KINASE

作品数：737被引量：2933H指数：21
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相关领域：医药卫生生物学更多>>
相关作者：陈珈王学臣王勇博程涵马向东更多>>
相关机构：华中科技大学中国科学院中国医科大学吉林大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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A phosphoinositide kinase triggers migrasome formation
《Cell Research》2023年第8期577-578,共2页Yan Zhen Harald Stenmark 
Migrating cells leave behind them a trace of large vesicles known as migrasomes,which are formed from retraction fibers by mechanisms that are incompletely understood.Now,Ding et al.show that the phosphoinositide PIP2...
关键词：fibers INCOMPLETE TRAIL 
Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington＇s disease models被引量：4
《Cell Research》2017年第12期1441-1465,共25页Meng Yu Yuhua Fu Yijian Liang Haikun Song Yao Yao Peng Wu Yuwei Yao Yuyin Pan Xue Wen Lixiang Ma Saiyin Hexige Yu Ding Shouqing Luo Boxun Lu 
The authors wished to thank National Natural Science Foundation of China and Na- tional Key Research and Development Program of China （NSFC 91649105, 2016YFC0905100, and NSFC 31422024） for funding supports. FY is supported by China Postdoctoral Science Foundation （2016M601495）, SL is supported by Medical Research Council （MR/M023605/1）.
Most neurodegenerative disorders are associated with accumulation of disease-relevant proteins. Among them, Huntington disease （HD） is of particular interest because of its monogenetic nature. HD is mainly caused by...
关键词：PolyQ high-throughput screening protein homeostasis KINASE positive feedback mechanism neurodegenerative disorders 
Regulation of mATG9 trafficking by Src- and ULK1mediated phosphorylation in basal and starvation-induced autophagy被引量：4
《Cell Research》2017年第2期184-201,共18页Changqian Zhou Kaili Ma Ruize Gao Chenglong Mu Linbo Chen Qiangqiang Liu Qian Luo Du Feng Yushan Zhu Quan Chen 
We thank Haiteng Deng and Wenhao Zhang （Tsinghua University, China） for mass spectrometry analysis. We are deeply grateful to Professor Wei Liu （Zhejiang University, China） for his constructive suggestions and critical reading of the manuscript. This study was supported by the Ministry of Science and Technology of China （2016YFA0500201） to QC, the National Natural Science Foundation of China （31671441, 301520103904 and 31471300） to YZ and QC, and the CAS Key project of Frontier Science （QYZDJ- SSW-SMC004） and Nankai University undergraduate innovation research program （21060055338） to YZ.
Autophagy requires diverse membrane sources and involves membrane trafficking of mATG9, the only membrane protein in the ATG family. However, the molecular regulation of mATG9 trafficking for autophagy initiation rema...
关键词：AUTOPHAGY mATG9 trafficking Src kinase ULK1 kinase basal autophagy 
Ligand stimulation of CD95 induces activation of PIk3 followed by phosphorylation of caspase-8被引量：1
《Cell Research》2016年第8期914-934,共21页Christina Helmke Monika Raab Franz Rodel Yves Matthess Thomas Oellerich Ranadip Mandal Mourad Sanhaji Henning Urlaub Claus Rodel Sven Becker Klaus Strebhardt 
Upon interaction of the CD95 receptor with its ligand, sequential association of the adaptor molecule FADD （MORT1）, pro-forms of caspases-8/10, and the caspase-8/10 regulator c-FLIP leads to the formation of a death...
