DNA-BINDING

作品数：62被引量：206H指数：6
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MYC promotes global transcription in part by controlling P-TEFb complex formation via DNA-binding independent inhibition of CDK9 SUMOylation被引量：1
《Science China(Life Sciences)》2023年第9期2167-2184,共18页Qingqing Guan Zhaosu Chen Fang Yu Lingling Liu Yuanyong Huang Gang Wei Cheng-Ming Chiang Jiemin Wong Jiwen Li 
supported by the National Natural Science Foundation of China (32070643, 32130051, 31961133009);Science and Technology Commission of Shanghai Municipality (20JC1411500);the ECNU Public Platform for Innovation (011);the Instruments Sharing Platform of the School of Life Sciences,East China Normal University;supported by the US National Institutes of Health (NIH) grant 1RO1CA251698-01;Cancer Prevention and Research Institute of Texas (CPRIT) grant RP190077。
MYC is an oncogenic transcription factor with a novel role in enhancing global transcription when overexpressed. However, how MYC promotes global transcription remains controversial. Here, we used a series of MYC muta...
关键词：MYC global transcription P-TEFB CDK9 SUMOYLATION cell transformation 
The expression of tga1a gene from tobacco affects the expression of exogenous gene in transgenic plant被引量：1
《Science China(Life Sciences)》2003年第2期141-152,共12页路子显 常团结 李旭刚 徐军望 李慧芬 陈宛新 冯德江 肖桂芳 朱祯 
This work was supported by the National Natural Science Foundation of China (Grant Nos.39980024;39880023&39989001);heHighTechnology Research and DevelopmentProgramofChina2001AA212041;2001AA222251; 101-06-01-06) and the National Key Fundamental Resear
The DNA-binding protein TGA1a of tobacco can specially interact with the enhancer sequence as-1 (- 83 to - 63) of CaMV35S promoter and show the function of transcriptional acti-vation. In order to study the expression...
关键词：GENE EXPRESSION and regulation  DNA-BINDING protein TGA1a  plant transformation  REPORTER gene. 
Effect of thermal injury on LPS-mediated Toll signaling pathways by murine peritoneal macrophages:inhibition of DNA-binding of transcription factor AP-1 and NF-κB and gene expression of c-fos and IL-12p40
《Science China(Life Sciences)》2002年第6期613-622,共10页王兴宇 李昌麟 张劲松 冯卫国 苏踊跃 张宗梁 
This work was supported by the Ministry of Science and Technology of China
Thermal injury is able to induce the immune functional inhibition in the host, but the mechanisms are largely unknown. The available evidence indicates that macrophages play an important role in immune regulations and...
关键词：thermal injury  AP-1  NF-кB  macrophages. 
Synthesis and DNA-binding ability of Spl protein zinc finger domain and its peptidomimetics
《Science China(Life Sciences)》1997年第5期518-523,共6页王锐 倪京满 胡晓愚 马亚平 李向群 杨顶建 董守良 杨晓武 潘鑫复 
Project supported by the Fok Ying Tung Education Foundation, the National Natural Science Foundation of China, and the State Education Commission of China.
The second zinc finger fragment of Sp1 (Spl-ZF2), its mutant (Spl-ZF2/HT. E20→H, R23→T), and two mimic analogues (ZF20 and ZF15) were synthesized by stepwise solid phase technique. The CD spectra and UV-visible spec...
关键词：zinc FINGER domain SP1 protein solid phase peptide SYNTHESIS sequence specifically oligonucleotide. 
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