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IRNA: 作品数：155被引量：176H指数：6; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：张方信袁爱力赵雪俭刘艳波邓芝云更多>>; 相关机构：阿尔尼拉姆医药品有限公司吉林大学第四军医大学中国医科大学更多>>; 相关期刊：更多>>; 相关基金：国家自然科学基金国际科技合作与交流专项项目河南省杰出人才创新基金广东省自然科学基金更多>>

核酸农药纳米递送系统研究进展被引量：2: 《农药学学报》2023年第6期1179-1197,1369,共20页何承帅张辉吴顺凡高云昊高聪芬; 国家重点研发计划项目“重要病虫害抗药性机制与治理技术研发”(2022YFD1400900)。; 随着现代社会的发展,人们对健康和环保的关注度逐渐提高,开发绿色环保的新型农药是未来农药领域发展的总体趋势。与传统化学农药相比,核酸农药具备靶向性强、环境兼容性好、开发简便等诸多优势,在有害生物可持续治理方面具有巨大的应用...; 关键词：核酸农药 dsRNA/siRNA 纳米材料递送系统

A candidate protective factor in amyotrophic lateral sclerosis:heterogenous nuclear ribonucleoprotein G被引量：2: 《Neural Regeneration Research》2023年第7期1527-1534,共8页Fang Yang Wen-Zhi Chen Shi-Shi Jiang Xiao-Hua Wang Ren-Shi Xu; supported by the National Natural Science Foundation of China,Nos.30560042,81160161,81360198,82160255;Education Department of Jiangxi Province,Nos.GJJ13198 and GJJ170021;Jiangxi Provincial Department of Science and Technology,Nos.[2014]-47,20142BBG70062,20171BAB215022,20192BAB205043;Health and Family Planning Commission of Jiangxi Province,No.20181019(all to RSX).; Heterogenous nuclear ribonucleoprotein G is down-regulated in the spinal cord of the Tg(SOD1*G93A)1Gur(TG)amyotrophic lateral sclerosis mouse model.However,most studies have only examined heterogenous nuclear ribonucl...; 关键词：amyotrophic lateral sclerosis Bax heterogenous nuclear ribonucleoprotein G heterogenous nuclear ribonucleoprotein G-siRNA neuron death superoxide dismutase 1 TAR DNA binding protein 43 TG(SOD1*G93A)1Gur mice

Responses Taken by Silencing of NFkappaB, STAMP1 and STAMP2 Genes and Expression of NFkB, Act-1, p53 and p73 at -/+ TNFalpha Induced LNCaP Cells: 《Journal of Cancer Therapy》2022年第12期685-700,共16页Ceren Gönen; Prostate cancer is the most commonly diagnosed cancer and the second leading cause of cancer mortality in men in the Western World. The effects of androgens are mediated by the Androgen Receptor (AR). Therefore, studi...; 关键词：Promoter Analysis RNA/siRNA Regulation of Gene Expression

Deep-piRNA:Bi-Layered Prediction Model for PIWI-Interacting RNA Using Discriminative Features: 《Computers, Materials & Continua》2022年第8期2243-2258,共16页Salman Khan Mukhtaj Khan Nadeem Iqbal Mohd Amiruddin Abd Rahman Muhammad Khalis Abdul Karim; This research was supported by the Ministry of Higher Education(MOHE)of Malaysia through Fundamental Research Grant Scheme(FRGS/1/2020/ICT02/UPM/02/3).; Piwi-interacting Ribonucleic acids(piRNAs)molecule is a wellknown subclass of small non-codingRNAmolecules that are mainly responsible for maintaining genome integrity,regulating gene expression,and germline stem cell...; 关键词：Deep neural network DNC TNC CKSNAP PseDPC cancer discovery Piwi-interacting RNAs Deep-piRNA

