FRIZZLED

作品数：70被引量：296H指数：9
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相关领域：医药卫生生物学更多>>
相关作者：赵成海王进卜献民张宁庄立岩更多>>
相关机构：中国医科大学南方医科大学上海海洋大学东南大学更多>>
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相关基金：国家自然科学基金辽宁省自然科学基金云南省应用基础研究基金湖北省自然科学基金更多>>
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Cryo-EM structure of constitutively active human Frizzled 7 in complex with heterotrimeric G_(s)
《Cell Research》2021年第12期1311-1314,共4页Lu Xu Bo Chen Hannes Schihada Shane C.Wright Ainoleena Turku Yiran Wu Gye-Won Han Maria Kowalski-Jahn Pawel Kozielewicz Carl-Fredrik Bowin Xianjun Zhang Chao Li Michel Bouvier Gunnar Schulte Fei Xu 
This work was supported by the National Key R&D Program of China(2018YFA0507000 to F.X.);the National Natural Science Foundation of China(32071194 to F.X.);Work at Karolinska Institutet was supported by Karolinska Institutet,the Swedish Research Council(2017-04676;2019-01190);the Swedish Cancer Society(CAN2017/561,201102 PjF,200264P);the Novo Nordisk Foundation(NNF17OC0026940;NNF20OC0063168);The Swedish Society of Medical Research(SSMF;P19-0055);the Lars Hierta Memorial Foundation(FO2019-0086,FO2020-0304);The Alex and Eva Wallström Foundation for Scientific Research and Education(2020-00228);the German Research Foundation(DFG,427840891,KO 5463/1-1).S.C.W.is supported by a fellowship from the Swedish Society for Medical Research(P18-0098);Computational resources were provided by the Swedish National Infrastructure for Computing(SNIC 2020/5-500).M.B.is funded by the CIHR(FDN-148431);holds a Canada Research Chair in Signal Transduction and Molecular Pharmacology.
Dear Editor,The ten mammalian Frizzleds(FZD1–10)belong to the class F of G protein-coupled receptors(GPCRs)and mediate WNT signaling through interaction with transducer proteins including Dishevelled(DVL)or heterotri...
关键词：INVOLVEMENT CONSTITUTIVE FRIZZLED 
Structural basis of the Norrin-Frizzled 4 interaction被引量：3
《Cell Research》2015年第9期1078-1081,共4页Guobo Shen Jiyuan Ke Zhizhi Wang Zhihong Cheng Xin Gu Yuquan Wei Karsten Melcher H Eric Xu Wenqing Xu 
Norrin, also known as the Norrie disease protein or X-linked exudative vitreoretinopathy 2 protein, is a secreted retinal growth factor with angiogenic and neuroprotective properties. Mutations in the NPD gene, which ...
关键词：结构基础 相互作用 视网膜 保护特性 血管生成 生长因子 突变基因 蛋白质 
Wnt signaling control of bone cell apoptosis被引量：30
《Cell Research》2008年第2期248-253,共6页Bodine,PV 
Wnts are a large family of growth factors that mediate essential biological processes like embryogenesis, morpho- genesis and organogenesis. These proteins also play a role in oncogenesis, and they regulate apoptosis ...
关键词：LDL receptor-related protein secreted frizzled-related protein glycogen synthase kinase OSTEOBLAST bone formation programmed cell death 
Characterization of Function of Three Domains in Dishevelled-1: DEP Domain is Responsible for Membrane Translocation of Dishevelled-1被引量：5
《Cell Research》2004年第4期324-330,共7页WeiJunPAN ShuZhaoPANG TaoHUANG HuiYunGUO DianqingWU LinLI 
Wnt signaling plays an important role in embryogenesis and tumorgenesis. Although the mechanism about how Wnts transduce their signaling from receptor frizzled (Fz) to cytosol has not been understood, dishevelled (Dvl...
关键词：Wnt frizzled-7 DISHEVELLED DIX PDZ DEP membrane translocation signal transduction 
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