This study was funded in part by the project of Nanjing Infectious Disease Clinical Medical Center and the project of Innovation center for infectious disease of Jiangsu Province(NO.CXZX202232);the Jiangsu Provincial Health Commission Medical Research Foundation(No.M2022030);the Nanjing Medical Science and Technique Development Foundation(No.ZKX21037);the Research Project of Nantong Municipal Health Commission(No.MS2023077).
To the Editor:China provides free antiretroviral therapy(ART)for people with human immunodeficiency virus(HIV),typically using two nucleoside reverse transcriptase inhibitors(NRTIs)and one non-nucleoside reverse trans...
Objective To analyze the efficacy and safety of integrase inhibitor-based single-tablet regimens bictegravir/emtricitabine/tenofovir alafenamide (B/F/TAF) and lamivudine/dolutegravir (3TC/DTG) in the treatment-naive p...
supported by the Gilead Sciences and the Capital Health Research and Development of Special Fund(No.2022-1G-3015)
Background:Antiretroviral therapy(ART)was often associated with dyslipidemia among human immunodeficiency virus(HIV)/acquired immunodeficiency syndrome(AIDS)patients.This study aimed to assess treatment-naïve adult ma...
Background:Dual regimen dolutegravir(DTG)plus lamivudine(3TC)has demonstrated non-inferior efficacy compared to DTG-based three-drug regimens(3DRs),yet directly comparative data regarding the efficacy and safety of DT...
supported by the Research project of Hunan Provincial Department of Science and Technology(No.2020SK21361)
To the Editor:Human immunodeficiency virus(HIV)epidemic poses a significant challenge to global public health.As of 2022,approximately 39.0 million people worldwide were living with HIV.[1]With the ongoing evolution o...
Background:Effective two-drug regimens could decrease long-term drug exposure and toxicity with HIV-1 antiretroviral therapy(ART).We therefore aimed to evaluate the efficacy and safety of a two-drug regimen compared w...
Gilead Sciences, including provision of the study drug, and the Capital Health Research and Development of Special Fund(No. 2022-1G-3015)。
Background: Single-tablet regimen (STR) provides a convenient once-daily regimen for the prevention of human immunodeficiency virus (HIV) infection. Here, we investigated the safety and tolerability of coformulated bi...
This work was funded by grants from the Tianjin Key Medical Discipline (Specialty) Construction Project (No. ZD02);the Tianjin Science and Technology Cultivation Project (No. RC20019)。
To the Editor:With recent advances in antiretroviral therapy(ART)regimens,many patients may benefit from switching drugs.The new combination drug,elvitegravir/cobicistat/emtricitabine/tenofovir(E/C/F/TAF),has been app...
the 13th Five-year National Major Project for HIV/AIDS and Hepatitis B Control and Prevention and the Chinese Ministry of Science and Technology(No.2017ZX10202102005004).
Background:Central nervous system(CNS)symptoms after efavirenz(EFV)treatment in people living with human immunodeficiency virus(HIV)could persist and impact their quality of life.We assessed the impact of EFV-based re...
This work was supported by the grants from the Capital’s Funds for Health Improvement and Research(No.2018-2-2174);Scientific Research Common Program of the Beijing Municipal Commission of Education(No.KM201810025029);the Beijing Municipal Science&Technology Commission(No.Z191100006619060)。
To the Editor:There are 1.25 million people living with human immunodeficiency virus(HIV)(PLWH)in China,with more than 135,000 newly diagnosed cases in 2018.[1]HIV-positive patients who suffer a fracture have extremel...