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ADAM8 inactivation modulates cellular component assembly gene expression in the mouse intervertebral disc: 《Genes & Diseases》2025年第3期54-56,共3页Ken Chen Zuozhen Tian Motomi EnomotoIwamoto Yejia Zhang; Dear Editor ADAM8(ADAM metallopeptidase domain 8,aka MS2/CD156/CD156a)is a membrane-anchored proteinase.ADAM8 and its proteolytic product,fibronectin fragments,are elevated in degenerative human intervertebral discs(I...; 关键词：degenerative human intervertebral discs ivds degenerative disc diseasea Intervertebral Disc fibronectin fragments DEGENERATION Adam Fibronectin Fragments Gene Expression

Histone methylation reprogramming underpins gene expression dynamics in Phytophthora during host infection: 《Science China(Life Sciences)》2025年第4期1190-1193,共4页Haidong Shu Guoyu Yin Meihui Wu Yujie Fang Yufeng Fang Yuanchao Wang Han Chen Suomeng Dong; supported by the National Natural Science Foundation of China(32100158 to H.C.);the National Key R&D Program of China(2022YFC2601000 and 2022YFD1100202 to S.D.);the Natural Science Foundation of Jiangsu Province(BK20200538 to H.C.);the China Agriculture Research System-potato(CARS-potato,CARS09-P20 to S.D.);the Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX19_0535 to H.S.)。; Dear Editor,Epigenetic programming plays a critical role in response to environmental fluctuations in eukaryotes(Jaenisch and Bird,2003).From initial contact to successful colonization,pathogenic microorganisms adeptl...; 关键词：environmental fluctuations adapt host environment histone methylation reprogramming PHYTOPHTHORA epigenetic programming plant pathogens gene expression dynamics adapt environmental changes

Brucea javanica Seed Oil Emulsion and Shengmai Injections Improve Peripheral Microcirculation in Treatment of Gastric Cancer: 《Chinese Journal of Integrative Medicine》2025年第4期299-310,共12页QUAN Li NIU Wen-hao YANG Fu-peng ZHANG Yan-da DING Ru HE Zhi-qing WANG Zhan-hui REN Chang-zhen LIANG Chun; Supported by the National Natural Science Foundation of China(No.82120108004)。; Objective:To explore and verify the effect and potential mechanism of Brucea javanica Seed Oil Emulsion Injection(YDZI)and Shengmai Injection(SMI)on peripheral microcirculation dysfunction in treatment of gastric canc...; 关键词：peripheral microvascular reactivity pathway analysis gene expression network pharmacology Chinese medicine β-sitesterol

Genome-Wide Analysis of Urea Transporter(ut)Gene Family in Spotted Sea Bass(Lateolabrax maculatus):Evolution and Differential Expression After Salinity Adaptation: 《Journal of Ocean University of China》2025年第2期427-438,共12页YANG Rutao HUANG Zurui LI Jinku WEN Haishen QI Xin ZHANG Kaiqiang ZHANG Jingru LIU Mengqun LI Jifang ZHANG Meizhao LI Yun; supported by the National Natural Science Foundation of China(No.32072947);the China Agriculture Research System(No.CARS-47)。; Urea is a major end product of nitrogen catabolism,serving as an osmolyte to regulate osmotic stress in fish exposed to varying water environments.It has been well known that urea transporters(UTs)facilitate the rapid...; 关键词：spotted sea bass urea transporter salinity transfer gene expression OSMOREGULATION

Decreased gene expression of interleukin 2 receptor subunitγ(CD132)in tissues of patients with Crohn’s disease: 《World Journal of Gastroenterology》2025年第12期14-26,共13页Juan Carlos Andreu-Ballester Carolina Hurtado-Marcos Carlos García-Ballesteros Jaime Pérez-Griera Fernando Izquierdo Dolores Ollero Ana Jiménez Rafael Gil-Borrás Antonio Llombart-Cussac Francisca López-Chuliá Carmen Cuéllar; A deficiency ofγδT cells has been described in Crohn's disease(CD).AIM To analyze the gene expression of interleukin 7(IL-7)and its receptors in the tissues of patients with CD.METHODS We studied the peripheral bloo...; 关键词：Crohn’s disease Interleukin 7 Interleukin 2 receptor subunitγ(CD 132) Caspase-3 γδT cells

