DECITABINE

作品数：42被引量：73H指数：5
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相关领域：医药卫生更多>>
相关作者：王琳许小平曹蕾张浩朱尔佳更多>>
相关机构：台湾神隆股份有限公司复旦大学广东药学院连云港杰瑞药业有限公司更多>>
相关期刊：《Cellular & Molecular Immunology》《当代医学》《药学进展》《Oncology and Translational Medicine》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Decitabine in combination with idarubicin within a modified busulfan/cyclophosphamide conditioning regimen for patients with advanced myelodysplastic syndrome:A prospective multicenter clinical cohort study
《Chinese Medical Journal》2024年第9期1115-1117,共3页Yigeng Cao Mingyang Wang Fuxu Wang Wenwen Guo Yueshen Ma Xiaoyun Li Yi He Aiming Pang Rongli Zhang Weihua Zhai Xin Chen Qiaoling Ma Jialin Wei Donglin Yang Yong Huang Dan Feng Jia Liu Xin Gao Shupeng Wen Wen Wang Tao Wang Ying Li Xiaosheng Fang Yingchun Li Xiaohan Zhang Yun Cai Yongqi Wang Weijie Cao Runqing Lu Sizhou Feng Rong Guo Yuewen Fu Xin Du Zhuogang Liu Xin Wang Ling Wang Liangming Ma Chuanfang Liu Xuejun Zhang Mingzhe Han Erlie Jiang 
supported by grants from the Tianjin Health Science and Technology Project(No.TJWJ2022MS001);Clinical research project of Tianjin Society of Hematology and Regenerative Medicine(No.2022 TSHRM08004);Key Project of Tianjin Natural Science Foundation(No.20JCZDJC00410);CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-073);Haihe Laboratory of Cell Ecosystem Innovation Fund(No.22HHXBSS00034);National Natural Science Foundation of China(Nos.82070192,8230012348,and 82170217)
To the Editor:Allogeneic hemopoietic stem cell transplantation(allo-HSCT)represents the only long-term survival treatment choice for patients with myelodysplastic syndromes(MDS)and MDS/myeloproliferative neoplasm(MPN)...
关键词：REGIMEN myelo PATIENTS 
Efficacy and safety of decitabine combined with low-dose cytarabine, aclarubicin, and granulocyte colony-stimulating factor compared with standard therapy in acute myeloid leukemia patients with TP53 mutation被引量：2
《Chinese Medical Journal》2021年第12期1477-1479,共3页Si-Si Chen Qian Sun Lan Cao Wen-Zhong Wu Yue Xie Chun Qiao Jian-yong Li Si-Xuan Qian Ming Hong 
supported by the National Natural Science Foundation of China(Nos.81870119 and 81720108002);the National Science and Technology Major Project(No.2018ZX09734007);the Clinical Medicine and Technological Development Foundation of Jiangsu University(No.JLY20180072).
Tumor suppressor gene P53(TP53)is a critical tumor suppressor gene.The mutant p53 protein enhances the activity,invasion and metastasis of tumor cells.Acute myeloid leukemia(AML)patients with TP53 mutations respond po...
关键词：TP53 PATIENTS stimulating 
Epigenetic therapies in acute myeloid leukemia: the role of hypomethylating agents, histone deacetylase inhibitors and the combination of hypomethylating agents with histone deacetylase inhibitors被引量：6
《Chinese Medical Journal》2020年第6期699-715,共17页Qing-Yu Xu Li Yu 
This work was supported by grants from the National Natural Science Foundation of China(No.81670162,No.81970151,and No.81470010).
Epigenetic regulation includes changes of DNA methylation and modifications of histone proteins and is essential for normal physiologic functions,especially for controlling gene expression.Epigenetic dysregulation pla...
关键词：Acute MYELOID leukemia DECITABINE 5-AZACYTIDINE HISTONE DEACETYLASE inhibitors Intensive chemotherapy 
Demethylating agent decitabine induces autologous cancer testis antigen specific cytotoxic T lymphocytes in vivo被引量：1
《Chinese Medical Journal》2013年第23期4552-4556,共5页ZHOU Ji-hao YAO Yu-shi WANG Li-xin WANG Jia LI Yong-hui JIANG Meng-meng ZHOU Min-hang GAO Xiao-ning LI Rui-sheng WANG Li-li YU Li 
This work was supported by the grants from the National Basic Research Program of China （No. 2005CB522400）, National Natural Science Foundation of China （Nos. 90919044, 30971297, 81000221 and 81170518）, Capital Medical Development Scientific Research Fund （No. 2007-2040）, National Public Health Grand Research Foundation （No. 201202017） and The Capital of the Public Health Project （No. Z 111107067311070）. Conflict of interest： none.
Background Cancer testis antigens （CTAs） are a novel group of tumor associated antigens.Demethylating agent decitabine was reported to be able to up-regulate CTAs through its hypomethylation mechanism,thus enhance t...
关键词：DECITABINE cancer testis antigens AUTOLOGOUS cytotoxic T lymphocytes 
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