In the United States,a patient is‘legally blind’if the best corrected vision in‘both eyes’is 20/200(0.1)or less or the peripheral visual field is less than 20°from the central fixation(1).It could be from advance...
Background:Axonal degeneration caused by damage to the optic nerve can result in a gradual death of retinal ganglion cells(RGC),leading to irreversible vision loss.An example of such diseases in humans includes optic ...
Objective:In this review,non-transgenic models of age-related macular degeneration(AMD)are discussed,with focuses on murine retinal degeneration induced by sodium iodate and lipid peroxide(HpODE)as preclinical study p...
supported by the National Institutes of Health(R01EY027827,QX)and VCU(VETAR 2021,YO)grants.
Background:Sodium iodate(SI)is a chemical widely applied to induce retina degeneration in animal models.SI treatment caused formation of rosettes/folds in the outer nuclear layer(ONL)of the rat retina,but it was previ...
Reticular pseudodrusen(RPD)represents a distinct phenotype of age-related macular degeneration(AMD)that is characterized by worse macular function and an overall greater occurrence of development of both forms of late...
Age-related macular degeneration(AMD)is considered one of the principal causes of vision impairment among older individuals in developed countries.Assuming this,new technologies which may increment insights elucidatin...
Background:The loss of cell polarity plays a key part in retinal dystrophies such as retinitis pigmentosa(RP)and Leber congenital amaurosis(LCA),resulting in photoreceptor(PR)degeneration and vision loss.Despite not k...
We were very pleased by the paper of Borrelli and colleagues(1)and we would thank for their consideration.Nowadays,macular diseases,such as age-related macular degeneration(AMD)underwent a strong improvement in terms ...
Age-related macular degeneration(AMD)is a sight-threatening disease and responsible for 8.7%of blindness globally(1).Neovascular AMD(nAMD)is characterized by abnormal angiogenesis with these atypical vessels leaking,r...
Population ageing is a pervasive and enduring global phenomenon with profound implications in many facets of the human life.Because the prevalence and morbidity associated with cataracts and age-related macular degene...