DISTINCT

作品数：480被引量：1115H指数：14
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相关机构：昆明医科大学浙江大学江西省水利科学研究院贵州大学更多>>
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The scRNA-sequencing landscape of pancreatic ductal adenocarcinoma revealed distinct cell populations associated with tumor initiation and progression
《Genes & Diseases》2025年第3期447-462,共16页Ying Wang Zhouliang Bian Lichao Xu Guangye Du Zihao Qi Yanjie Zhang Jiang Long Wentao Li 
supported by grants from the National Natural Science Foundation of China(No.82272095 to W.L.,82072638 to Y.Z.and 82002537 to Z.Q.);supported by grants from Zhangjiang National Innovation Demonstration Zone(Shanghai,China)(No.ZJ2021-ZD-007 to W.L.);the Biobank Program of Shanghai Ninth People’s Hospital,Shanghai Jiao Tong University School of Medicine(Shanghai,China)(No.YBKB202217 to Y.Z.).
Pancreatic ductal adenocarcinoma (PDAC) stands as a formidable malignancy characterized by its profound lethality. The comprehensive analysis of the transcriptional landscape holds immense significance in understandin...
关键词：Acinar-to-ductal metaplasia Lymph node metastasis Pancreatic ductal adenocarcinoma Single-cell RNA sequencing Tumor microenvironment 
Pdgfrα+stromal cells,a key regulator for tissue homeostasis and dysfunction in distinct organs
《Genes & Diseases》2025年第2期181-201,共21页Xia Kang Kun Zhao Zhu Huang So-ichiro Fukada Xiao-wei Qi Hongming Miao 
supported by grants from the National Natural Science Foundation of China (No.82173134 to H.M.);the Sichuan Science and Technology Program (China) (No.2023ZYD0061 to X.K.);the funding of Jinfeng Laboratory (Chongqing,China);China Postdoctoral Science Foundation (No.2020M673648 to X.K.);Chongqing Postdoctoral Science Special Foundation (China) (to X.K.);Chongqing Science and Technology Bureau (China) (No.CSTB2022TIADKPX0168 to X.Q.).
Pdgfra+stromal cells are a group of cells specifically expressing Pdgfra,which may be mentioned with distinct names in different tissues.Importantly,the findings from numerous studies suggest that these cells share ex...
关键词：Fatty infiltration FIBROSIS Pdgfra^(+)stromal cell Tissue degeneration Tissue regeneration 
Parametric study to implement a water-weakening process in UDEC
《Journal of Rock Mechanics and Geotechnical Engineering》2025年第3期1378-1386,共9页Fengchang Bu Michel Jaboyedoff Marc-Henri Derron Lei Xue Yuan Cui Chao Xu 
supported by the National Natural Science Foundation of China under Grant Nos.41977249 and 42090052;the China Scholarship Council under file No.202204910040.
Despite the prevalence and validity of the universal distinct element code(UDEC)in simulations in geotechnics domain,water-weakening process of rock models remains elusive.Prior research has made positive contribution...
关键词：Parametric analysis Universal distinct element code(UDEC) Water-weakening Rock strength 
Distinct association of HRAS and KRAS with Mn^(2+) ion illustrated by paramagnetic NMR
《Magnetic Resonance Letters》2025年第1期22-31,共10页Jia-Liang Chen Xun-Cheng Su 
supported by the Ministry of Science and Technology of China(2021YFA1600304);the National Natural Science Foundation of China(22161142018,21991081,22174074 and 22374126).
Rat sarcoma virus oncogene(RAS)proteins are of crucial oncogenic proteins and are involved in several essential intracellular processes.The RAS protein has an intrinsic metal binding site for Mg^(2+),which is importan...
关键词：HRAS KRAS Mn^(2+) NMR PRE 
Thermal Performance of Entropy-Optimized Tri-Hybrid Nanofluid Flow within the Context of Two Distinct Non-Newtonian Models:Application of Solar-Powered Residential Buildings
《Computer Modeling in Engineering & Sciences》2025年第3期3089-3113,共25页Ahmed Mohamed Galal Adebowale Martins Obalalu Akintayo Oladimeji Akindele Umair Khan Abdulazeez Adebayo Usman Olalekan Adebayo Olayemi Najiyah Safwa Khashi’ie 
funded by Universiti Teknikal Malaysia Melaka through the Tabung Penerbitan Jurnal(S11017).
The need for efficient thermal energy systems has gained significant attention due to the growing global concern about renewable energy resources,particularly in residential buildings.One of the biggest challenges in ...
关键词：Cattaneo-Christov heat flux solar power systems ternary hybrid nanofluid maxwell fluid 
Rethinking BCG vaccine delivery for enhanced efficacy:Are two distinct routes of BCG administration better than one?
《hLife》2025年第2期61-63,共3页Raymond Moeketsi Moseki Melissa Dalcina Chengalroyen 
supported by the Fogarty HIV-associated TB training Program Fellowship(to R.M.M.);the Faculty of Health Science Start Up Emerging Researcher Award(to M.D.C);supported by the Fogarty International Center of the National Institutes of Health and the Eunice Kennedy ShriverNational Institute of Child Health&Human Development(D43 TW010559).
