COLON_CANCER

作品数：635被引量：2234H指数：19
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相关作者：马蓓张尚武林雪江涛魏霞更多>>
相关机构：复旦大学附属肿瘤医院第二军医大学中国科学院大学华北理工大学更多>>
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相关基金：国家自然科学基金国家高技术研究发展计划广东省自然科学基金中国博士后科学基金更多>>
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Death domain-associated protein(Daxx)impairs colon cancer chemotherapy by inhibiting the cGAS-STING pathway
《Oncology Research》2025年第5期1149-1159,共11页XI ZHU KAI HUANG XIAOMING KAO ZHAOHUI TANG WENJIE GUO TIANCONG WU QIURONG LI 
supported by the National Natural Science Foundation of China(82202956)。
Background:Colorectal cancer(CRC)holds the third position in global cancer prevalence mortality.Although chemotherapy is a conventional treatment,recent investigations have shed light on the therapeutic potential of t...
关键词：Death domain-associated protein(Daxx) Stimulator of the interferon gene(STING) Colorectal cancer(CRC) CHEMOTHERAPY 
F-box protein 22: A prognostic biomarker for colon cancer associated with immune infiltration and chemotherapy resistance
《World Journal of Gastrointestinal Oncology》2025年第4期365-383,共19页Xiao-Fei Lu Hong-Wei Zhang Xiao Chang Yong-Ze Guo 
The study was reviewed and approved by institutional ethics board of Affiliated Hospital of Hebei Engineering University(No.:2024[K]005-01).
BACKGROUND Colon cancer represents a significant malignant neoplasm within the digestive system,characterized by a high incidence rate and substantial disease burden.The F-box protein 22(FBXO22)plays a role in forming...
关键词：Colorectal cancer F-box protein 22 BIOMARKER PROGNOSIS Tumor immunology 
Tetramethylpyrazine induces reactive oxygen species-based mitochondria-mediated apoptosis in colon cancer cells
《World Journal of Gastrointestinal Oncology》2025年第4期442-450,共9页Yan-Xu Hou Wei Ren Qing-Qiang He Li-Yan Huang Tian-Hua Gao Hua Li 
BACKGROUND Colon cancer is one of the most common malignancies worldwide,and chemo-therapy is a widely used strategy in colon cancer clinical therapy.Chemotherapy resistance is the main cause of recurrence and progres...
关键词：TETRAMETHYLPYRAZINE Colon cancer Reactive oxygen species APOPTOSIS Cell proliferation 
Chronic myelogenous leukemia secondary to colon cancer: A case report
《World Journal of Gastrointestinal Oncology》2025年第4期495-502,共8页Xiao-Lan Li Min Li Hua Yang Juan Tian Zi-Wei Shi Ling-Zhi Wang Kui Song 
Supported by the Innovation Platform and talent program of Hunan Province,No.2021SK4050;the Natural Science Foundation of Hunan Province,No.2023JJ30608 and No.2023JJ30609.
BACKGROUND Colon cancer is a common malignancy of the digestive tract.An estimated 1148515 new cases of colon cancer were reported in 2020 worldwide.Chronic myeloid leukemia(CML)is a malignant tumor formed by the clon...
关键词：Chronic myelogenous leukemia Colon cancer THERAPY-RELATED CHEMOTHERAPY Case report 
Pan-immune-inflammation in colon cancer:A prognostic biomarker and the role of tumor location in personalized care
《World Journal of Gastrointestinal Surgery》2025年第4期1-6,共6页Gaya Spolverato Giulia Capelli Floriane Noel Michele Steindler Andrew Alexander Gumbs 
Despite advances in surgery,chemotherapy,and radiotherapy,the treatment of colorectal cancer(CRC)requires more personalized approaches based on tumor biology and molecular profiling.While some relevant mutations have ...
