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Genome Editing:From Drosophila to Non-Model Insects and Beyond被引量：1
《Journal of Genetics and Genomics》2016年第5期263-272,共10页Yueping Huang Zhiping Liu Yikang S.Rong 
supported by a grant from the National Natural Science Foundation of China(No.NSFC #31371364)
Insect is the largest group of animals on land.Many insect species inflict economical and health losses to humans.Yet many more benefit us by helping to maintain balances in our ecosystem.The benefits that insects off...
关键词：Insect transgenesis Drosophila Black soldier fly Gene targeting Site-specific recombination Piggybac transposon 
超氧化物歧化酶1基因与果蝇寿命和攀爬能力的关系被引量：1
《中国组织化学与细胞化学杂志》2023年第5期489-495,共7页石玉霞 曹旭婷 朱凯 耿磊 陈冬生 
分子酶学与重大疾病机理研究安徽省重点实验室开放基金(Fzmx202006);安徽省人社厅学术与技术带头人后备人选项目(KJ2018A0320)。
目的观察超氧化物歧化酶1(superoxide dismutase 1,SOD1)基因(sod1)表达对果蝇寿命和运动能力的影响,分析sod1与衰老之间的联系。方法利用RNAi干扰技术,获得sod1敲低果蝇;运用载体构建和显微注射的技术获得sod1过表达效应;通过免疫组织...
关键词：超氧化物歧化酶1基因 果蝇 寿命 衰老 攀爬能力 
A robust,integrated platform for comprehensive analyses of acylcoenzyme As and acyl-carnitines revealed chain length-dependent disparity in fatty acyl metabolic fates across Drosophila development被引量：4
《Science Bulletin》2020年第21期1840-1848,M0004,共10页Sin Man Lam Tianxing Zhou Jie Li Shaohua Zhang Gek Huey Chua Bowen Li Guanghou Shui 
supported by the National Key R&D Program of China(2018YFA0506900,2018YFA0800901);the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA12030211);the National Natural Science Foundation of China(31671226,31871194)。
Acyl-coenzyme A thioesters(acyl-CoAs)denote a key class of intermediary metabolites that lies at the hub of major metabolic pathways.The great diversity in polarity between short-and long-chain acylCoAs makes it techn...
关键词：Acyl-coenzyme As Acyl-carnitines Fatty acids Drosophila High-fat diet β-Oxidation 
Drosophila neuronal injury model allows for temporal dissection of neurodegenerative events
《Neural Regeneration Research》2016年第3期416-417,共2页Barron L.LincolnⅡ Lani C.Keller 
supported by an internal Quinnipiac University Grant-In-Aid to LCK between the years of 2012-2014
Neurodegenerative diseases are extremely prevalent in today’s society and,according to the World Health Organization,are currently listed as the third leading cause of death,following cancer and heart disease（Gammon...
关键词：neuronal degeneration muscular dissection extremely Drosophila disruption currently listed today 
Protein O-GlcNAcylation homeostasis regulates facultative heterochromatin to fine-tune sog-Dpp signaling during Drosophila early embryogenesis被引量：1
《Journal of Genetics and Genomics》2023年第12期948-959,共12页Yaowen Zhang Haibin Yu Dandan Wang Xiaoyun Lei Yang Meng Na Zhang Fang Chen Lu Lv Qian Pan Hongtao Qin Zhuohua Zhang Daan M.F.van Aalten Kai Yuan 
This project has been supported by the National Natural Science Foundation of China(grants 91853108,92153301,31771589,and 32170821 to K.Y,32101034 to F.C);Department of Science and Technology of Hunan Province(grants 2017RS3013,2017XK2011,2018DK2015,2019SK1012,and 2021JJ10054 to K.Y,and the innovative team program 2019RS1010);Central South University(2018CX032 to K.Y,2019zzts046 to Y.Z,2019zzts339 to X.L,2021zzts497 to H.Y,and the innovation-driven team project 2020CX016);D.M.F.v.A.is supported by Wellcome Trust Investigator Award(110061);a Novo Nordisk Foundation Laureate award(NNF21OC0065969).
Protein O-GlcNAcylation is a monosaccharide post-translational modification maintained by two evolutionarily conserved enzymes, O-GlcNAc transferase (OGT) and O-GlcNAcase (OGA). Mutations in human OGT have recently be...
关键词：Protein O-GlcNAcylation DROSOPHILA Early embryogenesis Polycomb repressive complex Facultative heterochromatin Neurodevelopment sog 
果蝇:基因、脑和行为被引量：6
《世界科技研究与发展》2000年第6期46-49,共4页刘力 
本文首先简单回顾了在果蝇研究历史中一些具有里程碑性的研究成果 ,然后着重介绍了以果蝇为实验模型所具有的诸多优势 ,以及在基因、脑、行为框架下的一些最新研究成果和未来的研究方向。
关键词：果蝇 基因 行为 脑结构 脑功能 脑科学 
Effect of copper on the development, protein and esterase isozymes of Drosophila melanogaster
《Integrative Zoology》2006年第2期73-77,共5页Ling DING Yufeng WANG 
supported by the National Natural Science foundation of China (No.30300035);by the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry[No. (2004)527].
Copper is an important ingredient in fungicides,which are used for many economic plants.However,there is concern about the side-effects of copper-based fungicides due to their potential to affect beneficial mites.The ...
关键词：COPPER Drosophila melanogaster esterase isozymes larval development PROTEIN 
Geroprotection from ergothioneine treatment in Drosophila melanogaster by improving intestinal barrier and activation of intestinal autophagy
《Food Science and Human Wellness》2024年第6期3434-3446,共13页Hongyu Pan Qianwang Zheng Yuan Zou Guozhao Luo Mingzhen Tu Na Wang Jingru Zhong Liqiong Guo Junfang Lin 
supported by the National Natural Science Foundation of China(32072646,31772373,and 32001832).
Ergothioneine is a natural amino acid with powerful antioxidant activity.Previous studies have demonstrated that ergothioneine can increase the lifespan of Drosophila melanogaster and Caenorhabditis elegans,and enhanc...
关键词：ERGOTHIONEINE Gut microbiota Intestinal autophagy Intestinal barrier Drosophila melanogaster 
刺玫果提取物抗衰老作用的研究被引量：11
《食品科技》2019年第2期215-220,共6页怀雪 孟永海 王艳艳 王知斌 卞宏生 马智超 孟祥瑛 翟春梅 
哈尔滨市科技创新人才研究专项资金项目(2017RAQXJ125);黑龙江中医药大学研究生创新科研项目(yjscx2017060);黑龙江省博士后科研启动金项目(LBH-Q15137)
将野生刺玫果用80%乙醇回流提取,冻干成粉,测定总黄酮含量。在培养基中添加低(0.115%)、中(0.461%)、高(1.845%)不同浓度的刺玫果冻干粉喂养果蝇,对果蝇寿命及寿命相关行为学指标进行考察。研究发现刺玫果提取物的总黄酮含量为220.6 mg/...
关键词：刺玫果 果蝇 寿命 抗衰老 
Drosophila melanogaster brain invasion pathogenic Wolbachia in central nervous system of the fly被引量：1
《Insect Science》2016年第2期253-264,共12页Anton Strunov Elena Kiseleva 
The pathogenic Wolbachia strain wMelPop rapidly over-replicates in the brain, muscles, and retina of Drosophila melanogaster, causing severe tissue degeneration and premature death of the host. The unique features of ...
关键词：bacterial morphology dynamics BRAIN Drosophila melanogaster electronmicroscopy pathogenic endosymbiont Wolbachia strain wMelPop 
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