This work was partially supported by grants from the National Natural Science Foundation of China(81922071 to Y.Zhang,81872915/82073904 to M.-W.W.and 81773792/81973373 to D.Y.);the National Key Basic Research Program of China(2019YFA0508800 to Y.Zhang,2018YFA0507000 to M.-W.W.and 2018ZX09711002-002-005 to D.Y.);Zhejiang Province Science Fund for Distinguished Young Scholars(LR19H310001 to Y.Zhang);Key R&D Projects of Zhejiang Province(2021C03039 to Y.Zhang);National Science&Technology Major Project of China-Key New Drug Creation and Manufacturing Program(2018ZX09735-001 to M.-W.W.and 2018ZX09711002-002-005 to D.Y.);Novo Nordisk-CAS Research Fund(NNCAS-2017-1-CC to D.Y.).
Melanocortin-4 receptor(MC4R)plays a central role in the regulation of energy homeostasis.Its high sequence similarity to other MC receptor family members,low agonist selectivity and the lack of structural information...
supported by the National Natural Science Foundation of China Key Project(91332205,81130024,81630030to T.L.);National Natural Science Foundation of China(8157051859 to W.D.et al.);National Key Technology R&D Program of the Ministry of Science and Technology of China(2016YFC0904300 to T.L.);National Natural Science Foundation of China/Research Grants Council of Hong Kong Joint Research Scheme(8141101084 to T.L.);Sichuan Science&Technology Department(2015JY0173 to Q.W.);1.3.5 Project for disciplines of excellence,West China Hospital of Sichuan University(ZY2016103,ZY2016203 to T.L.)
Antipsychotic-induced metabolic disturbance(AIMD) is a common adverse effect of antipsychotics with genetics partly underpinning variation in susceptibility among schizophrenia patients. Melanocortin4 receptor(MC4 R) ...