The role of the MAGE family:molecular expression,oncogenic roles,and prospects for immunotherapy in cancer: 《Life Research》2025年第1期16-31,共16页Yu-Ting Niu Ya-Tong Bi Li Zhu; supported by Startup Fund for Young Faculty at SJTU(SFYF at SJTU)(No.24X010500176).; As a member of the Cancer-Testis Antigens,the Melanoma-associated antigen(MAGE)family is typically expressed in normal tissues such as the testis.However,in various types of tumor cells,their expression is abnormally ...; 关键词：Cancer-Testis Antigens MAGE family gene expression tumor biology IMMUNOTHERAPY

Dissecting Spatiotemporal Structures in Spatial Transcriptomics via Diffusion-Based Adversarial Learning: 《Research》2025年第1期292-307,共16页Haiyun Wang Jianping Zhao Qing Nie Chunhou Zheng Xiaoqiang Sun; supported by grants from the National Key R&D Program of China(2021YFF1200903);the National Natural Science Foundation of China(62273364,11931019,11871070,and 62362062);the Guangdong Basic and Applied Basic Research Foundation(2020B1515020047);Fundamental Research Funds for the Central Universities,Sun Yat-sen University(231lgbj025);the open fund of Information Materials and Intelligent Sensing Laboratory of Anhui Province(grant no.IMIS202105).; Recent advancements in spatial transcriptomics(ST)technologies offer unprecedented opportunities to unveil the spatial heterogeneity of gene expression and cell states within tissues.Despite these capabilities of the ...; 关键词：adversarial graph autoencoder spatial transcriptomics st technologies cell states spatiotemporal structures computational frameworkpearlst partial gene expression spatial transcriptomics accurate infe

Genetic and epigenetic alterations associated with gestational diabetes mellitus and adverse neonatal outcomes: 《World Journal of Clinical Pediatrics》2025年第1期6-20,共15页Amreen Shamsad Tanu Gautam Renu Singh Monisha Banerjee; Supported by Maulana Azad National Fellowship,University Grants Commission,New Delhi,and Department of Biotechnology,New Delhi,No.AS[82-27/2019(SA III)];DBT-BUILDER-University of Lucknow Interdisciplinary Life Science Programme for Advance Research and Education(Level II),No.TG(BT/INF/22/SP47623/2022).; Gestational diabetes mellitus(GDM)is a metabolic disorder,recognised during 24-28 weeks of pregnancy.GDM is linked with adverse newborn outcomes such as macrosomia,premature delivery,metabolic disorder,cardiovascular,...; 关键词：Gene expression Gestational diabetes mellitus Feto-maternal outcome Epigenetic alteration Molecular biomarkers

Gene Expression Data Analysis Based on Mixed Effects Model: 《Journal of Computer and Communications》2025年第2期223-235,共13页Yuanbo Dai; DNA microarray technology is an extremely effective technique for studying gene expression patterns in cells, and the main challenge currently faced by this technology is how to analyze the large amount of gene expres...; 关键词：Mixed Effects Model Gene Expression Data Analysis Gene Analysis Gene Chip

Effects of glyphosate,antibiotics,and an anticoccidial drug on pancreatic gene expression and blood physiology in broilers: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2025年第2期185-199,共15页Georgi Yu.LAPTEV Daria G.TIURINA Elena A.YILDIRIM Elena P.GORFUNKEL Larisa A.ILINA Valentina A.FILIPPOVA Andrei V.DUBROVIN Alisa S.DUBROVINA Evgeni A.BRAZHNIK Natalia I.NOVIKOVA Veronika K.MELIKIDI Kseniya A.SOKOLOVA Ekaterina S.PONOMAREVA Vasiliy A.ZAIKIN Darren K.GRIFFIN Michael N.ROMANOV; supported by the Russian Science Foundation(No.22-16-00128),“Investigation of the Toxic Effect of Glyphosates on the Functional State of the Bird Intestinal Microbial Community,Their Growth and Development,and the Development of a Biological Product Based on the Glyphosate Degrading Strain”.; Drugs and pesticide residues in broiler feed can compromise the therapeutic and production benefits of antibiotic(ANT)application and affect gene expression.In this study,we analyzed the expression of 13 key pancreati...; 关键词：GLYPHOSATE Antibiotic Anticoccidial drug PANCREAS BROILER Gene expression Blood parameter

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