HEPATOCARCINOMA

作品数：171被引量：811H指数：15
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相关领域：医药卫生生物学更多>>
相关作者：崔景荣李润涛郭维于世英王亚萍更多>>
相关机构：北京大学南开大学华中科技大学华中科技大学同济医学院附属普爱医院更多>>
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相关基金：国家自然科学基金国家高技术研究发展计划广东省自然科学基金中国博士后科学基金更多>>
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Use of traditional Chinese medicine bezoars and bezoar-containing preparations in hepatocarcinoma
《World Journal of Gastrointestinal Oncology》2024年第12期4770-4777,共8页De-Hui Li Qian-Er Wen Rui-Qi Feng Chang Qiao Xiao-Tong Tian 
Supported by 2023 Government-funded Project of The Outstanding Talents Training Program in Clinical Medicine,No.ZF2023165;Key Research and Development Projects of Hebei Province,No.18277731D;and Natural Science Foundation of Hebei Province,No.H202423105.
This manuscript used network pharmacology and experimental verification to analyze the anti-hepatocarcinoma mechanism of action of bezoars in traditional Chinese medicine(TCM),discovering that it can affect the immune...
关键词：BEZOAR Traditional Chinese medicine Liver cancer Immune microenvironment Network pharmacology 
Abnormally activated wingless/integrated signaling modulates tumor-associated macrophage polarization and potentially promotes hepatocarcinoma cell growth
《World Journal of Gastroenterology》2024年第41期4490-4495,共6页Wei-Lu Wang Paul Kwong Hang Tam Yan Chen 
Supported by Macao Science and Technology Development Fund,No.0086/2022/A and No.0097/2022/A2.
In this article,we comment on the article by Huang et al.The urgent development of new therapeutic strategies targeting macrophage polarization is critical in the fight against liver cancer.Tumor-associated macrophage...
关键词：Liver cancer Hepatocarcinoma cell Wingless/integrated signaling pathway M2 tumor-associated macrophages Polarization 
Rapid discovery of a novel “green” and natural GST inhibitor for sensitizing hepatocellular carcinoma to Cisplatin by visual screening strategy
《Journal of Pharmaceutical Analysis》2024年第5期693-706,共14页Linxi Mao Yan Qin Jialong Fan Wei Yang Bin Li Liang Cao Liqin Yuan Mengyun Wang Bin Liu Wei Wang 
supported by the National Natural Science Foundation of China(Grant Nos.:82003931,82204766 and 81374062);the Outstanding Youth Foundation of Hunan Provincial Education Department of China(Grant No.:20B445);the Hunan Youth Science and Technology Innovation Talents Project,China(Grant No.:2021RC3100);the Chinese Postdoctoral Science foundation(Grant No.:2021M690974);Changjiang Scholars Program in Ministry Education,People's Republic of China(Program No.:T2019133);the Scientific Research Project of Hunan Provincial Education Department(Project No.:21B0394).
Over-expression of glutathione S-transferase(GST)can promote Cisplatin resistance in hepatocellular carcinoma(HCC)treatment.Hence,inhibiting GST is an attractive strategy to improve Cisplatin sensitivity in HCC therap...
关键词：GST Drug resistance Fluorescence HEPATOCARCINOMA Natural compound C1 “Green”GST inhibitor 
Efficacy and safety of targeted therapy plus immunotherapy combined with hepatic artery infusion chemotherapy (FOLFOX) for unresectable hepatocarcinoma
《World Journal of Gastroenterology》2024年第17期2321-2331,共11页Zhi-Peng Lin Xiao-Long Hu Du Chen Da-Bei Huang Xu-Gong Zou Hai Zhong Sheng-Xiang Xu Yuan Chen Xiao-Qun Li Jian Zhang 
This study was reviewed and approved by the Ethics Committee of Zhongshan People’s Hospital(Approval No.2022-029).
BACKGROUND The advent of cutting-edge systemic therapies has driven advances in the treatment of hepatocellular carcinoma(HCC),and therapeutic strategies with multiple modes of delivery have been shown to be more effi...
关键词：Hepatocellular carcinoma Hepatic arterial infusion chemotherapy Targeted therapy IMMUNOTHERAPY Adverse events 
Post-trans-arterial chemoembolization hepatic necrosis and biliary stenosis: Clinical charateristics and endoscopic approach被引量：1
《World Journal of Clinical Cases》2023年第36期8434-8439,共6页Silvia Cocca Lorenzo Carloni Margherita Marocchi Giuseppe Grande Marcello Bianchini Antonio Colecchia Rita Conigliaro Helga Bertani 
Liver cancer is the fifth most common tumor and the second highest death-related cancer in the world.Hepatocarcinoma(HCC)represents 90%of liver cancers.According to the Barcelona Clinic Liver Cancer group,different tr...
