Background:immune checkpoint inhibitors(ICIs)have revolutionized the treatment of metastatic urothelial carcinoma(mUC),significantly improving survival outcomes.However,a subset of patients do not respond to ICIs,prom...
funded by the China National Science Foundation(Nos.82022048 and 82373121);the Science and Technology Planning Project of Guangzhou(No.202206080013);the National Key Research&Development Programme(No.2022YFC2505100).
To the Editor:Immunotherapy has overtaken chemotherapy(Chemo)as the frontline mode of treatment for advanced non-small cell lung cancer(NSCLC).The efficacy of immunotherapies such as immune checkpoint inhibitors(ICIs)...
supported in part by National Institutes of Health(NIH)R01 NS127824(PC),NIH R01 NS124594(PC),NIH P01 CA245705(JDL),R35 NS127083(JDL);the Department of Defense(DoD)Career Development Award W81XWH-21-1-0380(P.C.),as well as the Lerner Research Institute and Case Comprehensive Cancer Center.
Glioblastoma(GBM)is an aggressive and lethal type of brain tumor in human adults.The standard of care offers minimal clinical benefit,and most GBM patients experience tumor recurrence after treatment.In recent years,s...
funded by grants from the National Natural Science Foundation of China(Grant Nos.82003288,U20A20375,82372779,and 82103001);Tianjin Key Medical Discipline(Specialty)Construction Project(Grant No.TJYXZDXK-009A).
Objective:The combination of epithelial growth factor receptor tyrosine kinase inhibitors(EGFR-TKIs)and immune checkpoint inhibitors(ICIs)leads to an increased incidence of severe immune-related adverse events(irAEs)....