DEGENERATION

作品数：521被引量：1030H指数：13
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相关作者：施杞梁倩倩王拥军侯炜崔学军更多>>
相关机构：上海中医药大学复旦大学青岛大学华中科技大学更多>>
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Microstructural integrity of the locus coeruleus and its tracts reflect noradrenergic degeneration in Alzheimer’s disease and Parkinson’s disease
《Translational Neurodegeneration》2024年第1期963-979,共17页Chen-Pei Lin Irene Frigerio John G.J.M.Bol Maud M.A.Bouwman Alex J.Wesseling Martin J.Dahl Annemieke J.M.Rozemuller Ysbrand D.van der Werf Petra J.W.Pouwels Wilma D.J.van de Berg Laura E.Jonkman 
funded by The Michael J.Fox Foundation(17253).
Background Degeneration of the locus coeruleus(LC)noradrenergic system contributes to clinical symptoms in Alzheimer’s disease(AD)and Parkinson’s disease(PD).Diffusion magnetic resonance imaging(MRI)has the potentia...
关键词：Locus coeruleus Noradrenergic degeneration Alzheimer’s disease Parkinson’s disease Diffusion MRI POST-MORTEM HISTOPATHOLOGY 
Recombinant SMN protein synergizes with spinal muscular atrophy therapy to counteract pathological motor neuron phenotypes
《Translational Neurodegeneration》2024年第1期114-118,共5页Liliana Brambilla Chiara F.Valori Giulia Guidotti Francesca Martorana Claudia Sulmona Lisa Benedetta De Martini Anselmo Canciani Marco Fumagalli Francesca Talpo Gerardo Biella Elisa Di Pasquale Claudio Iacobucci Federico Forneris Haiyan Zhou Daniela Rossi 
supported by AFM-Téléthon(16177,18221,21565 to DR);Associazione Girotondo ODV(to DR)and the“Ricerca Corrente”funding scheme of the Italian Ministry of Health(to the Istituti Clinici Scientifici Maugeri—IRCCS).Research in the FF lab is supported by the Armenise-Harvard Foundation(CDA 2013 to FF);by the Italian Association for Cancer Research(AIRC,MFAG 20075 and Bridge 27004 to FF);by Velux Stiftung(grant 1375 to FF);by the Italian Ministry for Research(MUR)—Dipartimenti di Eccellenza 2018–2022(to the Department of Biology and Biotechnology of the University of Pavia).
Main text Spinal muscular atrophy(SMA)linked to chromosome 5q is an autosomal recessive neuromuscular disease caused by mutations/deletions in the Survival Motor Neuron 1(SMN1)gene,with consequent reductions of the le...
关键词：ATROPHY MUSCULAR DEGENERATION 
Correction:Targeting the overexpressed mitochondrial protein VDAC1 in a mouse model of Alzheimer’s disease protects against mitochondrial dysfunction and mitigates brain pathology
《Translational Neurodegeneration》2023年第1期889-889,共1页Ankit Verma Anna Shteinfer-Kuzmine Nikita Kamenetsky Srinivas Pittala Avijit Paul Edna Nahon Crystal Alberto Ouro Vered Chalifa-Caspi Swaroop Kumar Pandey Alon Monsonego Noga Vardi Shira Knafo Varda Shoshan-Barmatz 
Correction:Translational Neurodegeneration(2022)11:58 https://doi.org/10.1186/s40035-022-00329-7 Following publication of this article[1],the authors iden-tified an error in the family name of Alon Monsonego.The incor...
关键词：CORRECT DEGENERATION VDAC1 
Novel data-driven subtypes and stages of brain atrophy in the ALS-FTD spectrum
《Translational Neurodegeneration》2023年第1期50-69,共20页Ting Shen Jacob W.Vogel Jeffrey Duda Jeffrey S.Phillips Philip ACook James Gee Lauren Elman Colin Quinn Defne A.Amado Michael Baer Lauren Massimo Murray Grossman David J.Irwin Corey T.McMillan 
JWV acknowledges funding from the NIH(T32MH019112);the SciLifeLab&Wallenberg Data Driven Life Science Program(Grant:KAW 2020.0239);Jeffrey S.Phillips was supported by NIH Grant(R01-AG054519,K01-AG061277);supported by NIH funding(P30 AG072979,P01AG066597,R01NS109260);Penn Institute on Aging,Robinson Family Fund,Peisach Family Fund for FTD Research,and Arking Family Fund.
