MONOCLONAL_ANTIBODY

作品数：408被引量：864H指数：13
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Drug development for chronic hepatitis B functional cure:Recent progress
《World Journal of Hepatology》2025年第4期31-42,共12页Ting Liu He Wang Yue Zhao Ying-Xin Wang Xue Xing Peng Gao 
Chronic hepatitis B virus(HBV)infection affects approximately 254 million individuals globally,contributing to significant morbidity and mortality due to HBV-related liver failure and cirrhosis,which result in million...
关键词：Chronic hepatitis B infection Therapeutic targets Monoclonal antibody RNA interference IMMUNOMODULATORS 
Engineering hyaluronic acid-based nanoassemblies for monoclonal antibody delivery-design,characterization,and biological insights
《Nano Research》2024年第10期9111-9125,共15页Ana M.López-Estévez Y.Zhang María Medel Iker Arriaga Lucía Sanjurjo Cristian Huck-Iriart Nicola G.A.Abrescia María J.Vicent Defang Ouyang Dolores Torres María José Alonso 
supported by the government of Xunta de Galicia(Competitive Reference Groups,Consellería de Educación e Ordenación Universitaria,Xunta de Galicia,No.ED431C 2021/17);by the ISCⅢ thorough AES 2020,Award No.AC20/00028 and within the framework of EuroNanoMed Ⅲ;part of the project Proof of Concept(No.PDC2021-120929-I00);financed by the Spanish Ministry of Science and Innovation-AEI/10.13039/501100011033;the European Union NextGenerationEU/PRTR;the Spanish Ministry of Science,Innovation and Universities(No.FPU18/00095).
The current spotlight of cancer therapeutics is shifting towards personalized medicine with the widespread use of monoclonal antibodies(mAbs).Despite their increasing potential,mAbs have an intrinsic limitation relate...
关键词：monoclonal antibody NANOPARTICLES hyaluronic acid CHARACTERIZATION particle size computational modeling 
A rationally designed CD19 monoclonal antibody-triptolide conjugate for the treatment of systemic lupus erythematosus
《Acta Pharmaceutica Sinica B》2024年第10期4560-4576,共17页Lai Wang Haoyuan Yin Jiao Jiang Qilin Li Changxing Gao Wenrui Li Bo Zhang Yue Xin Hongyang Li Ming Zhao Qianjin Lu 
supported by the National Key R&D Program of China(2022YFC3601800 to Qianjin Lu);the National Natural Science Foundation of China(No.82304509 to Lai Wang);the Natural Science Foundation of Jiangsu Province(BK20230131 to Lai Wang);the Special Program of National Natural Science Foundation of China(No.32141004 to Qianjin Lu);the CAMS Innovation Fund for Medical Sciences(No.2021-I2M-1-059 to Qianjin Lu,China);the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences(2020-RC320-003 to Qianjin Lu).
Tripterygium wilfordii Hook F(TWHF)is a traditional Chinese medicine widely used in the treatment of systemic lupus erythematosus(SLE),with triptolide(TP)as its main active ingredient.However,its side effects also ind...
关键词：Systemic lupus erythematosus TRIPTOLIDE CD19 Antibody‒drug conjugate B cells Reproductive toxicity Synergistic effect Targeted therapy 
A multi-colloidal gold immunochromatography assay for rapid and simultaneous detection of 13 herbicides
《Nano Research》2024年第9期8368-8376,共9页Qianqian Lu Xinxin Xu Aihua Qu Liqiang Liu Yuzhe Li Maozhong Sun Chuanlai Xu Hua Kuang 
supported by the National Natural Science Foundation of China(Nos.22306074 and 222360020);the National Key Research and Development Program of China(Nos.2023YFF1105003 and 2022YFA1207300);the grants from Jiangsu province(Nos.CX(22)1013,BK20212014,and M20221006).
Herbicide residues in agricultural products can have adverse effects on the environment and human health,therefore,there is an urgent need to establish a sensitive,rapid,and wide-ranging detection method.In this study...
关键词：phenylurea herbicides sulfonylurea herbicides monoclonal antibody immunochromatographic assay WHEAT 
Safety of teplizumab in patients with high-risk for diabetes mellitus type 1:A systematic review
《World Journal of Diabetes》2024年第8期1793-1801,共9页Venkata Buddhavarapu Gagandeep Dhillon Harpreet Grewal Pranjal Sharma Rahul Kashyap Salim Surani 
BACKGROUND The incidence of diabetes mellitus type 1(DM1)has been rising worldwide because of improvements in diagnostic techniques and improved access to care in countries with lower socioeconomic status.A new anti-C...
