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检索条件："关键词=Parkinson’s "
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Replacing what’s lost: a new era of stem cell therapy for Parkinson’s disease被引量：4
《Translational Neurodegeneration》2020年第1期10-19,共10页Yong Fan Winanto Shi-Yan Ng 
This work is supported by the Third Affiliated Hospital of Guangzhou Medical University;as well as partially supported by National Medical Research Council(Singapore):NMRC/OFYIRG/2016/11.
Background Stem cells hold tremendous promise for regenerative medicine because they can be expanded infinitely,giving rise to large numbers of differentiated cells required for transplantation.Stem cells can be deriv...
关键词：Parkinson’s disease Induced PLURIPOTENT stem cells Cell therapy REGENERATIVE medicine 
Common genetic variants associated with risk of Parkinson’s disease in non-European populations:A PROSPERO registered systematic review based on genome-wide association studies
《LabMed Discovery》2024年第2期17-26,共10页Júlio César Claudino dos Santos Howard Lopes Ribeiro Junior Jackson Frederico Pires Gabriela Braga Cabrera Mano Fabricyo de Faria Esposito Dias João Vitor Caetano Goes Camilla Teixeira Pinheiro Gusmão André Rodrigues da Cunha Barreto-Vianna Ettore José Filippi Carlo Tayenne Nélly de Lucena Viana Camila de Almeida Lins Jonas Nogueira Ferreira Maciel Gusmão Renata Ferreira de Carvalho Leitão 
Howard Lopes Ribeiro Junior is recipient of a CNPq Research Productivity Scholarship-Level 2(Project:Chamada CNPq Nº09/2023-Bolsas de Produtividade em Pesquisa-PQ#305659/2023-5);funded by the Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnol ógico(FUNCAP)(UNI-0210-00007.01.00/23)entitled:“Estabelecimento de um Escore de Risco Poligênico(PRS)para a Neoplasia Mielodispl ásica no idoso:uma coorte Brasileira.
Parkinson’s disease(PD)is a complex genetic neurodegenerative disorder.Epidemiology genetic discoveries have increased our understanding of the molecular contributors to Parkinson’s pathophysiology,especially when a...
关键词：Genome-wide association studies Common variants RISK Parkinson’s disease 
A core-satellite-like nanoassembly reverses a decisive tyrosine hydroxylase loss in degenerative dopaminergic neurons
《Nano Research》2023年第7期9835-9847,共13页Ke Yao Jiamin Gan Di Zhao Mingding Li Xiaoquan Shen Yumin Yang Peijian Feng Qundong Shen 
This work was supported by National Natural Science Foundation of China(Nos.22175085 and 21875101);National Key Research and Development Program of China(No.2017YFA0701301);State Key Laboratory of Analytical Chemistry for Life Science(No.SKLACLS2219).
In recent years,neurodegenerative diseases,such as Parkinson’s or Alzheimer’s diseases,are rapidly rising in prevalence.The main hallmark of Parkinson’s disease is the falling levels of neurotransmitter dopamine in...
关键词：neurodegenerative disease dopaminergic neurons tyrosine hydroxylase APOFERRITIN Parkinson’s disease 
MTERF3 contributes to MPP+-induced mitochondrial dysfunction in SH-SY5Y cells被引量：2
《Acta Biochimica et Biophysica Sinica》2022年第8期1113-1121,共9页Shun Zhu Nan Xu Yanyan Han Xiaofei Ye Ling Yang Ji Zuo Wen Liu 
the grant from the National Natural Science Foundation of China(No.81970182)。
Parkinson’s disease(PD)is a neurodegenerative disorder causing severe social and economic burdens.The origin of PD has been usually attributed to mitochondrial dysfunction.To this end,mitochondrial transcription regu...
