National Key R&D Program of China:Research on the Functional Characteristics of"Special Effects"and"Common Effects"of Acupoints(No.2019YFC1709001);the National Natural Science Foundation of China:Study on the Immune Mechanisms of Macrophage M1/M2 Polarization in the Treatment of Rheumatoid Arthritis by Moxibustion"Strengthening Body Resistance and Eliminating Evil"(No.81973959);Research on"ImmuneInflammation"Molecular Signal Regulation of NLRP3 Inflammasomes in RA with Moxibustion Treatment(No.81774435);Foundation of Sichuan Provincial Administration of Traditional Chinese Medicine:Research on the Mechanism of MIF-GC Rhythm in the Anti-inflammatory Effect of Moxibustion in Treating Rheumatoid Arthritis(No.2018JC007);Science and Technology Innovation Seedling Project of Sichuan Province,China:based on Macrophage M1 Polarization Signaling Pathway TLR4-MyD88-NF-κB and Its Regulatory Molecule TIM-3 Exploring the Effect Mechanism of Moxibustion on Experimental RA Model(No.2022037);Chengdu University of Traditional Chinese Medicine Foundation:Study on the Mechanism of"MIF-target Protein-GC-inflammation"in the AntiInflammatory Effect of Moxibustion in the Treatment of RA(No.QNXZ2018034)。
OBJECTIVE:To test the hypothesis that moxibustion may inhibit rheumatoid arthritis(RA)synovial inflammation by regulating the expression of macrophage migration inhibitory factor(MIF)/glucocorticoids(GCs).METHODS:Fift...
Supported by the“Double-First Class”project of Beijing(No.1000041510155)。
OBJECTIVE:To verify the efficacy of glucocorticoids,chloroquine and vitamin A in the treatment of cytokine release syndrome(CRS),and to investigate the underlying mechanisms,based on network pharmacology.METHODS:We us...
Supported by Projects in the National Science & Technology Pillar Program in the Eleventh Five-year Plan Period (No. 2006BA104A10);State Traditional Chinese Medicine Department Research Foundation (No. 200707016);National Natural Science Foundation of China (No. 81072764)
Glucocorticoid(GC) plays an important role in anti-inflammatory,anti-allergic effects and immunosuppression,and has become a widely used drug in clinical departments.However,GC also produces a number of serious side e...
Case HistoryPatient Chen, female, 68 years, case number: 9800297; date of hospitalization: May 11, 1998.Chief complaints: Fever accompanied with cough and lassitude for 3 months and skin rash for 7 days.History of pre...
In recent years, with the establishment of the theory of air passage inflammation concerning the pathologic mechanism of asthma, the glucocorticoid hormone (referred to hereafter only as hormone for short), a strong i...