3,4二氢2H苯并[b][1,4]二氧杂环庚7醇的结构鉴定及抗氧化性研究  

Structure identification and antioxidation activity of3,4- Dihydro-2H- benzo[b][1,4]dioxepin-7- ol

作　　者：罗忠明[1] 刘柳[1] 逯与运[1] 孙元奎[1] 晏日安[1] 

机构地区：[1]暨南大学食品科学与工程系,广东广州510632

出　　处：《食品工业科技》2015年第11期214-218,共5页Science and Technology of Food Industry

基　　金：广州市科技计划项目(11C12070753)资助

摘　　要：以邻苯二酚、1,3-二溴丙烷为起始原料,在碱性回流条件下经环化反应得到3,4-二氢-2H-1,5-苯并二氧环丙,然后通过Friedel-Crafts酰基化反应得到7-乙酰基-3,4-二氢-1,5-苯并二恶庚,之后经Bayer-Villiger氧化、水解酸化及柱层析分离得到目标产物,总产率28.5%。采用红外光谱(IR)、质谱(MS)以及核磁共振(1H-NMR,13C-NMR)对终产物进行结构鉴定,确定目标产物为3,4-二氢-2H-苯并[b][1,4]二氧杂环庚-7-醇。测定其在油脂中的抗氧化能力,结果表明其在动植物油脂中均具有一定的抗氧化性。With catechol and 1, 3- Dibromopropan as starting materials, 3,4- Dihydro-2 H- 1, 5 - benzodioxepin was prepared by cyclization reaction under the condition of alkaline reflux,then through FriedeI-Crafts acylation to get 1 - (3,4- dihydro-2H- 1,5 - benzodioxepin- 7 - yl ) ethan-1 - one. Followed by Bayer- Villiger oxidation, hydrolytic acidification and column chromate graphy separation,the final product was obtained and the yield was 28.5%. Using Infrared spectroscopy,mass spectrometry and nuclear magnetic resonance spectroscopy(^1H-NMR,^13C- NMR) for structure identification and characterization, the final product was identified as 3,4- Dihydro-2H-benzo [ b] [ 1 ,4] dioxepin-7-oI.Antioxidation activity in oils was evaluated.Results showed that the product had a certain antioxidation activity in both animal and vegetable oils.

关 键 词：芝麻酚 3 4-二氢-2H-苯并[b][1 4]二氧杂环庚-7-醇 Friedel-Crafts酰基化 抗氧化 

分 类 号：TS202.3[轻工技术与工程—食品科学]