关键词：MTERF3 mitochondrial dysfunction degenerative disease environmental toxins Parkinson’s disease 
Distinction of an Assortment of Deep Brain Stimulation Parameter Configurations for Treating Parkinson’s Disease Using Machine Learning with Quantification of Tremor Response through a Conformal Wearable and Wireless Inertial Sensor
《Advances in Parkinson's Disease》2020年第3期21-39,共19页Robert LeMoyne Timothy Mastroianni Donald Whiting Nestor Tomycz 
Deep brain stimulation offers an advanced means of treating Parkinson’s disease in a patient specific context. However, a considerable challenge is the process of ascertaining an optimal parameter configuration. Impe...
关键词：Parkinson’s Disease Deep Brain Stimulation Wearable and Wireless Systems Conformal Wearable Machine Learning Inertial Sensor ACCELEROMETER Wireless Accelerometer Hand Tremor Cloud Computing Network Centric Therapy Python 
Macroautophagy in sporadic and the genetic form of Parkinson’s disease with the A53T asynuclein mutation被引量：1
《Translational Neurodegeneration》2012年第1期4-10,共7页Yue Huang Fariba Chegini Germaine Chua Karen Murphy Weiping Gai Glenda M Halliday 
This study was financially supported by NHMRC project grant 510186;by a Goldstar Award from the University of New South Wales.GMH has a NHMRC Senior Principal Research Fellowship(630434);WPG has a NHMRC Senior Research Fellowship(535014).
Background:The A53T mutation in the a-synuclein gene causes autosomal-dominant Lewy body Parkinson’s disease(PD).Cultured cell models have linked this mutation to increased cell macroautophagy,although evidence of en...
关键词：Α-SYNUCLEIN MACROAUTOPHAGY Parkinson’s disease 
Concomitant Othello syndrome and impulse control disorders in a patient with Parkinson’s disease:A case report
《World Journal of Clinical Cases》2022年第3期1024-1031,共8页Tian Xu Zhao-Sheng Li Wei Fang Lan-Xiao Cao Guo-Hua Zhao 
Supported by Zhejiang Province Medical Science and Technology Project,No.2018KY872;Yiwu Science and Technology Bureau Project,No.20-3-074.
BACKGROUND Othello syndrome(OS)is characterized by delusional beliefs concerning the infidelity of a spouse or sexual partner,which may lead to extreme behaviors.Impulse control disorders refer to behaviors involving ...
关键词：Othello syndrome Delusional jealousy Impulse control disorders Hypersexuality Parkinson’s disease Case report 
Transcriptome profiling of 6-OHDA model of Parkinson’s disease
《Advances in Bioscience and Biotechnology》2013年第6期28-35,共8页Maria I. Shadrina Elena V. Filatova Anelya Kh. Alieva Alla V. Stavrovskaya Rudolph M. Khudoerkov Svetlana A. Limborska Sergei N. Illarioshkin Petr A. Slominsky 
Analysis of monogenic forms and candidate genes of Parkinson’s disease (PD) does not allow to describe completely the contribution of genetic factors to the etiopathogenesis of the disorder. An approach associated wi...
关键词：6-OHDA Parkinson’s DISEASE TRANSCRIPTOME 
Transforming growth factor β1-mediated anti-inflammation slows progression of midbrain dopaminergic neurodegeneration in Parkinson's disease?
《Neural Regeneration Research》2015年第10期1578-1580,共3页Björn Spittau 
Parkinson’s disease（PD）is characterized by the progressive loss of midbrain dopaminergic（m DA）neurons and a subsequent decrease in striatal dopamine levels,which cause the typical clinical motor symptoms such as ...
关键词：Transforming growth factor mediated anti-inflammation slows progression of midbrain dopaminergic neurodegeneration in Parkinson’s disease TGF 
Real world studies are essential for drug therapy in Parkinson's disease
《Neural Regeneration Research》2018年第9期1544-1545,共2页Thomas Müller 
Prospective real-world data from large patient samples, which re- port on the long-term effectiveness of the employed different drug therapies, are rare in Parkinson＇s disease （PD）. The non interven- tional ＂Trans...
关键词：RCT Real world studies are essential for drug therapy in Parkinson’s disease PDQ 
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