Supported by the National Natural Science Foundation of China,No.82270594;the National Natural Science Foundation for Youths of China,No.82103151;the Outstanding Youth Foundation of Hunan Province,No.2022JJ20092;the Wisdom Accumulation and Talent Cultivation Project of Third Xiangya Hospital of Central South University,No.YX202103.
BACKGROUND Effective acid suppression significantly enhances the eradication rate of Helicobacter pylori(H.pylori).AIM To assess the efficacy and safety of high-dose dual therapy(HDDT)utilizing various highly potent a...
Objective:To observe the clinical effect of emergency interventional therapy for patients with acute severe non-variceal upper gastrointestinal bleeding.Methods:78 patients with acute severe non-variceal upper gastroi...
This study is registered at ClinicalTrials.gov.The registration identification number is NCT03736369。
BACKGROUND Fexuprazan,a novel potassium-competitive acid blocker,reversibly suppresses the K+/H+-ATPase enzyme in proton pumps within gastric parietal cells.Fexuprazan’s suppression of gastric acid was maintained in ...
Objective: to compare the clinical efficacy of esomeprazole and omeprazole in treating gastric ulcer. Methods: a total of 80 patients with gastric ulcer in our hospital from October 2019 to September 2021 were selecte...
Objective: to compare and analyze the pharmacological effects, therapeutic effects and drug safety of different proton pump inhibitors (PPI) in the treatment of gastric ulcer patients. Methods: according to the random...
Objective: to summarize the implementation effect of esomeprazole and the effect of effective treatment on the patient's serum index. Methods: in January of 2019 to December of this year, 98 patients coming to our hos...
BACKGROUND The pharmacokinetics and bioequivalence of esomeprazole in healthy Chinese subjects and the effects of food on the pharmacokinetics have not been well studied.AIM To evaluate the pharmacokinetic characteris...
National Natural Science Foundation of China;grant number 81900535
Esomeprazole,one of the proton pump inhibitors(PPIs),has been widely used in acid-related diseases,such as gastro-esophageal reflux disease and Helicobacter pylori infection.Compared with other PPIs,esomeprazole has h...
Supported by Shandong Provincial Medical and Health Technology Development Project,No.2014ws0020
BACKGROUND Reflux esophagitis(RE) is a common digestive disorder, and its frequent recurrences cause significant physical pain and are financially burdensome to patients. However, studies on the natural history of tre...