This work was supported by the National Natural Science Foundation of China(81788101,31570871,31770970);CAMS Innovation Fund for Medical Sciences(2016-12M-1-003);the National Key Basic Research Program of China(2015CB964403).
Epigenetic modification,including histone modification,precisely controls target gene expression.The posttranscriptional regulation of the innate signaling-triggered production of inflammatory cytokines and type I int...
supported by the National Basic Research Program of China (Grant No. 2012CB518904)
Influenza A virus NS1 protein has developed two main IFN-antagonizing mechanisms by inhibiting retinoic-acid-inducible gene I (RIG-I) signal transduction, or by suppressing cellular pre-mRNA processing through binding...
This work was supported by the grants from the National Natural Science Foundation of China (30623003 and 81172449); National Basic Research Program of China (973 Program) (2010CB529901 and 2011CB510104);Important National Science & Technology Specific Project of Hepatitis and Hepatoma Related Program (2008ZX10002- 023); New Innovation Program (2009-ZX-09102-246);and Zhejiang Sci-Tech University grant (1016834-Y).
Interferon-β (IFN-β) has been widely used in cancer therapy, but the clinical trial results are generally disappointing. Our previous studies have shown that an oncolytic adenovirus carrying IFN-β (ZD55-IFN-β)...
supported by grants from the 973 Program of China(No.2006CB504301).
Viral RNAs produced during viral infection are recognized by the cytoplasmic RNA helicases retinoic acid-inducible gene-I(RIG-I)and melanoma differentiation-associated gene 5(MDA5).A central adapter protein downstream...