supported by the National Natural Science Foundation of China(No.31371165 and 31571179);the Natural Science Foundation of Fujian Province;China(No.2015J01313);the Youth Research Project of Fujian Provincial Department of Health;China(No.2013-1-21)
supported by the National Natural Science Foundation of China(No.30670772);the Natural Science Foundation of Fujian Province(No.C0620002);the Key Program of Scientific Research of Fujian Medical University(No.09ZD010)