目的以雌性和雄性非肥胖糖尿病(nonobese diabetic,NOD)小鼠以及健康对照癌症研究所(institute for cancer research,ICR)小鼠为研究对象,比较分析初始、效应、记忆、耗竭以及调节性CD8^(+)T细胞分化亚群差异,探讨1型糖尿病(type 1 diab...
supported by institutional grants from INSERM and CNRS and by specific grants from CNRS(CNRS IRP CHOLESTIM);the Agence Nationale de la Recherche(ANR-10-BLAN-1509;ANR-11-LABX-Investissement d’Avenir Labex-INFORM;ANR-17CE15-0032)。
T cell activation is a main component of adaptive immunity,which involves two types of signals transmitted by key immune receptors upon engagement with their respective ligands present on the antigen-presenting cells(...