LUPUS

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  • 期刊=Signal Transduction and Targeted Therapyx
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2D4,a humanized monoclonal antibody targeting CD132,is a promising treatment for systemic lupus erythematosus
《Signal Transduction and Targeted Therapy》2024年第12期5693-5707,共15页Huiqi Yin Liming Li Xiwei Feng Zijun Wang Meiling Zheng Junpeng Zhao Xinyu Fan Wei Wu Lingyu Gao Yijing Zhan Ming Zhao Qianjin Lu 
supported by following fundings:the National Key R&D Program of China(No.2022YFC3601800);the CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-059);non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(No.2021-RC320-001,No.2020-RC320-003);the Special Program of National Natural Science Foundation of China(NO.32141004);the Special Research Fund for Central Universities,Peking Union Medical College(No.3332023075);Natural Science Foundation of Jiangsu Province(No.BK20230130);National Natural Science Foundation of China(No.82302982).
Current therapies for systemic lupus erythematosus that target a particular factor or cell type exhibit limited effectiveness.To address this limitation,our focus was on CD132,a subunit common to six inflammatory fact...
关键词：CD13 LUPUS ERYTHEMATOSUS 
Neddylation is a novel therapeutic target for lupus by regulating double negative T cell homeostasis被引量：1
《Signal Transduction and Targeted Therapy》2024年第2期738-750,共13页Yun Zhang Lijun Du Chenxi Wang Zhangsheng Jiang Qingchi Duan Yiping Li Zhijun Xie Zhixing He Yi Sun Lin Huang Liwei Lu Chengping Wen 
supported by Regional Innovation and Development Joint Fund of the National Foundation of China(U21A20402)to C.W.;National Natural Science Foundation of China(No.82074375);the Research Project of Zhejiang Chinese Medical University(No.2023JKZDZC01)to Y.Z.;Chongqing International Institute for Immunology(2020YJC10)to L.L.;National Natural Science Foundation of China(No.82074217)to Z.H.
Systemic lupus erythematosus(SLE),a severe autoimmune disorder,is characterized by systemic inflammatory response,autoantibody accumulation and damage to organs.The dysregulation of double-negative(DN)T cells is consi...
关键词：INACTIVATION DOUBLE finding 
Repression of interferon regulatory factor-4(IRF4)hyperactivation restricts murine lupus被引量：2
《Signal Transduction and Targeted Therapy》2023年第6期2475-2477,共3页Shijun He Huihua Ding Li Chen Yiwei Shen Yuting Liu Fenghua Zhu Xiaoqian Yang Nan Shen Zemin Lin Jianping Zuo 
the National Natural Science Foundation of China(Grant Number:81903882,81871240,82001709);the Science and Technology Commission of Shanghai Municipality(Grant Number:22ZR1473700,21S11907700);"Science and Technology Innovation Action Plan"medicine innovation fund by Science and Technology Commission of Shanghai Municipality(Grant Number:21Y31900200).
Dear Editor,Hyperactivation of the type I interferon(IFN)signature has been observed in several systemic autoimmune conditions,and the type I IFN receptor antagonist Saphnelo(anifrolumab-fnia)has been approved in 2021...
关键词：LUPUS INTERFERON ACTIVATION 
Low-dose IL-2 mitigates glucocorticoid-induced Treg impairment and promotes improvement of SLE被引量：3
《Signal Transduction and Targeted Therapy》2023年第5期2041-2043,共3页Haotian Zhou Xiaozhen Zhao Ruijun Zhang Miao Miao Wenwen Pei Zijun Li Yimin Li Jing He Zhanguo Li Xiaolin Sun 
supported by the Natural Science Foundation of China (81971520,32141004,82171775);Project (RDGS2022-05) supported by Peking University People's Hospital Scientific Research Development Funds;Beijing Children's Hospital Young Investigator Program.
Dear Editor,Previous studies have proved that regulatory T cell(Treg)insufficiency contributed to the development of autoimmune conditions including systemic lupus erythematosus(SLE).Conventional immunosuppressive tre...