关键词：HEPATOCARCINOMA Trans-arterial Chemoembolization Biliary stenosis Multistenting 
Cocktail hepatocarcinoma therapy by a super-assembled nano-pill targeting XPO1 and ATR synergistically
《Journal of Pharmaceutical Analysis》2023年第6期603-615,共13页Liuyun Gong Yinliang Lu Jing Wang Xinyue Li Jing Zhao Yuetong Chen Rongze Ma Jinlu Ma Tianya Liu Suxia Han 
supported by the National Natural Science Foundation of China(Grant Nos.:81272488 and 81602802);the Shaanxi Province Innovation Capacity Support Program(Grant No.:2018TD-002).
Intensive cancer treatment with drug combination is widely exploited in the clinic but suffers from inconsistent pharmacokinetics among different therapeutic agents.To overcome it,the emerging nanomedicine offers an u...
关键词：Liver cancer Drug combination Cancer therapy ATR inhibitor XPO1 inhibitor 
Network pharmacology and preliminary cell screening studies on the anti-liver cancer activity of Nauclea Officinalis
《Journal of Hainan Medical University》2023年第12期1-9,共9页CHEN Wei-jia ZHOU Ming-yan HU Ji-cheng ZHU Ze XU Jian 
Major Science and Technology Project of Hainan Province(No.ZDKJ2019009);Construction Project of Clinical Medical Center in Hainan Province。
Objective:To explore the mechanism of Nauclea Officinalis of anti-liver cancer effect based on network pharmacology,and to preliminarily verify anti-liver cancer activity of Nauclea Officinalis through cell screening....
关键词：Nauclea Officinalis HEPATOCARCINOMA Network pharmacology Mechanism of action In vitro cell assay 
The tumor microenvironment in hepatocarcinoma:dissecting the functions of cancer-associated fibroblasts
《Hepatoma Research》2023年第1期52-69,共18页Massimiliano Cadamuro Giorgia Nuozzi Paolo Simioni Luca Fabris 
Hepatocellular carcinoma(HCC)is the most common primary liver malignancy,deriving from the neoplastic transformation of hepatocytes,most often forced to long-lasting regeneration by the cirrhotic background.HCC is an ...
关键词：Cancer-associated fibroblasts tumor immune microenvironment CAF heterogeneity extracellular matrix remodeling tumor-associated macrophages 
Two novel compounds, ergosterol and ergosta-5,8-dien-3-ol, from Termitomyces heimii Natarajan demonstrate promising antihepatocarcinoma activity被引量：1
《Journal of Traditional Chinese Medical Sciences》2022年第4期443-453,共11页Ribhu Ray Saparja Saha Santanu Paul 
WB-DSTBT (West Bengal Department of Science and Technology and Biotechnology,Sanction No.:1158(Sanc)/ST BT-13015/15/2021-ST SEC dated 15/02/2022) for funding the project;CSIR (Council of Scientific and Industrial Research);UGC (University Grants Commission) for providing fellowship and contingency to individual research scholars;the UGC-UPE and UGC-CAS programs at the Department of Botany,University of Calcutta for providing financial support
Background:Mushroom-derived components have immense potential to become a safe alternative in identifying lead anti-cancer molecules.Termitomyces heimii Natarajan(T.heimii)is a traditionally used edible mushroom with ...
关键词：Termitomyces heimii Natarajan ERGOSTEROL In silico docking HEPATOCARCINOMA 
All-trans retinoic acid inhibits the malignant behaviors of hepatocarcinoma cells by regulating ferroptosis被引量：3
《Genes & Diseases》2022年第6期1742-1756,共15页Yanting Sun Yun He Jishuang Tong Daijiang Liu Haodong Zhang Tongchuan He Yang Bi 
This work was supported by a research grant from the Chongqing Science and Technology Commission(No.cstc2021jcyj-msxmX0225 to YB);a research program of Chongqing Municipal Education Commission(No.KJQN201900442 to YB).
All-trans retinoic acid(ATRA)can reverse the malignant behaviors of hepatocellular carcinoma(HCC)cells,thereby exerting anti-HCC effect;however,the underlying mechanism is yet to be understood.This study aimed to demo...
关键词：All-trans retinoic acid Ferroptosis HEPATOCARCINOMA INVASION Migration 
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