关键词：Teplizumab Diabetes mellitus type 1 Adverse effects Monoclonal antibody Systematic review 
Monoclonal antibodies and aptamers:The future therapeutics for Alzheimer’s disease
《Acta Pharmaceutica Sinica B》2024年第7期2795-2814,共20页Alvaro Barrera-Ocampo 
funded by Ministerio de Ciencia,Tecnologia e Innovacion de Colombia(Grants No.CT 775-2018,CT 80740-460-2021 and CT 86980-460-2021,Colombia);Universidad Icesi e Convocatoria Interna(Grant No.CA041370,Colombia).
Alzheimer’s disease(AD)is considered the most common and prevalent form of dementia of adult-onset with characteristic progressive impairment in cognition and memory.The cure for AD has not been found yet and the tre...
关键词：Aβ Monoclonal antibody DNA aptamers Cognitive impairment Alzheimer’s disease Clinical trials Immunotherapy Machine learning 
Antibodies Targeting a Conserved Surface Polysaccharide Are Protective Against a Wide Range of Microbial Pathogens Producing β-1-6-Linked Poly-N-Acetylglucosamine(PNAG)
《Engineering》2024年第7期69-76,共8页Xi Lu Guoqing Li Jing Pang Xinyi Yang Colette Cywes-Bentley Xuefu You Gerald B.Pier 
supported by the National Natural Science Foundation of China(32141003 and 81703399);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(CIFMS,2021-I2M-1-026).
The b-1-6-linked poly-N-acetylglucosamine(PNAG)polymer is a conserved surface polysaccharide produced by many bacteria,fungi,and protozoan(and even filarial)parasites.This wide-ranging expression makes PNAG an attract...
关键词：Poly-N-acetylglucosamine Conjugate vaccine Monoclonal antibody 
Quantitative assessment of the breast cancer marker HER2 using a gold nanoparticle-based lateral flow immunoassay被引量：1
《Nano Research》2024年第6期5452-5460,共9页Liya Ye Xinxin Xu Aihua Qu Liqiang Liu Chuanlai Xu Hua Kuang 
the National Natural Science Foundation of China(No.22236002);National Key R&D Program(Nos.2023YFF1105003 and 2022YFA1207300).
Human epidermal growth factor receptor 2(HER2)is an important biomarker for detection and treatment of breast cancer.In this study,we developed monoclonal antibodies against the extracellular domain(ECD)of HER2 and es...
关键词：human epidermal growth factor receptor 2 breast cancer monoclonal antibody QUANTITATIVE lateral flow immunoassay 
IMpower210:A phase Ⅲ study of second-line atezolizumab vs. docetaxel in East Asian patients with non-small cell lung cancer
《Chinese Journal of Cancer Research》2024年第2期103-113,共11页Yi-Long Wu Shun Lu Gongyan Chen Jianxing He Jifeng Feng Yiping Zhang Liyan Jiang Hongming Pan Jianhua Chang Jian Fang Amy Cai Lilian Bu Jane Shi Jinjing Xia 
funded by F. Hoffmann-La Roche Ltd. F. Hoffmann-La Roche Ltd sponsored the IMpower210 study。
Objective: IMpower210(NCT02813785) explored the efficacy and safety of single-agent atezolizumab vs.docetaxel as second-line treatment for advanced non-small cell lung cancer(NSCLC) in East Asian patients.Methods: Key...
关键词：Atezolizumab East Asia non-small cell lung cancer programmed death-ligand 1 inhibitors monoclonal antibody 
Cancer treatment with biosimilar drugs:A review
《Cancer Innovation》2024年第2期45-62,共18页Shilpa Malakar Emmanuel Nuah Gontor Moses YDugbaye Kamal Shah Sakshi Sinha Priya Sutaoney Nagendra Singh Chauhan 
Director of AYUSH(Chhattisgarh)for laboratory facilities and National Ayush Mission(NAM)Grant award year 2016-17。
Biosimilars are biological drugs created from living organisms or that contain living components.They share an identical amino-acid sequence and immunogenicity.These drugs are considered to be cost-effective and are u...
关键词：BIOLOGICS BIOSIMILARS cancer Escherichia coli monoclonal antibody next-generation sequencing PHARMACOVIGILANCE 
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