关键词：GLUCOCORTICOID LUPUS ERYTHEMATOSUS SLE 
Autoantibodies targeting to GPER1 promote monocyte cytokines production and inflammation in systemic lupus erythematosus被引量：4
《Signal Transduction and Targeted Therapy》2023年第4期1354-1356,共3页Xinwei Zhang Hongyan Qian Yangchun Chen Yuanhui Wu Yuechi Sun Yan He Shiju Chen Guixiu Shi Yuan Liu 
the Natural Science Foundation of China(82101841,X.Z.,81601384,H.Q.,81971536,82171779,G.S.,and 81971496,Y.L.);the Natural Science Foundation of Fujian Province(2020J05301,X.Z.,2021J05292,H.Q.);the Scientific and Technological Projects of Xiamen City(3502Z20209004,G.S.and 3502Z20214ZD3001,X.Z.)。
Dear Editor,Systemic lupus erythematosus(SLE),one of the most common autoimmune diseases in reproductive females,is a multifactorial disease involving genetic,environmental,and hormonal factors.1 It occurs at a 9:1 fe...
关键词：ANTIBODIES LUPUS ERYTHEMATOSUS 
Correction To:Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus
《Signal Transduction and Targeted Therapy》2022年第10期3969-3972,共4页
In the process of collating the raw data,the authors noticed two inadvertent mistakes occurred in Fig.4b and Fig.6g(and the corresponding uncropped images in“Supplementary Data 2-Figure 6g”)that need to be corrected...
关键词：STRIPPING Figure CORRECTION 
Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus被引量：4
《Signal Transduction and Targeted Therapy》2022年第3期840-855,共16页Xiaojuan Han Tianshu Xu Congzhu Ding Dandan Wang Genhong Yao Hongwei Chen Qijun Fang Gang Hu Lingyun Sun 
This research was supported by grants from the National Key R&D Program of China(2020YFA0710800);the Key Program of National Natural Science Foundation of China(81930043);the Major International(Regional)Joint Research Project of China(81720108020);the National Natural Science Foundation of China(81903587);the Jiangsu Provincial Key Research and Development Program(BE2020621);the China Postdoctoral Science Foundation(2019M661807&2021T140315);the Open Project of Chinese Materia Medica First-Class Discipline of Nanjing University of Chinese Medicine(2020YLXK006).
Neuropsychiatric lupus(NPSLE)is a frequent manifestation of systemic lupus erythematosus(SLE)that occurs in 40-90%of SLE patients;however,the underlying mechanisms remain elusive,causing a severe lack of therapeutic t...
关键词：LUPUS COORDINATED pathology 
AIM2 deficiency in B cells ameliorates systemic lupus erythematosus by regulating Blimp-1-Bcl-6 axis-mediated B-cell differentiation被引量：6
《Signal Transduction and Targeted Therapy》2021年第10期3085-3095,共11页Ming Yang Di Long Longyuan Hu Zhidan Zhao Qianwen Li Yunkai Guo Zhenghao He Ming Zhao Liwei Lu Fen Li Hai Long Haijing Wu Qianjin Lu 
supported by the National Natural Science Foundation of China(Nos.81972943,81830097);Hunan Talent Young Investigator(No.2019RS2012);Hunan Outstanding Young Investigator(No.2O2OJJ2O55)CAMS Innovation Fund for Medical Sciences(CIFMS)(2019-I2M-5-033);Chongqing International Institute for Immunology(2020YJC10).
Absent in melanoma 2(AIM2)has been reported to be a component of inflammasomes in innate immune cells.Surprisingly,AIM2 is expressed by B cells,and higher AIM2 expression is observed in the B cells from lupus patients...
关键词：LUPUS SPLEEN AIM2 
High salt diet accelerates the progression of murine lupus through dendritic cells via the p38 MAPK and STAT1 signaling pathways被引量：8
《Signal Transduction and Targeted Therapy》2020年第1期2082-2094,共13页Ze Xiu Xiao Xiaojiang Hu Ximei Zhang Zhigang Chen Julie Wang Ke Jin Feng Lin Cao Baoqing Sun Joseph A.Bellanti Nancy Olsen Song Guo Zheng 
supported by the National Key R&D Program of China[2017YFA0105801];the Zhujiang Innovative and Entrepreneurial Talent Team Award of Guangdong Province[2016ZT06S252];the National Natural Science Foundation of China[Nos.81871224,81671611,81901657];the Natural Science Foundation of Guangdong Province[grant no.2014A030308005](all to Z.X.X.),NIH R01 AR059103,and the NIH STAR award(to S.G.Z.).
The increased incidence of systemic lupus erythematosus(SLE)in recent decades might be related to changes in modern dietary habits.Since sodium chloride(NaCl)promotes pathogenic T cell responses,we hypothesize that ex...
关键词：STAT1 LUPUS prevention 
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