ESSENTIAL

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How did a novel X-linked gene become essential for male determination?
《Cell Research》2022年第1期7-8,共2页Scott William Roy 
A new study reports a necessary role in male sex determination for the X-linked gene SDX.Remarkably,scrutiny reveals that SDX evolved long after the male-determining gene SRY,raising the question of how a new gene cou...
关键词：process. DETERMINATION ANCIENT 
Mitochondrial metabolism and glutamine are essential for mesoderm differentiation of human pluripotent stem cells
《Cell Research》2019年第7期596-598,共3页Vivian Lu Perrine Dahan Fasih M. Ahsan Alexander N. Patananan Irena J. Roy Alejandro Torres Jr Robert M. T. Nguyen Dian Huang Daniel Braas Michael A. Teitell 
Human pluripotent stem cells (hPSCs) generate energy mainly by aerobic glycolysis, with glutamine oxidation in the tricarboxylic acid (TCA) cycle providing additional ATP required for survival.1,2,3 During the exit fr...
关键词：cells AEROBIC CONSENSUS 
Vitamin B12 modulates Parkinson’s disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection被引量：8
《Cell Research》2019年第4期313-329,共17页Adam Schaffner Xianting Li Yacob Gomez-Llorente Emmanouela Leandrou Anna Memou Nicolina Clemente Chen Yao Farinaz Afsari Lianteng Zhi Nina Pan Keita Morohashi Xiaoluan Hua Ming-Ming Zhou Chunyu Wang Hui Zhang Shu G.Chen Christopher J.Elliott Hardy Rideout Iban Ubarretxena-Belandia Zhenyu Yue 
Missense mutations in Leucine-Rich Repeat Kinase 2(LRRK2)cause the majority of familial and some sporadic forms of Parkinson’s disease(PD).The hyperactivity of LRRK2 kinase induced by the pathogenic mutations underli...
关键词：ESSENTIAL effects release FORMS MOUSE ATP can be 
A programmed wave of uridylation-primed mRNA degradation is essential for meiotic progression and mammalian spermatogenesis被引量：2
《Cell Research》2019年第3期221-232,共12页Marcos Morgan Yuka Kabayama Christian Much Ivayla Ivanova Monica Di Giacomo Tatsiana Auchynnikava Jack Michael Monahan Dimitrios Michael Vitsios Lina Vasiliauskaite Stefano Comazzetto Juri Rappsilber Robin Campbell Allshire Bo Torben Porse Anton James Enright Donal O'Carroll 
Several developmental stages of spermatogenesis are transcriptionally quiescent which presents major challenges associated with the regulation of gene expression. Here we identify that the zygotene to pachytene transi...
关键词：programmed WAVE MRNA 
Destabilization of linker histone H1.2 is essential for ATM activation and DNA damage repair被引量：4
《Cell Research》2018年第7期756-770,共15页Zhiming Li Yinglu Li Ming Tang Bin Peng Xiaopeng Lu Qiaoyan Yang Qian Zhu Tianyun Hou Meiting Li Chaohua Liu Lina Wang Xingzhi Xu Ying Zhao Haiying Wang Yang Yang Wei-Guo Zhu 
The authors are grateful to Dr. Tanya Paull （University of Texas, USA） and Dr. Fabrizio d＇Adda di Fagagna （FIRC Institute of Molecular Oncology Foundation, Italy） for kindly providing the ATM plasmids; to Dr. Junjie Chen （MD Anderson Cancer Center, USA） for kindly providing NBSI KO HeLa cells and to Dr. Jessica Tamanini for editing the manuscript prior to submission. This study was supported by the National Key R＆D Program of China （grant number 2017YFA0503900） and the National Natural Science Foundation of China （grant numbers 81621063, 81530074, 31570812 and 81720108027）, and the Shenzhen Municipal Commission of Science and Technology Innovation （grant numbers JCYJ20160427104855100 and JCYJ201708180924S0901）.
Linker histone HI is a master regulator of higher order chromatin structure, but its involvement in the DNA damage response and repair is unclear. Here, we report that linker histone H1.2 is an essential regulator of ...
关键词：DNA damage response PolyADP-ribosylation 
An essential role for PNLDC1 in piRNA 3＇ end trimming and male fertility in mice被引量：4
《Cell Research》2017年第11期1392-1396,共5页Yue Zhang Rui Guo Yiqiang Cui Zhiping Zhu Yingwen Zhang Hao Wu Bo Zheng Qiuling Yue Shun Bai Wentao Zeng Xuejiang Guo Zuomin Zhou Bin Shen Ke Zheng Mingxi Liu Lan Ye Jiahao Sha 
This work was supported by the National Key R＆D Program of China （2016YFA0500902 and 2017YFA0103803）, the National Basic Research Program of China （2015CB943003）, National Natural Science Foundation of China Grant （81471502, 31771651, 31471228）, Excellent Youth Foundation of Jiangsu Scientific Committee（grant BK20150047）, and Innovative and Entrepreneurial Program of Jiangsu Province. We thank Jingdi Hu （Shanghai Biotechnology Corporation, Shanghai, China） for smalt RNA analysis.