Despite the availability of effective tuberculosis(TB)treatments,the extended duration of therapy poses significant challenges to patient adherence.Vaccination remains a significant public healthcare milestone and cou...
关键词：CHEMOTHERAPY VACCINE SPITE 
BMAL1/PGC1α4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exercise
《Journal of Sport and Health Science》2025年第1期107-129,共23页Mingwei Guo Fei Shen Xiaozhen Guo Jun Zhang Ying Ma Xia Wu Hui Zuo Jing Yao Yepeng Hu Dongmei Wang Yu Li Jin Li Jin Qiu Jian Yu Meiyao Meng Ying Zheng Xin Chen Mingkai Gong Kailin Liu Ling Jin Xiangyu Ren Qiang Zhang Yu Zhao Xuejiang Gu Feixia Shen Dali Li Liangcai Gao Chang Liu Fei Zhou Mian Li Jiqiu Wang Shuzhe Ding Xinran Ma Jian Lu Cen Xie Junjie Xiao Lingyan Xu 
supported by funds from National Key Research and Development Program of China (2019YFA0904500 to LX, 2023YFA1800400 to LX, and 2018YFE0113500 to JX);the National Natural Science Foundation of China (82301777 to MG, 32222024 to LX, 32325024 to XM, 32071148 to LX, and 91957116 to CX);Fundamental Research Funds for the Central Universities, Science and Technology Commission of Shanghai Municipality (21140904300 to XM and 22ZR1421200 to LX);Innovation Program of Shanghai Municipal Education Commission (2017-01-07-00-09-E00042 to JX);Key Project of 2022 Higher Education Scientific Research Planning Project of China Association of Higher Education (22TY0218 to FS);Youth Fund for Humanities and Social Sciences Research of the Ministry of Education (22YJC890023 to FS);Postdoctoral Fellowship Program of CPSF (GZB20230219 to MG);China Postdoctoral Science Foundation (2023M741183 to MG);ECNU public platform for Innovation (011).
Background: Resistance exercise leads to improved muscle function and metabolic homeostasis.Yet how circadian rhythm impacts exercise outcomes and its molecular transduction remains elusive.Methods: Human volunteers w...
关键词：Daily variance CIRCADIAN Muscle strength Metabolic benefits Resistance exercise 
Distinct tropisms of HCMV and SARS-CoV-2 in lung tissue of a patient with advanced HIV disease
《Virologica Sinica》2025年第1期141-143,共3页Jingjing Xu Bo Yang Ye Zheng Yuexiang Yang Min-Hua Luo Yun Ling Xiaohong Fan Han Cheng 
National Key Research and Development Project of China(2023YFC2306600);Key Program of the National Natural Science Foundation of China(82430070);Shanghai Pujiang Program(No.23PJ1410800);National Natural Science Foundation of China(82072260,32370168);Eastern Talent Plan Leading Project,Shanghai Hospital Development Center Foundation(SHDC12022121);Shanghai 2020“Science and Technology Innovation Action Plan”Medical Innovation Research Special(20Z11900900);Three-year Action Plan(2023-2025);Key Discipline Program on Public Health System Construction of Shanghai(GWVI-11.1-15);Construction of the Major Infectious Disease Medical Treatment System(GWVI-2.2).
Dear Editor,The COVID-19 pandemic,caused by the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has resulted in millions of deaths worldwide.It poses significant challenges in the management of immunocompr...
关键词：Immunocompromised patients severe acute respiratory syndrome coronavirus Lung tissue TROPISMS HCMV cohort studies SARS CoV HIV 
Exploring Distinct Ethical Challenges Deriving from AI-RPA Technical Characteristics
《Journal of Computer and Communications》2025年第2期16-27,共12页Jelle Tuls 
Addressing the existing gap in ethical research surrounding distinct technical characteristics of Robotic Process Automation enhanced with Artificial Intelligence (AI-RPA), this analysis examines the unique ethical di...
关键词：Robotic Process Automation Artificial Intelligence AI-RPA Digital Ethics Distinct Characteristics 
Clinicopathological and molecular features of HR^(+)/HER2^(−)breast cancer patients with distinct endocrine resistance patterns
《Chinese Journal of Cancer Research》2025年第1期48-65,共18页Siwei Zhang Han Wang Hang Zhang Qingyuan Zhuang Xiaohui Zhu Yi Xiao Yizhou Jiang 
supported by the National Key Research and Development Program of China(No.2020YFA0112304);the National Natural Science Foundation of China(No.82373167,82341003 and 92159301);the Natural Science Foundation of Shanghai(No.22ZR1479200);the Shanghai Key Laboratory of Breast Cancer(No.12DZ2260100);the SHDC Municipal Project for Developing Emerging and Frontier Technology in Shanghai Hospitals(No.SHDC12021103);Shanghai Medical Innovation Research Project(No.22Y11912700),and Shanghai Anticancer Association EYAS PROJECT(No.SACA-CY22A05).
Objective:Recurrence continues to be a pivotal challenge among hormone receptor-positive(HR^(+))/human epidermal growth factor receptor 2^(−)negative(HER2^(−))breast cancers.In the international consensus guidelines,H...
关键词：HR^(+)/HER2^(−)breast cancer endocrine resistance cancer recurrence multiomics analysis precise treatment 
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