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Pdgfrα+stromal cells,a key regulator for tissue homeostasis and dysfunction in distinct organs
《Genes & Diseases》2025年第2期181-201,共21页Xia Kang Kun Zhao Zhu Huang So-ichiro Fukada Xiao-wei Qi Hongming Miao 
supported by grants from the National Natural Science Foundation of China (No.82173134 to H.M.);the Sichuan Science and Technology Program (China) (No.2023ZYD0061 to X.K.);the funding of Jinfeng Laboratory (Chongqing,China);China Postdoctoral Science Foundation (No.2020M673648 to X.K.);Chongqing Postdoctoral Science Special Foundation (China) (to X.K.);Chongqing Science and Technology Bureau (China) (No.CSTB2022TIADKPX0168 to X.Q.).
Pdgfra+stromal cells are a group of cells specifically expressing Pdgfra,which may be mentioned with distinct names in different tissues.Importantly,the findings from numerous studies suggest that these cells share ex...
关键词：Fatty infiltration FIBROSIS Pdgfra^(+)stromal cell Tissue degeneration Tissue regeneration 
Parametric study to implement a water-weakening process in UDEC
《Journal of Rock Mechanics and Geotechnical Engineering》2025年第3期1378-1386,共9页Fengchang Bu Michel Jaboyedoff Marc-Henri Derron Lei Xue Yuan Cui Chao Xu 
supported by the National Natural Science Foundation of China under Grant Nos.41977249 and 42090052;the China Scholarship Council under file No.202204910040.
Despite the prevalence and validity of the universal distinct element code(UDEC)in simulations in geotechnics domain,water-weakening process of rock models remains elusive.Prior research has made positive contribution...
关键词：Parametric analysis Universal distinct element code(UDEC) Water-weakening Rock strength 
Distinct association of HRAS and KRAS with Mn^(2+) ion illustrated by paramagnetic NMR
《Magnetic Resonance Letters》2025年第1期22-31,共10页Jia-Liang Chen Xun-Cheng Su 
supported by the Ministry of Science and Technology of China(2021YFA1600304);the National Natural Science Foundation of China(22161142018,21991081,22174074 and 22374126).
Rat sarcoma virus oncogene(RAS)proteins are of crucial oncogenic proteins and are involved in several essential intracellular processes.The RAS protein has an intrinsic metal binding site for Mg^(2+),which is importan...
关键词：HRAS KRAS Mn^(2+) NMR PRE 
Rethinking BCG vaccine delivery for enhanced efficacy:Are two distinct routes of BCG administration better than one?
《hLife》2025年第2期61-63,共3页Raymond Moeketsi Moseki Melissa Dalcina Chengalroyen 
supported by the Fogarty HIV-associated TB training Program Fellowship(to R.M.M.);the Faculty of Health Science Start Up Emerging Researcher Award(to M.D.C);supported by the Fogarty International Center of the National Institutes of Health and the Eunice Kennedy ShriverNational Institute of Child Health&Human Development(D43 TW010559).
Despite the availability of effective tuberculosis(TB)treatments,the extended duration of therapy poses significant challenges to patient adherence.Vaccination remains a significant public healthcare milestone and cou...
关键词：CHEMOTHERAPY VACCINE SPITE 
Exploring Distinct Ethical Challenges Deriving from AI-RPA Technical Characteristics
《Journal of Computer and Communications》2025年第2期16-27,共12页Jelle Tuls 
Addressing the existing gap in ethical research surrounding distinct technical characteristics of Robotic Process Automation enhanced with Artificial Intelligence (AI-RPA), this analysis examines the unique ethical di...
关键词：Robotic Process Automation Artificial Intelligence AI-RPA Digital Ethics Distinct Characteristics 
Distinct MLT asymmetry of auroral kilometric radiation observed by the FAST satellite
《Earth and Planetary Physics》2025年第1期188-193,共6页JiaWen Tang Sai Zhang FuLiang Xiao HongMing Yang Si Liu YiHua He Chang Yang YuYue Jin ZhouKun Deng Ping Li Archie James Johnston 
supported by the National Natural Science Foundation of China grants 42230209,42374215,42304183,72342001,71931003 and 72061147004;the Scientific Research Fund of Hunan Provincial Education Department grants 21A0212;the Science and Technology Innovation Program of Hunan Province under Grants 2022RC4025,2023JJ50312,2023JJ50010.