关键词：polo-like kinase CASPASE-8 CD95/Fas receptor apoptosis kinase regulation 
ERK kinase phosphorylates and destabilizes the tumor suppressor FBW7 in pancreatic cancer被引量：20
《Cell Research》2015年第5期561-573,共13页Shunrong Ji Yi Qin Si Shi Xiangyuan Liu Hongli HU Hu Zhou Jing Gao Bo Zhang Wenyan Xu Jiang Liu Dingkong Liang Liang Liu Chen Liu Jiang Long Haijun Zhou Paul J Chiao Jin Xu Quanxing Ni Daming Gao Xianjun Yu 
We thank HuanYu Xia for assistance in collecting the patient data. We thank Fengqun Zhang, Min Chen, Xiangling Chen, Liyan Gong, Binghai Cui, Huafang Ouyang and Xiaoduo Xie for technical support. This work was supported by the National Natural Science Foundation of China （81372651, 81201900, 81172276 and 81101565）, the Sino-German Center （GZ857）, and the PhD Programs Foundation of the Ministry of Education of China （20120071120104）.
F-box and WD repeat domain-containing 7 （FBW7） is the substrate recognition component of the Skpl-Cull-F- box （SCF） ubiquitin ligase complex and functions as a major tumor suppressor by targeting various oncoprote...
关键词：KRAS pancreatic cancer ERK FBW7 
Arabidopsis phosphatidylinositol monophosphate 5-kinase 2 is involved in root gravitropism through regulation of polar auxin transport by affecting the cycling of PIN proteins被引量：8
《Cell Research》2012年第3期581-597,共17页Yu Mei Wen-Jing Jia Yu-Jia Chu Hong-Wei Xue 
Phosphatidylinositoi monophosphate 5-kinase （PIP5K） catalyzes the synthesis of PI-4,5-bispbosphate （Ptdlns（4,5） P2） by phosphorylation of PI-4-phosphate at the 5 position of the inositol ring, and is involved in...
关键词：ARABIDOPSIS phosphatidylinositol monophosphate 5-kinase 2 （PIP5K2） root development polar auxin transport vesicle trafficking 
Serum inducible kinase is a positive regulator of cortical dendrite development and is required for BDNF-promoted dendritic arborization被引量：1
《Cell Research》2012年第2期387-398,共12页Shun-Ling Guo Guo-He Tan Shuai Li Xue-Wen Cheng Ya Zhou Yun-Fang Jia Hui Xiong Jiong Tao Zhi-Qi Xiong 
Serum inducible kinase （SNK）, also known as polo-like kinase 2 （PLK2）, is a known regulator of mitosis, synapto- genesis and synaptic homeostasis. However, its role in early cortical development is unknown. Herein...
关键词：PLK2 MORPHOGENESIS BDNF ERK transcription 
Wnt signaling through T-cell factor phosphorylation被引量：6
《Cell Research》2011年第7期1002-1012,共11页Sergei Y Sokol 
Embryonic signaling pathways often lead to a switch from default repression to transcriptional activation of target genes. A major consequence of Wnt signaling is stabilization of β-catenin, which associates with T-c...
关键词：TCF Wnt PHOSPHORYLATION β-catenin Homeodomain-interacting protein kinase Nemo-like kinase 
Regulation and function of TPL-2, an IkB kinase-regulated MAP kinase kinase kinase被引量：6
《Cell Research》2011年第1期131-145,共15页
The IkB kinase （IKK） complex plays a well-documented role in innate and adaptive immunity. This function has been widely attributed to its role as the central activator of the NF-kB family of transcription factors. ...
关键词：ABIN-2 COT IKK MAP3K8 MAP kinase TLR TPL-2 NF-kB p105 
TRAF2-MLK3 interaction is essential for TNF-α-induced MLK3 activation被引量：1
《Cell Research》2010年第1期89-98,共10页Gautam Sondarva Chanakya N Kundu Suneet Mehrotra Rajakishore Mishra Velusamy Rangasamy Pradeep Sathyanarayana Rajarshi S Ray Basabi Rana Ajay Rana 
Mixed lineage kinase 3 （MLK3） is a mitogen-activated protein kinase kinase kinase that is activated by tumor necrosis factor-α （TNF-α） and specifically activates c-Jun N-terminal kinase （JNK） on TNF-a stimulat...
关键词：c-Jun N-terminal kinase （JNK） tumor necrosis factor-α （TNF-α） mixed lineage kinase （MLK3） TNF receptorassociated factors （TRAFs） 
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