夏枯草三萜类提取物联合Survivin-siRNA对食管癌Eca-109细胞抑制作用研究被引量：5: 《中国当代医药》2022年第20期5-9,共5页郑学芝徐秋玲郭冉孙健王文婷; 黑龙江省省属高等学校基本科研业务费科研项目(2018-KYYWFMY-0033)。; 目的观察Survivin-siRNA能否增强夏枯草三萜类提取物对食管癌Eca-109细胞的增殖抑制、凋亡诱导作用,并探讨机制。方法将食管癌Eca-109细胞分为空白对照组、阴性对照组、夏枯草单独处理组、siRNA转染单独处理组,夏枯草+siRNA转染联合作...; 关键词：SURVIVIN siRNA 食管癌夏枯草

Erratum to: Inhibition of chemotherapy-related breast tumor EMT by application of redox-sensitive siRNA delivery system CSO-ss-SA/siRNA along with doxorubicin treatment: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2022年第2期171-172,共2页Xuan LIU Xueqing ZHOU Xuwei SHANG Li WANG Yi LI Hong YUAN Fuqiang HU; The original version of this article(Liu et al.,2020)unfortunately contained some mistakes.1.Figs.7c and 7d in p.229 were incorrect.The upper left and bottom left pictures in Fig.7c were accidentally duplicated with t...; 关键词：TREATMENT picture

壳聚糖及其衍生物递送miRNA/siRNA的研究进展被引量：2: 《化学通报》2022年第2期186-191,共6页孙玥丁威豪黎白钰王晓强; 兰州交通大学天佑创新团队项目(TY202004);兰州交通大学-天津大学联合创新基金项目(2021059)资助。; 微小RNA(microRNA,miRNA)和短链干扰RNA(small interfering RNA,siRNA)是两类具有调节基因表达功能的内源性非编码性小RNA分子。它们已成为多种疾病的潜在治疗药物,逐渐被应用于基因治疗中,而将小RNA应用于基因治疗亟需一种安全高效的...; 关键词：壳聚糖及其衍生物 MIRNA SIRNA 递送载体

载Survivin-siRNA和蛇床子素阳离子脂质体纳米粒的制备工艺优化: 《海南医学院学报》2022年第1期6-12,共7页孙起超白皓天李娅兰孟健男郭雨薇王锐; 哈尔滨市应用技术研究与开发项目(2016RAQXJ197)。; 目的:利用脂质体可同时装载水溶性成分和脂溶性成分的特点,制备载Survivin-siRNA和蛇床子阳离子脂质体纳米粒。方法:以膜材比、药脂比、超声时间和旋蒸温度为考察因素,采用正交试验法优化蛇床子素阳离子脂质体制备工艺。采用控制变量法...; 关键词：SIRNA 阳离子脂质体薄膜分散法制备工艺

Optimization of preparation process of cationic liposome nanoparticles containing Survivin-siRNA and osthol: 《Journal of Hainan Medical University》2022年第1期7-13,共7页Qi-Chao Sun Hao-Tian Bai Ya-Lan Li Jian-Nan Meng Yu-Wei Guo Rui Wang; Harbin Applied Technology Research and Development Project(No.2016RAQXJ197)。; Objective:To prepare cationic liposome nanoparticles loaded with survivin-siRNA and Cnidium monnieri based on the ability of liposomes to contain both water-soluble and lipid soluble components.Methods:The preparation...; 关键词：SIRNA Cationic liposomes Film dispersion method Preparation technology

鸡卵清提取液诱导293T细胞高表达tRFs&tiRNAs分子及细胞功能验证: 《中国细胞生物学学报》2021年第11期2158-2168,共11页阮光萍姚翔何洁莫平王凯杨再玲庞荣清朱向情潘兴华; 云南省科技计划项目重大科技专项(批准号:2018ZF007);云南省重点项目(批准号:2018FA041、202101AS070039);云南省面上项目(批准号:202101AT070212);国家自然科学基金(批准号:31970515);中国人民解放军联勤保障部队第920医院院管课题(批准号:2019YGB17、2019YGA05)资助的课题。; tRNA源性片段(tRNA-derived fragments,tRFs)和tRNA源性应激诱导RNAs(tRNA-derived stress-induced RNAs,tiRNAs)是tRNAs的衍生片段,属于短的非编码RNA家族,通过转录、翻译、信号通路等途径参与复杂的生物反应。该文旨在验证鸡卵清提取...; 关键词：tRFs&tiRNAs分子 293T细胞差异表达转染细胞功能验证

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