Colorectal cancer(CRC)is a prevalent malignant tumor,with the global new cases reaching 1.9316 million and deaths reaching 935,200 in 2022.In China,therewere 555,500 new cases of CRC,with an age-standardized incidence...
This work was supported in part by grant NIH-R01CA/DK80982-01 from the National Institutes of Health and a grant the FAMRI.
Background:Despite considerable advances in preoperative imaging,up to one-third of patients operatively explored for hepatic colorectal metastases are unexpectedly found to harbor unresectable intrahepatic or extrahe...
This work was supported by grants from the National Natural Science Foundation of China(81772580);Natural Science Foundation of Guangdong Province,China(2021A1515011705);the Clinical Research Startup Program of Southern Medical University by High-level University Construction Funding of Guangdong Provincial Department of Education(LC2016ZD014).
Dear editor,The tumor microenvironment(TME)heavily impacts disease biology and may influence responses to systemic treatments,and thereby,affects patients’prognosis.In our previous study,we found that immune features...
More than 50%of patients will develop colorectal cancer(CRC)liver metastases(CRCLM)during the course of their disease,while 15-25%of patients will have metastatic disease present at the time of initial diagnosis.Resec...
Management of patients with synchronous colorectal liver metastases(SCRLM)has transformed dramatically over the past 2 decades(1-3).A step-by-step,patient tailored approach as orchestrated by a multidisciplinary tumor...
Adenocarcinoma of the colon and rectum(CRC)is the second leading cause of cancer-related mortality.Surgical resection of disease offers the best long-term survival.Unfortunately,>50%of patients have liver metastases a...
Approximately 25%of individuals with colorectal cancer(CRC)present with metastatic disease,and it is estimated that throughout the course of the disease,up to 50%of individuals may develop liver metastases,the majorit...
We read with great interest the recently published article of Boudjema and collaborators(1).The authors evaluated the safety and efficacy of delayed resection(DR)versus simultaneous resection(SR)for patients with init...
Colorectal cancer(CRC)is the second leading cause of cancer related mortality,though improvements in CRC screening,systemic and local treatment,and surgical technique have steadily won victories in the battle against ...
The liver is the commonest site of metastatic disease for patients with colorectal cancer,with at least 25%developing colorectal liver metastases(CRLM)during the course of their illness.The management of CRLM has evol...