Background TDP-43 proteinopathies represent a spectrum of neurological disorders,anchored clinically on either end by amyotrophic lateral sclerosis(ALS)and frontotemporal degeneration(FTD).The ALS-FTD spectrum exhibit...
关键词：Amyotrophic lateral sclerosis Frontotemporal degeneration Disease heterogeneity SuStaIn model 
Correction:Links between COVID-19 and Parkinson’s disease/Alzheimer’s disease:reciprocal impacts,medical care strategies and underlying mechanisms被引量：2
《Translational Neurodegeneration》2023年第1期572-573,共2页Pei Huang Lin-Yuan Zhang Yu-Yan Tan Sheng-Di Chen 
Correction to:Translational Neurodegeneration(2023)12:5 https://doi.org/10.1186/s40035-023-00337-1 Following publication of this article[1],three errors were identified about the reference.Correction 1:136.Crocker TF,...
关键词：DEGENERATION ALZHEIMER reciprocal 
Correction:Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia被引量：1
《Translational Neurodegeneration》2023年第1期575-575,共1页Nuole Zhu Miguel Santos-Santos Ignacio Illán-Gala Victor Montal Teresa Estellés Isabel Barroeta Miren Altuna Javier Arranz Laia Muñoz Olivia Belbin Isabel Sala Maria Belén Sánchez-Saudinós Andrea Subirana Laura Videla Jordi Pegueroles Rafael Blesa Jordi Clarimón Maria Carmona-Iragui Juan Fortea Alberto Lleó Daniel Alcolea 
Correction:Translational Neurodegeneration(2021)10:50 https://doi.org/10.1186/s40035-021-00275-w Following publication of this article[1],the below fund-ing information is missing.European Union’s Horizon 2020,’MES-...
关键词：DEGENERATION ACIDIC PLASMA 
Retraction Note: Alpha-synuclein overexpression in the olfactory bulb initiates prodromal symptoms and pathology of Parkinson’s disease
《Translational Neurodegeneration》2022年第1期443-443,共1页Haichen Niu Lingyu Shen Tongzhou Li Chao Ren Sheng Ding Lei Wang Zhonghai Zhang Xiaoyu Liu Qiang Zhang Deqin Geng Xiujuan Wu Haiying Li 
Retraction Note:Translational Neurodegeneration(2018)7:25 https://doi.org/10.1186/s40035-018-0128-6 The Editor-in-Chief has retracted this article.After pub-lication,concerns were raised regarding image overlap across...
关键词：DEGENERATION Alpha stated 
Correction:Clinical outcome measures in dementia with Lewy bodies trials:critique and recommendations
《Translational Neurodegeneration》2022年第1期588-588,共1页Federico Rodriguez-Porcel Kathryn A.Wyman-Chick Carla Abdelnour Ruiz Jon B.Toledo Daniel Ferreira Prabitha Urwyler Rimona S.Weil Joseph Kane Andrea Pilotto Arvid Rongve Bradley Boeve John-Paul Taylor Ian McKeith Dag Aarsland Simon J.G.Lewis the Lewy Body Dementias Clinical Trials Workgroup from the Lewy Body Dementias Professional Interest Area-Alzheimer’s Association International Society to Advance Alzheimer’s Research and Treatment(ISTAART) 
Correction to:Translational Neurodegeneration(2022)11:24 https://doi.org/10.1186/s40035-022-00299-w Following publication of the original article[1],the authors identified some errors in the Additional files 1-5.The o...
关键词：DEGENERATION CLINICAL measures 
Molecular targets for modulating the protein translation vital to proteostasis and neuron degeneration in Parkinson’s disease被引量：3
《Translational Neurodegeneration》2019年第1期63-76,共14页Zhi Dong Zhou Thevapriya Selvaratnam Ji Chao Tristan Lee Yin Xia Chao Eng-King Tan 
The Singapore National Medical Research Council(NMRC)grants including STaR and a clinical translational research program in Parkinson’s disease.
Parkinson’s disease(PD)is the most common neurodegenerative movement disorder,which is characterized by the progressive loss of dopaminergic neurons in the Substantia Nigra pars compacta concomitant with Lewy body fo...
关键词：Molecular targets Neuron degeneration Parkinson’s disease Protein aggregation Protein translation PROTEOSTASIS 
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