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眼部给药的非临床安全性评价实践与挑战被引量：1
《中南药学》2018年第10期1349-1354,共6页孙云霞 李和平 廖琴 
国家科技重大专项课题重大新药创制(课题编号:2015ZX000-002)
随着眼科新药的大量开发,眼科药物的非临床安全性评价迎来了挑战和发展的机遇。眼部给药的药物非临床安全性评价不但要遵循药物非临床安全性评价的一般原则,而且要按照临床给药途径进行眼部局部给药的安全性评价,其试验设计、给药方法...
关键词：眼 眼科新药 眼部给药 非临床安全性评价 实验动物 
Clinical effectiveness of diquafosol ophthalmic solution 3%in Korean patients with dry eye disease:a multicenter prospective observational study被引量：3
《International Journal of Ophthalmology(English edition)》2021年第10期1518-1526,共9页Youngsub Eom Hyo Myung Kim 
Santen Pharmaceuticals,Co.,Ltd。
AIM:To investigate the effectiveness of diquafosol ophthalmic solution 3%administered in Korean patients with dry eye disease in real-world clinical settings.METHODS:Diquafosol was administered for 8 wk to 3 patient g...
关键词：dry eye disease diquafosol ophthalmic solution routine clinical practice 
显微联合手术治疗复杂性眼外伤的临床分析被引量：2
《中华显微外科杂志》2003年第4期264-266,共3页汪振芳 罗益文 胡淑英 林晓峰 
目的　探讨显微联合手术治疗复杂性眼外伤的方法及临床疗效。　方法　应用显微手术包括开放创口修补、前房成形、白内障摘除、玻璃体切除、眼内异物摘除及视网膜复位 ,治疗复杂性眼外伤 14 2 9眼。　结果　术后矫正视力提高者 12 49眼 (...
关键词：治疗 复杂性眼外伤 临床分析 显微外科 
Evaluation of whole body reaction time and one leg with eye closed balance in elderly Japanese被引量：2
《Open Journal of Epidemiology》2012年第1期22-27,共6页Nobuyuki Miyatake Noriko Sakano Akira Yoshioka Tomohiro Hirao Takeyuki Numata 
We evaluated whole body reaction time and one leg with eye closed balance in elderly Japanese. A total of 2059 elderly Japanese (730 men and 1329 women), aged 60 - 79 years, were enrolled in the cross-sectional invest...
关键词：ELDERLY JAPANESE WHOLE Body Reaction Time ONE LEG with Eye Closed BALANCE 
Effect of light-emitting diodes with different color rendering indexes on the ocular tissues of rat被引量：2
《International Journal of Ophthalmology(English edition)》2022年第7期1035-1043,共9页Wen-Yi Chen Kun-Hong Xiao Rong Lin Ze-Ren Qiu Ya-Min Chen Ze-Qun Lin Xiu-Bin Ke Yan Huang 
Supported by the Natural Science Foundation of Fujian Province(No.2020J01652);the Undergraduate Innovation and Entrepreneurship Training Program of Fujian Medical University(No.YC2003)。
AIM:To compare the damage of light-emitting diodes(LEDs)with different color rendering indexes(CRIs)to the ocular surface and retina of rats.METHODS:Totally 20 Sprague-Dawley(SD)rats were randomly divided into four gr...
关键词：light emitting diodes lacrimal gland RETINA dry eye color rendering indexes SPECTRUM 
Mesenchymal stem cell-derived exosomes as new remedy for the treatment of inflammatory eye diseases
《BIOCELL》2022年第10期2195-2200,共6页CARL RANDALL HARRELL ANA VOLAREVIC DRAGICA PAVLOVIC VALENTIN DJONOV VLADISLAV VOLAREVIC 
This work was supported by European Crohn’s and Colitis Organization(ECCO)(Grant“The role of galectin 3 in acute colitis”),Serbian Ministry of Science(Grant Nos.ON175069 and ON175103);Faculty of Medical Sciences University of Kragujevac(Grant No.MP01/18).
Detrimental immune response has a crucially important role in the development and progression of inflammatory eye diseases.Inflammatory mediators and proteolytic enzymes released by activated immune cells induce serio...
关键词：Mesenchymal stem cells EXOSOMES INFLAMMATION Eye THERAPY 
Eye contact and sociability data suggests that Australian dingoes were never domesticated
《Current Zoology》2022年第4期423-431,共9页J William O Ballard Chloe Gardner Lucille Ellem Sonu Yadav Richard I Kemp 
supported by Australian Research Council Discover Project 150102038.
Dogs were the first animal to become domesticated by humans,and they represent a classic model system for unraveling the processes of domestication.We compare Australian dingo eye contact and socialization with Basenj...
关键词：Basenji DINGO DOMESTICATION German Shepherd dog eye gaze SOCIABILITY 
Sleep Disturbance in Parkinson’s Disease Varies with Age of Onset and Family History
《Advances in Parkinson's Disease》2016年第4期103-117,共7页Divya Madhusudhan Daniella Sisniega Andrew Ferree Janice Weinberg Marie Saint-Hilaire Samuel Ellias Anna DePold Hohler 
Introduction: Parkinson’s disease (PD) is a progressive neurodegenerative disease more common in those over the age of 60. PD is classically characterized by motor features, although patients may also experience non-...
关键词：Parkinson’s Disease (PD) Sleep Disorders Rapid Eye Movement Behavior Disorder (RBD) Age Non-Motor Symptoms Familial PD 
Model eye tool for retinal optical coherence tomography instrument calibration被引量：2
《Journal of Innovative Optical Health Sciences》2021年第3期60-67,共8页Hongting Wang Wenli Liu Zhixiong Hu Xiuyu Li Fei Li Liangcheng Duan 
The study was funded by the National Key R&D Program of China(2016YFF0201005);China Post-doctoral Science Foundation(2019M660755);Quality Infrastructure Improvement Project(ANL2001).
Optical coherence tomography(OCT)has been extensively used as noninvasive tool for biological tissues owing to its three-dimensional imaging ability and high axial resolution.OCT quality assurance is vital in these oc...
关键词：Optical coherence tomography model eye microsphere-embedded phantom 
羟基磷灰石眼座植入后钻孔的临床研究
《眼科》2001年第1期30-31,共2页宋斗 肖震国 苏书 
目的 :评价羟基磷灰石眼座植入后钻孔手术的疗效。方法 :146例HA植入 6个月后行钻孔手术。用弧形视野计测量术前、术后义眼的活动度。结果 :义眼的活动幅度从术前的 18 7± 3 8度提高到 42 3± 3 7度。随访 1～ 40个月无继发感染等并...
关键词：羟基磷灰石类 治疗应用 人工眼 
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