Overexpression of P-glycoprotein(P-gp),encoded by the MDR1 gene,in tumor cells curtails the efficacy of chemotherapy,leading to multidrug resistance(MDR),which can be reversed by the P-gp inhibitor.Capsaicin,the princ...
Supported by the "Regional Specialized Industry Development Program",Ministry of Trade,Industry,and Energy(MOTIE),Korea;supervised by the Korea Institute for Advancement of Technology(KIAT)
The exploration and identification of antiproliferative phytochemicals have received increased attention in medicinal chemistry. In particular, research focused on the toxicology of marine natural products has increas...