HSC

作品数：547被引量：1529H指数：17
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相关领域：医药卫生更多>>
相关作者：李定国刘成海李俊陈永平贾继东更多>>
相关机构：安徽医科大学上海中医药大学广州中医药大学华中科技大学更多>>
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相关基金：国家自然科学基金广东省自然科学基金国家重点基础研究发展计划河北省自然科学基金更多>>
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Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics被引量：9
《Cell Research》2022年第1期38-53,共16页Suwei Gao Qiang Shi Yifan Zhang Guixian Liang Zhixin Kang Baofeng Huang Dongyuan Ma Lu Wang Jianwei Jiao Xiangdong Fang Cheng-Ran Xu Longqi Liu Xun Xu Berthold Gottgens Cheng Li Feng Liu 
supported by grants from the National Key R&D Program of China(2018YFA0800200,2018YFA0801000,2016YFA0100500 to F.L.,and 2016YFA0100103 to C.L.);the Strategic Priority Research Program of the Chinese Academy of Sciences,China(XDA16010207 to F.L.);the National Natural Science Foundation of China(31830061,81530004,31425016 to F.L.,and 31871266 to C.L.);NSFC Key Research Grant 71532001(to C.L.).
Limited knowledge of cellular and molecular mechanisms underlying hematopoietic stem cell and multipotent progenitor(HSC/MPP)expansion within their native niche has impeded the application of stem cell-based therapies...
关键词：FETAL EXPANSION HSC 
Suppression of m6A reader Ythdf2 promotes hematopoietic stem cell expansion被引量：25
《Cell Research》2018年第9期904-917,共14页Zhenrui Li Pengxu Qian Wanqing Shao Hailing Shi Xi C. He Madelaine Gogol Zulin Yu Yongfu Wang Meijie Qi Yunfei Zhu John M. Perry Kai Zhang Fang Tao Kun Zhou Deqing Hu Yingli Han Chongbei Zhao Richard Alexander Hanzhang Xu Shiyuan Chen Allison Peak Kathyrn Hall Michael Peterson Anoja Perera Jeffrey S. Haug Tari Parmely Hua Li Bin Shen Julia Zeitlinger Chuan He Linheng Li 
Transplantation of hematopoietic stem cells （HSCs） from human umbilical cord blood （hUCB） holds great promise for treating a broad spectrum of hematological disorders including cancer. However, the limited number ...
关键词：成年干细胞 造血 读者 VIVO mRNA HSC 稳定性 单个分子 
m6A reader suppression bolsters HSC expansion被引量：1
《Cell Research》2018年第9期875-876,共2页Xinxin Huang Hal E. Broxmeyer 
The functional importance of N6-methyladenosine （m6A） modification in human health and disease has recently entered the research spotlight. In a recent paper published in Cell Research, Li et al. report a remarkable...
关键词：HSC 读者 化学修正 RNA 核苷酸组成 聚光灯 阅读器 干细胞 
Dissecting the bone marrow HSC niches
《Cell Research》2016年第9期975-976,共2页Meng Zhao Linheng Li 
Hematopoietic stem cells （HSCs） sponsoring hematopoiesis arc preserved in the bone marrow （BM） microenvironment or niche. Here, Itkin et al. demonstrate how distinct blood vessels contribute to HSC maintenance and...
Niche-less maintenance of HSCs by 2i
《Cell Research》2013年第4期458-459,共2页ShigeoMasuda  MoLi Juan CarlosIzpisua Belmonte 
Maintenance of hematopoietic stem cells （HSCs） in vitro has been believed to be difficult due to a lack of complete understanding of HSC quiescence maintained by the niche. Recent evidence suggests that in vitro mai...
关键词：造血干细胞 少维护 饲养层细胞 细胞因子 MTOR HSC 体外 小鼠 
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