GENE_SILENCING

作品数：162被引量：627H指数：11
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Silencing hepatitis B virus covalently closed circular DNA: The potential of an epigenetic therapy approach被引量：4
《World Journal of Gastroenterology》2021年第23期3182-3207,共26页Prashika Singh Dylan Kairuz Patrick Arbuthnot Kristie Bloom 
Global prophylactic vaccination programmes have helped to curb new hepatitis B virus(HBV)infections.However,it is estimated that nearly 300 million people are chronically infected and have a high risk of developing he...
关键词：Chronic hepatitis B virus Epigenetic gene silencing Functional cure Hepatocellular carcinoma Hepatitis B surface antigen 
Toward a new era of hepatitis B virus therapeutics:The pursuit of a functional cure被引量：12
《World Journal of Gastroenterology》2021年第21期2727-2757,共31页Efthymios P Tsounis Evanthia Tourkochristou Athanasia Mouzaki Christos Triantos 
Hepatitis B virus(HBV)infection,although preventable by vaccination,remains a global health problem and a major cause of chronic liver disease.Although current treatment strategies suppress viral replication very effi...
关键词：Chronic hepatitis B Functional cure Direct-acting antivirals Gene silencing Immunotherapy Therapeutic vaccination 
Piwi like RNA-mediated gene silencing 1 gene as a possible major player in gastric cancer被引量：1
《World Journal of Gastroenterology》2018年第47期5338-5350,共13页Taíssa Araújo Andre Khayat Luciana Quintana Danielle Calcagno Ronald Mourao Antonio Modesto Juliana Paiva Adhara Lima Fabiano Moreira Edivaldo Oliveira Michel Souza Moneeb Othman Thomas Liehr Eliana Abdelhay Renata Gomes Sidney Santos Paulo Assumpcao 
Supported by Fundacao Amazonia de Amparo a Estudos e Pesquisa(FAPESPA),No.174/2014
AIM To establish a permanent piwi like RNA-mediated genesilencing 1(PIWIL1) gene knockout in AGP01 gastric cancer cell line using CRISPR-Cas9 system and analyze phenotypic modifications as well as gene expression alte...
关键词：Gastric cancer Piwi like RNA-mediated gene silencing 1 CRISPR-Cas9 Migration INVASION 
Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C被引量：1
《World Journal of Gastroenterology》2016年第45期9954-9965,共12页Esperance AK Schaefer James Meixiong Christina Mark Amy Deik Daniel L Motola Dahlene Fusco Andrew Yang Cynthia Brisac Shadi Salloum Wenyu Lin Clary B Clish Lee F Peng Raymond T Chung 
Supported by the United States National Institutes of Health(NIH),No.F32-DK097855(to Schaefer EAK),No.T32-DK008191(to Motola DL),No.K08-DK088951(to Peng LF),and No.K24-DK078772(to Chung RT)
AIM To characterize the role of apolipoprotein B100(apoB 100) in hepatitis C viral(HCV) infection. METHODS In this study, we utilize a gene editing tool, transcription activator-like effector nucleases(TALENs), to gen...
关键词：APOLIPOPROTEIN LIPID Hepatitis C virus Gene silencing Viral replication 
Methylation-mediated gene silencing as biomarkers of gastric cancer:a review被引量：8
《World Journal of Gastroenterology》2014年第34期11991-12006,共16页Jun Nakamura Tomokazu Tanaka Yoshihiko Kitajima Hirokazu Noshiro Kohji Miyazaki 
Despite a decline in the overall incidence of gastric cancer(GC),the disease remains the second most common cause of cancer-related death worldwide and is thus a significant global health problem.The best means of imp...
关键词：Gastric cancer METHYLATION BIOMARKER Early detection Drug sensitivity 
Re-expression of methylation-induced tumor suppressor gene silencing is associated with the state of histone modification in gastric cancer cell lines被引量：27
《World Journal of Gastroenterology》2007年第46期6166-6171,共6页Chun-Feng Meng Xin-Jiang Zhu Guo Peng Dong-Qiu Dai 
National Natural Science Foundation of China,No.30271477,No.30572162
AIM： To identify the relationship between DNA hyper- methylation and histone modification at a hyperme- thylated, silenced tumor suppressor gene promoter in human gastric cancer cell lines and to elucidate whether al...
关键词：Gastric cancer DNA hypermethylation Histone methylation Histone acetylation p16 mutLhomolog 1 5-Aza-2＇-deoxycytidine  Trichostatin A 
ShRNA-mediated gene silencing of β-catenin inhibits growth of human colon cancer cells被引量：34
《World Journal of Gastroenterology》2007年第48期6581-6587,共7页Wen-Sheng Huang Jian-Ping Wang Ting Wang Jie-Yu Fang Ping Lan Jin-Ping Ma 
Supported by the Guangdong Provincial Scientific Research Grants: No. 2004B30301002, No. 2007B030702012 and No. 04300330
AIM: To observe the gene silencing mediated by the specific shRNA targeted against β-catenin and its effect on cell proliferation and cycle distribution in the human colon cancer cell line Colo205. METHODS: Two shRNA...
关键词：Β-CATENIN RNA interference Apoptosis Colon cancer WNT 
RNA interference-mediated gene silencing of vascular endothelial growth factor in colon cancer cells被引量：5
《World Journal of Gastroenterology》2007年第40期5312-5316,共5页Tie-Jun Li Jian-Ning Song Kai Kang Shu-Sheng Tong Zan-Lan Hu Tong-Chuan He Bing-Qiang Zhang Cai-Quan Zhang 
Supported in part by research grants from the National Natural Science Foundation of China,No.30300298;the National Natural Science Foundation of China's Joint Research Fund for Overseas Chinese Young Scholars,No.30228026
AIM： TO inhibit the expression of vascular endothelial growth factor （VEGF） in colon cancer cell line by RNA interference （RNAi）.METHODS： Followed the service of E-RNAi, we designed and constructed two kinds of ...
关键词：RNA interference Vascular endothelialgrowth factor Colon cancer Northern blotting Western blotting 
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