植物多酚通过Nrf2/ARE信号通路抗氧化作用研究进展  

Plant Polyphenols Exert Antioxidant Activity of by Nrf2/ARE Signaling Pathway: A Review

作　　者：廖霞[1] 郑少杰[1] 卢可可[1] 肖星凝 吴素蕊[2] 明建[1,3] 

机构地区：[1]西南大学食品科学学院,重庆400715 [2]中华全国供销合作总社昆明食用菌研究所,云南昆明650223 [3]重庆市特色食品工程技术研究中心,重庆400715

出　　处：《食品科学》2016年第7期227-232,共6页Food Science

基　　金：国家自然科学基金面上项目(31471576);"十二五"国家科技支撑计划项目(2013BAD16B01);中央高校基本科研业务费专项资金项目(XDJK2015D035)

摘　　要：植物多酚是植物体内重要的次生代谢产物,是重要的天然抗氧化剂,能够清除自由基和淬灭活性氧。Nrf2(NF-E2-related factor 2)/抗氧化反应元件(antioxidant response element,ARE)信号通路是增强机体抗氧化功能最重要的保护性信号途径,在细胞抵御氧化应激机制中有着重要的地位,是抗氧化研究领域的热点。本文综述了Nrf2/ARE信号通路的组成及其调节机制,总结植物多酚通过该信号通路增强机体抗氧化应激能力,减少细胞凋亡、参与神经保护、延缓衰老和减少氧化损伤等的能力,以期为植物多酚应用于抗氧化保健食品和药品的开发提供一定依据。Polyphenols are important secondary metabolites widely distributed in the plant kingdom. They are well known as antioxidants which reduce ROS-induced damage and scavenge free radicals. The Nrf2/ARE signaling pathway is one of the most important pathways involved in preservation of antioxidant activity and defense against oxidative stress re lease in cells. This review outlines the composition and modulatory mechanism of the Nrf2/ARE signaling pathway. Plant polyphenols enhance oxidative stress resistance, reduce apoptosis, provide nerve protection, resist aging and mitigate oxidative damage through the Nrf2/ARE signaling pathway. All these evidence suggests that plant polyphenols have great potentials to be utilized in foods and drugs.

关 键 词：植物多酚 Nrf2/ARE 信号通路 抗氧化活性 

分 类 号：Q964.8[生物学—昆虫学] R151.2[医药卫生—营养与食品卫生学]