GENE_THERAPY

作品数：701被引量：2236H指数：20
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Lentivirus carrying the Atoh1 gene infects normal rat cochlea被引量：6
《Neural Regeneration Research》2013年第17期1551-1559,共9页Song Pan Jingzhi Wan Shaosheng Liu Song Zhang Hao Xiong Jun Zhou Wu Xiong Kunfei Yu Yong Fu 
supported by grants from the National Basic Research Program of China (973 Program), No. 2012CB967900, 2012CB967904;the National Natural Science Foundation of China, No. 81070782;the Natural Science Foundation of Zhejiang Province, China, No. 30672308;the Qianjiang Talent Project of Science and Technology Ministry in Zhejiang Province, No. 2011R10014;the Natural Science Foundation of Ningbo, No. 2011A610042
Lentivirus carrying the Atohl gene can infect Corti＇s organ and express a hair-like cell surface marker in the supporting cell area. However, expression of the gene carried by adenovirus is instantaneous, which undou...
关键词：neural regeneration gene therapy Atohl LENTIVIRUS hair cells myosin 7a COCHLEA auditorythreshold grants-supported paper NEUROREGENERATION 
TALEN or Cas9-Rapid,Efficient and Specific Choices for Genome Modifications被引量：53
《Journal of Genetics and Genomics》2013年第6期281-289,共9页Chuanxian Wei Jiyong Liu Zhongsheng Yu Bo Zhang Guanjun Gao Renjie Jiao 
supported financially by the National Basic Research Program of China(973 Program)(Nos. 2009CB918702 and 2012CB825504);the National Natural Science Foundation of China(Nos.31201007,31271573 and 31071087)
Precise modifications of complex genomes at the single nucleotide level have been one of the big goals for scientists working in basic and applied genetics,including biotechnology,drug development,gene therapy and syn...
关键词：Genome editing TALEN CRISPR/Cas9 Gene therapy Stem cells 
Influence of β-catenin Small Interfering RNA on Human Osteosarcoma Cells
《Journal of Huazhong University of Science and Technology(Medical Sciences)》2011年第3期353-358,共6页张帆 陈安民 陈剑锋 余天 郭风劲 
supported by a grant from the Major State Basic Research Development Program of China (973 Program) (No. 2002CB513100)
This study examined the effect of small interfering RNA-mediated β-catenin knockdown on the survival,invasion and chemosensitivity of human osteosarcoma cells（U2-OS cells）.The siRNA against β-catenin was construct...
关键词：Β-CATENIN OSTEOSARCOMA SIRNA gene therapy 
WHAT CAN WE LEARN FROM VIRUS IN DESIGNING NONVIRAL GENE VECTORS
《Chinese Journal of Polymer Science》2011年第3期274-287,共14页申有青 
supported by the Distinguished Young Scholars(No.50888001);National Natural Science Foundation of China(No.21090352);National Basic Research Program(973 Program,2009CB526403);Program for Changjiang Scholars and Innovative Research Team in University of China and Fundamental Research Funds for Central Universities(No.2010QNA4022)
Gene therapy has emerged as a potential new approach to treat genetic disorders by delivering therapeutic genes to target diseased tissues. However, its clinical use has been impeded by gene delivery systems. The vira...
关键词：Gene therapy Gene delivery VIRUS Nonviral vectors Cationic polymers. 
p53-expressing conditionally replicative adenovirus CNHK500-p53 against hepatocellular carcinoma in vitro被引量：4
《World Journal of Gastroenterology》2007年第5期683-691,共9页Hong-Chuan Zhao Qi Zhang Yang Yang Min-Qiang Lu Hua Li Chi Xu Gui-Hua Chen 
Supported by the Major State Basic Research Development Program (973 Program) of China, No. 2003CB515507
AIM： To develop a conditionally replicative gene-viral vector system called CNHK500-p53, which contains dual promoters within the E1 region, and combines the advantages of oncolytic virus and gene therapies for hepat...
关键词：Conditionally replicative adenovirus Oncolytic virotherapy Gene therapy p53 gene Hepatocellular carcinoma 
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