策略.近年来,本课题...; 关键词：酪蛋白水解酶ClpP 分子识别化学干预抗菌抗肿瘤

HSPA8-mediated stability of the CLPP protein regulates mitochondrial autophagy in cisplatin-resistant ovarian cancer cells被引量：1: 《Acta Biochimica et Biophysica Sinica》2024年第3期356-365,共10页Xinxin Kou Xiaoxia Yang Zheng Zhao Lei Li; This work was supported by the grant from the construction Joint Project of Henan Province Medical Science and Technology Research Plan in 2022(No.LHGJ20220200).; Currently,platinum agents remain the mainstay of chemotherapy for ovarian cancer(OC).However,cisplatin(DDP)resistance is a major reason for chemotherapy failure.Thus,it is extremely important to elucidate the mechanis...; 关键词：cisplatin resistance ovarian cancer caseinolytic protease P heat shock protein family A member 8 MITOPHAGY

细菌ClpP蛋白酶功能及其抗菌药物靶点的研究进展被引量：1: 《中国抗生素杂志》2022年第1期15-21,共7页颜骊颖张亚培董世雷; 国家自然科学基金(No.81801978);浙江省医药卫生科技计划项目(No.2018KY201);浙江省公益技术研究计划项目(No.LGF21H190001)。; ClpP(Casein lytic proteinase P)是一种广泛存在于真核细胞和原核生物中的丝氨酸蛋白酶,可与多种类型AAA+(ATPase associated with various cellular activity)超家族ATP酶组成多种ClpP蛋白酶复合物,其主要功能是清除或降解细菌胞内合...; 关键词：酪蛋白水解蛋白酶P(ClpP) 蛋白降解致病机制酰基缩肽(ADEPs) 药物开发

Metabolic diversity and seasonal variation of soil microbial communities in natural forested wetlands: 《Journal of Forestry Research》2021年第6期2619-2631,共13页Di Wu Qi Chi Xin Sui Mengmeng Zhang Hongbai Jia Guangyu Sun; The work was supported by the National Natural Science Foundation of China(No.31500508);the Fundamental Research Funds for the Central Universities(No.2572020BD02);Natural Science Foundation of Heilongjiang Province(No.LH2020C041).; This study explores the effects of vegetation and season on soil microorganisms and enzymatic activity of different wetlands in a temperate climate.Microbial carbon metabolism diversity was assessed using community-le...; 关键词：Forested wetlands Community-level physiological profiles(CLPP) Carbon metabolism diversity Soil enzymatic activity SEASONALITY

Design,Synthesis and Biological Evaluation of Bengamide Analogues as ClpP Activators被引量：2: 《Chinese Journal of Chemistry》2020年第10期1111-1115,共5页Xue-Qing Kong Bing-Yan Wei Chen-Xi Yu Xiang Na Guan Wei-Ping Ma Gang Liu Cai-Guang Yang Fa-Jun Nan; We would like to thank Hanne Ingmer for providing the strains of 8325-4,ΔclpP and ΔcpP::clpP.This work was supported by Science and Technology Commission Shanghai Municipality(16ZR1407000 and 17XD1404400);the National Natural Sci-ence Foundation of China(81861138046).; Summary of main observation and conclusion To combat multidrug-resistant Gram-positive bacteria,new antimicrobials particularly those with novel mechanism of action are badly needed.Different with conventional antibio...; 关键词：ANALOGUES ACTIVATION STARTING

Responses of soil microbial communities and functions associated with organic carbon mineralization to nitrogen addition in a Tibetan grassland被引量：5: 《Pedosphere》2020年第2期214-225,共12页Ruyi LUO Jiafa LUO Jianling FAN Deyan LIU Jin-Sheng HE Nazia PERVEEN Weixin DING; supported by the National Program on Key Basic Research Project(No.2014CB954002);the National Natural Science Foundation of China(No.31561143011)。; Alpine grasslands with a high soil organic carbon(SOC)storage on the Tibetan Plateau are experiencing rapid climate warming and anthropogenic nitrogen(N)deposition;this is expected to substantially increase the soil N...; 关键词：ALPINE GRASSLAND C cycling C TURNOVER COMMUNITY level physiological profiles(CLPP) enzyme activity MICROBIAL COMMUNITY composition MICROBIAL function N input

牛种布鲁氏菌clpP基因缺失株的毒力和免疫保护力评价被引量：3: 《中国动物检疫》2019年第11期59-64,共6页彭小薇吴方达刘郁夫董浩孙永健毕一鸣张存瑞刘林青韩焘; 国家自然科学基金项目(31602017); 为研究布鲁氏菌clpP基因与细菌毒力的关系,采用同源重组的方法,构建牛种布鲁氏菌clpP基因缺失株,用巨噬细胞RAW264.7感染模型和小鼠感染模型评价clpP基因缺失株的毒力,同时测定该缺失株免疫小鼠后产生的免疫保护力。研究发现:牛种布鲁氏...; 关键词：布鲁氏菌疫苗 clpP基因毒力基因缺失株免疫保护

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