关键词：Colorectal cancer Inflammatory biomarkers Tumor location Targeted therapy 
Identification of hypermethylated CpG sites mapped to LIFR as specific diagnostic biomarkers of colon cancer
《Genes & Diseases》2025年第2期98-101,共4页Ruizhi Chang Ganxun Li Guan-nan Jin Bixiang Zhang Ze-yang Ding 
supported by the National Nature Science Foundation of China (No.82273441,81874065);the National Basic Research Program of China (No.2020YFA0710700);the Knowledge Innovation Program of Wuhan-Shuguang Project (China) (No.2022020801020456);Tongji Hospital (HUST)Foundation for Excellent Young Scientist (China) (No.2020YQ05);the First Level of the Public Health Youth Top Talent Project of Hubei Province (China) (No.2022SCZ051).
Despite the improvement of programmatic screening,adjuvant chemotherapy,and curative resection,colon cancer,with increasing incidence and mortality rates,still poses a significant public health challenge as the third ...
关键词：COLON cancer MORTALITY 
Comparison of outcomes of laparoscopic-assisted and total laparoscopic right hemicolectomy for right-sided colon cancer
《World Journal of Gastrointestinal Surgery》2025年第4期75-82,共8页Wen-Feng Du Tang-Shuai Liang Zong-Fei Guo Jian-Jun Li Cheng-Gang Yang 
BACKGROUND Colon cancer is a significant health issue in China,with high incidence and mortality rates.Surgical resection remains the primary treatment,with the introduction of complete mesocolic excision in 2009 impr...
关键词：Laparoscopic complete mesocolic excision Total laparoscopic right hemicolectomy Laparoscopic-assisted right hemicolectomy Right-sided colon cancer Short-term outcomes 
Assessment of new pathological markers in early stage colon cancer:Insights and limitations
《World Journal of Gastrointestinal Oncology》2025年第3期113-121,共9页Bulent Erdogan Fatma Elif UsturalıKeskin ErkanÖzcan Ahmet Küçükarda Ali Kaan Güren Osman Köstek Bekir Muhammet Hacioglu Hilmi Kodaz 
BACKGROUND The decision to administer adjuvant chemotherapy to patients with local stage depends on specific high-risk features that are T4 tumor stage,presence of perineural invasion,lymphovascular invasion,poorly di...
关键词：Colon cancer Early stage Risk factors New pathological markers Tumor-stroma ratio Tumor infiltrating lymphocytes Crohn-like reaction Desmoid reaction Poorly differentiated clusters 
Is intraperitoneal isoperistaltic side-to-side anastomosis a safe surgical procedure in radical colon cancer surgery
《World Journal of Gastrointestinal Oncology》2025年第3期133-143,共11页Bin Wu Jing-Tao Zhu He-Xin Lin Yu-Hua Dai Tian-Sheng Lin An-Le Huang Yi-Nan Chen Yong-Wen Li Hai-Bin Wang Yi-Fu Chen Dong-Han Chen Huang-Dao Yu Jun You Qing-Qi Hong 
Bethune Charitable Foundation Project,No.HZB-20190528-10;Natural Science Foundation of Fujian Province,No.2020J011230.
BACKGROUND Colorectal cancer,one of the most common malignancies,is primarily treated through surgery.With the widespread use of laparoscopy,gastrointestinal reconstruction remains a key area of research.The choice be...
关键词：Colon cancer Laparoscopic surgery Intraperitoneal anastomosis Extraperitoneal anastomosis Isoperistaltic sideto-side anastomosis Hand-sewn 
Incorporation of human β-defensin-1 into immunoliposomes to facilitate targeted autophagy therapy of colon carcinoma
《World Journal of Clinical Oncology》2025年第3期8-12,共5页Ying Huang Xi-Ye Wang Jia-Yue Huang Zheng-Wei Huang 
Supported by National Natural Science Foundation of China,No.82104070;Guangdong Universities Keynote Regions Special Funded Project,No.2022ZDZX2002。
Based on the discovery that humanβ-defensin-1(hBD-1)triggers autophagy in colon cancer cells and inhibits proliferation,we proposed the consideration of its druggability.As a protein,its stability,targetability and b...
关键词：Humanβ-defensin-1 IMMUNOLIPOSOMES Colon cancer SW620 AUTOPHAGY 
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