Auroral Kilometric Radiation (AKR) is a common radio emission,which can contribute to the magnetosphere-ionosphereatmosphere co u pling.Similar emissions have been observed in all magnetic planet magnetospheres of the...
关键词：asymmetry auroral kilometric radiation interplanetary magnetic field 
Distinct responses of climate-growth and iWUE in Fagus sylvatica L.at two low elevation sites in southern Italy
《Journal of Forestry Research》2025年第1期275-291,共17页Jerzy Piotr Kabala Francesco Niccoli Simona Altieri Iqra Liyaqat Giovanna Battipaglia 
In this study,using a dendrological and isotopic approaches,we investigated the responses to climate of two pure Fagus sylvatica L.stands(Campobraca and Falode)in the southernmost part of the distribution range in sou...
关键词：Intrinsic water use efficiency Tree rings Stable isotope analysis Climate change European beech 
Canonical and noncanonical NOTCH signaling in the nongenetic resistance of cancer:distinct and concerted control
《Frontiers of Medicine》2025年第1期23-52,共30页Xianzhe Huang Wenwei Chen Yanyan Wang Dmytro Shytikov Yanwen Wang Wangyi Zhu Ruyi Chen Yuwei He Yanjia Yang Wei Guo 
supported by the National Natural Science Foundation of China(Nos.81974455,8217110405,and 82173351);the National Key Research and Development Program of China(No.2018YFA0107800);the Zhejiang University Startup Fund for Dr.Wei Guo.Special thanks also go to the Mu Xian Hua Stem Cells and Cancer Resistance Fund.
Therapeutic resistance in cancer is responsible for numerous cancer deaths in clinical practice.While target mutations are well recognized as the basis of genetic resistance to targeted therapy,nontarget mutation resi...
关键词：canonical NOTCH signaling noncanonical NOTCH signaling nongenetic resistance of cancer cancer stemlike cells epithelial-to-mesenchymal transition drug-tolerant persisters NOTCH inhibitors 
Impact of setting distinct target blood glucose levels on endogenous insulin suppression and pharmacodynamics of insulin preparations
《World Journal of Diabetes》2025年第2期47-54,共8页Hui Liu Ting Li Xin-Lei Chen Hong-Ling Yu Ye-Rong Yu 
This retrospective analysis incorporated data from two clinical trials(CTR20220854 and CTR20222843);sponsored by Chongqing Chenan Biopharmaceutical Co.,Ltd.and Jiangsu Hengrui Pharmaceuticals Co.,Ltd.However,these sponsors did not partake in the study design,data interpretation,or manuscript preparation.
BACKGROUND Insulin therapy plays a crucial role in managing diabetes.Regulatory guidelines mandate assessing the pharmacokinetics(PK)and pharmacodynamics(PD)of new insulin formulations with euglycemic clamp techniques...
关键词：Euglycemic clamp Target glucose setting Healthy subject C-PEPTIDE PHARMACODYNAMICS Endogenous insulin secretion 
Nanoplastics and nano-ZnO facilitate Cd accumulation in zebrafish larvae via a distinct pathway:Revelation by LA-ICP-MS imaging
《Chinese Chemical Letters》2025年第2期408-412,共5页Pengyu Chen Beibei Chen Man He Yuxi Zhou Lei Lei Jian Han Bingsheng Zhou Ligang Hu Bin Hu 
financially supported by the National Natural Science Foundation of China(NSFC,Nos.22174103 and 21575107)。
The interaction between nanoparticles (NPs) and pollutants affects their bioavailability and toxicity.However,the processes by which NPs and pollutants change in vivo have rarely been explored.Here,using laser ablatio...
关键词：LA-ICP-MS Nanoplastics ZnO nanoparticles CADMIUM Combined effect Zebrafish larvae 
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