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Diet high in branched-chain amino acid promotes PDAC development by USP1-mediated BCAT2 stabilization被引量：3
《National Science Review》2022年第5期115-124,共10页Jin-Tao Li Kai-Yue Li Ying Su Yuan Shen Ming-Zhu Lei Fan Zhang Miao Yin Zheng-Jun Chen Wen-Yu Wen Wei-Guo Hu Dan Su Jia Qu Qun-Ying Lei 
supported by the Ministry of Science and Technology of China(2020YFA0803400/2020YFA0803402 and 2019YFA0801703);the National Natural Science Foundation of China(81790250/81790253,9195920,8187224,81872240,81802745 and 82002951);the Innovation Program of the Shanghai Municipal Education Commission(N173606);the China Postdoctoral Science Foundation(2021M690676)。
BCAT2-mediated branched-chain amino acid(BCAA)catabolism is critical for pancreatic ductal adenocarcinoma(PDAC)development,especially at an early stage.However,whether a high-BCAA diet promotes PDAC development in viv...
关键词：USP1 DEUBIQUITYLATION BCAT2 PANIN PDAC 
Amorphous molybdenum sulfide mediated EDTA with multiple active sites to boost heavy metal ions removal被引量：2
《Chinese Chemical Letters》2021年第9期2797-2802,共6页Qi Huang Yizhong Zhang Wei Zhou Xiang Huang Yiliang Chena Xin Tan Tao Yu 
supported by the Natural Science Foundation of Tianjin(No.18JCYBJC17700);the National Natural Science Foundation of China(Nos.21406164,21466035 and 22066022);the National Key Basic Research and Development Program of China(973 Program,No.2014CB239300)。
The rational design of strong affinity adsorbents for heavy metal ions removal remains a critical challenge for water treatment.In this study,amorphous molybdenum sulfide composites(EDTA-MoSx(x=2,3))were fabricated vi...
关键词：Amorphous phase MoS_(2) MoS_(3) Adsorption Heavy metal ions DFT calculations 
Strain-mediated insulator-metal transition in topotactically hydro-reduced SrFeO_(2)
《Science China(Physics,Mechanics & Astronomy)》2021年第8期114-119,共6页Shuang Chen Jiali Zhao Qiao Jin Shan Lin Shengru Chen Hongbao Yao Jiaou Wang Zhen Fan Er-Jia Guo Haizhong Guo 
supported by the National Key Basic Research Program of China(Grant Nos.2020YFA0309100,and 2019YFA0308500);the Program for the Innovation Team of Science and Technology in University of Henan(Grant No.20IRTSTHN014);the Excellent Youth Foundation of He’nan Scientific Committee(Grant No.202300410356);the National Natural Science Foundation of China(Grant No.11974390);the Beijing Nova Program of Science and Technology(Grant No.Z191100001119112);the Beijing Natural Science Foundation(Grant No.2202060);the Strategic Priority Research Program(B)of the Chinese Academy of Sciences(Grant No.XDB33030200)。
Controlling oxygen redox reactions in transition metal oxides offers an attractive route to tune their physical properties;a topotactic structural transformation from their parent phases effectively modifies the elect...
关键词：FERRITE HYDROGENATION insulator-metal transition infinite layers electronic states 
Nanozyme-mediated elemental biogeochemical cycling and environmental effects被引量：2
《Science China Earth Sciences》2021年第7期1015-1025,共11页Zhi-Lai CHI Guang-Hui YU 
supported by the National Natural Science Foundation of China(Grant No.41977271);the National Key Basic Research Program of China(Grant No.2020YFC1806803)。
In Earth systems,thousands of terragrams(Tg)(1 Tg=10^(12) g)of mineral nanoparticles move around annually.Some mineral nanoparticles have exhibited unexpected intrinsic enzyme-like characteristics(so called“mineral n...
关键词：Nanozymes PEROXIDASE Nanominerals Reactive oxygen species Biogeochemical cycles 
Inflammation-induced inhibition of chaperone-mediated autophagy maintains the immunosuppressive function of murine mesenchymal stromal cells被引量：4
《Cellular & Molecular Immunology》2021年第6期1476-1488,共13页Jie Zhang Jiefang Huang Yuting Gu Mingxing Xue Fengtao Qian Bei Wang Wanlin Yang Hongshuang Yu Qiwei Wang Xin Guo Xinyuan Ding Jina Wang Min Jin Yanyun Zhang 
supported by the Ministry of Science and Technology of China(2015CB943300 and 2011CB966200);the National Natural Science Foundation of China(81873447 and 81670540);The Program of Science and Technology Commission of Shanghai Municipality(19ZR1409200 and 19ZR1430900);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA01040000).
Macroautophagy has been implicated in modulating the therapeutic function of mesenchymal stromal cells(MSCs).However,the biological function of chaperone-mediated autophagy(CMA)in MSCs remains elusive.Here,we found th...