Dear Editor, PIWI-interacting RNAs （piRNAs） are germ cell-specific small non-coding RNAs that are essential for silenc- ing transposable elements. Substantial efforts in the past decade have led to an understanding...
Signature motif-guided identification of receptors for peptide hormones essential for root meristem growth被引量：30
《Cell Research》2016年第6期674-685,共12页Wen Song Li Liu Jizong Wang Zhen Wu Heqiao Zhang Jiao Tang Guangzhong Lin Yichuan Wang Xing Wen Wenyang Li Zhifu Han Hongwei Guo Jijie Chai 
Acknowledgments We thank S Huang and J He at Shanghai Synchrotron Radiation Facility （SSRF） for assistance with data collection; H Deng and J Liu at the center for Biomedical Analysis of Tsinghua University for MS analysis; L Li and A Jiang at Peking University for pro- viding the incubator. We acknowledge the Tsinghua University Branch of China National Center for Protein Sciences Beijing for providing the facility support. This work was funded by Projects of International Cooperation and Exchanges of the National Natural Science Foundation of China （31420103906）, the Ministry of Science and Technology of China （2015CB910200） and State Key Program of the National Natural Science of China （31130063 and 31421001） to JC; the National Natural Science Foundation of Chi- na （91217305 and 91017010） to HG.
Peptide-mediated cell-to-cell signaling has crucial roles in coordination and definition of cellular functions in plants. Peptide-receptor matching is important for understanding the mechanisms underlying peptide-medi...
关键词：peptide hormone RAM RGF receptor crystal structure RxR motif 
RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor I in Arabidopsis thaliana被引量：32
《Cell Research》2016年第6期686-698,共13页Yang Ou Xiaoting Lu Quaner Zi Qingqing Xun Jingjie Zhang Yujun Wu Hongyong Shi Zhuoyun Wei Baolin Zhao Xiaoyue Zhang Kai He Xiaoping Gou Chuanyou Li Jia Li 
Acknowledgments We are grateful to the Arabidopsis Biological Resource Center for the T-DNA insertion lines used in these studies. We also thank Wendy Chen for reading and commenting on the manuscript and Zeping Cai for providing transgenic plant seeds carrying pSHR：：N- LS-YFP, pSCR： ：NLS-YFP, or pWOXS： ：NLS- YFP. This study was supported by the National Natural Science Foundation of China （31470380, 31530005, and 91317311 to JL）.
RGF1, a secreted peptide hormone, plays key roles in root meristem development in Arabidopsis. Previous studies indicated that a functional RGF1 needs to be sulfated at a tyrosine residue by a tyrosylprotein sulfotran...
关键词：receptor-like kinase RGF 1 RGF 1 INSENSITIVE PLETHORA ARABIDOPSIS 
Centrosomal protein FOR20 is essential for S-phase progression by recruiting Plkl to centrosomes被引量：6
《Cell Research》2013年第11期1284-1295,共12页Minhong Shen Yuqi Cai YuehongYang Xiaoyi Yan Xiaoqi Liu Tianhua Zhou 
Centrosomes are required for efficient cell cycle progression mainly by orchestrating microtubule dynamics and facilitating G1/S and G2/M transitions. However, the role of centrosomes in S-phase progression is largely...
关键词：cell cycle FOR20 Plkl S-PHASE DNA replication 
Cep57, a NEDDl-binding pericentriolar material component, is essential for spindle pole integrity被引量：2
《Cell Research》2012年第9期1390-1401,共12页Qixi Wu Runsheng He Haining Zhou Albert CH Yu Bo Zhang Junlin Teng Jianguo Chen 
We thank Chuanmao Zhang, Xiaoyan Zhang and Jingyan Fu for TPX-2 antibody and NEDD1 plasmids; Masatoshi Takeichi and Wenxiang Meng for the ct-tubulin-pCAsalGFP plasmid. This work was supported by the National Natural Science Foundation of China （30971433, 31171283） and the National Basic Research Program of China （973 Program; 2010CB833705）.
Formation of a bipolar spindle is indispensable for faithful chromosome segregation and cell division. Spindle integrity is largely dependent on the centrosome and the microtubule network. Centrosome protein Cep57 can...
关键词：Cep57 CENTROSOME SPINDLE cell cycle 
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