关键词：chaperone-mediated autophagy mesenchymal stromal cells immunosuppressive capacity inflammatory microenvironment 
Structural basis for nucleosome-mediated inhibition of cGAS activity被引量：10
《Cell Research》2020年第12期1088-1097,共10页Duanfang Cao Xiaonan Han Xiaoyi Fan Rui-Ming Xu Xinzheng Zhang 
the National Key R&D Program of China(2017YFA0504700,2019YFA0508900);the Ministry of Science and Technology of China;the National Natural Science Foundation of China(31930069,31521002 and 31991162);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB37040101,XDB37010101).X.Z.received scholarships from the'National Thousand(Young)Talents Program,from the Office of Global Experts Recruitment in China.D.C.is sponsored by the Youth Innovation Promotion Association at the Chinese Academy of Sciences(2018124).
Activation of cyclic GMP-AMP synthase(cGAS)through sensing cytosolic double stranded DNA(dsDNA)plays a pivotal role in innate immunity against exogenous infection as well as cellular regulation under stress.Aberrant a...
关键词：complex. ACTIVATION COMPLEXES 
Cleavable bimetallic-organic polymers for ROS mediated cascaded cancer therapy under the guidance of MRI through tumor hypoxia relief strategy被引量：1
《Science China Chemistry》2020年第7期936-945,共10页Haozhe He Lihua Du Min Tan Yali Chen Liejing Lu Yongcheng An Yong Wang Xiaoxia Li Bo Li Jun Shen Jun Wu Xintao Shuai 
supported by the National Natural Science Foundation of China (51933011, 31971296, 21805314);the National Basic Research Program of China (2015CB755500);the Natural Science Foundation of the Guangdong Province (2014A030312018)。
Despite recent advances in tumor treatment, reactive oxygen species(ROS)-mediated therapy, such as photodynamic therapy(PDT) and chemical dynamic therapy(CDT), remains challenging mainly due to hypoxia in tumor microe...
关键词：reactive oxygen species photodynamic therapy chemodynamic therapy ROS sensitive drug releases MRI imaging 
Hydroxyl radicals-mediated oxidative cleavage of the glycosidic bond in cellobiose by copper catalysts and its application to low-temperature depolymerization of cellulose被引量：6
《Chinese Journal of Catalysis》2020年第7期1073-1080,共8页Fangwei Gu Haichao Liu 
国家重点基础研究发展计划(2016YFB0701100);国家自然科学基金(21690081,21433001,21832001,21821004);北京分子科学国家实验室基金(BNLMS-CXXM-201905).
As the most abundant source of biomass in nature for sustainable production of fuels and chemicals,efficient depolymerization of cellulose under mild conditions,due to the difficulty in selective cleavage of itsβ-1,4...
关键词：Cellulose depolymerization CELLOBIOSE Hydroxyl radical Oxidative cleavage Glycosidic bond 
Visible-light-mediated external-reductant-free reductive cross coupling of benzylammonium salts with(hetero)aryl nitriles被引量：4
《Science China Chemistry》2019年第11期1519-1524,共6页Meng Miao Li-Li Liao Guang-Mei Cao Wen-Jun Zhou Da-Gang Yu 
supported by the National Natural Science Foundation of China(21772129,21801176);the The National Basic Research Program of China from the Minstry of Science and Technology of China(2015CB856600);Sichuan Science and Technology Program(2019YJ0379);Neijiang Normal University(KF10076);the Fundamental Research Funds for the Central Universities(YJ201516)
Herein we report a novel visible-light-mediated external reductant-free reductive cross coupling for the construction of C sp2–C sp3 bonds.A variety of benzylammonium salts underwent selective coupling with(hetero)ar...
关键词：REDUCTIVE cross coupling VISIBLE light external-reductant-free 
SENP6-mediated M18BP1 deSUMOylation regulates CENP-A centromeric localization被引量：2
《Cell Research》2019年第3期254-257,共4页Hang Fu Nan Liu Qiang Dong Chunxiao Ma Jing Yang Jun Xiong Zhuqiang Zhang Xiangbing Qi Chang Huang Bing Zhu 
the Ministry of Science and Technology of China (2017YFA0504200 and 2015CB856200);the National Natural Science Foundation of China (31701101, 31730047, 31521002, and 31425013);the Chinese Academy of Sciences (QVZDYSSW- SMC031, XDB08010103, and XDPB1001);the Youth Innovation Promotion Association of the Chinese Academy of Sciences (2017133 and 2018127).
Dear Editor, Centromeres are critical for the faithful inheritanee of genetic information during cell division and maintenance of centromere identity is vital for genome integrity. The identity of centromeres is epige...
关键词：SENP6-mediated M18BP1 deSUMOylation CENP-A 
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