Epigenetic targets of rheumatoid arthritis  

作　　者：Ghazi Chabchoub 

机构地区：[1]Laboratoire de Génétique Moléculaire Humaine,Faculté de Médecine de Sfax [2]Caisse National d’assurance Maladie

出　　处：《World Journal of Rheumatology》2015年第3期127-130,共4页世界风湿病学杂志

摘　　要：Rheumatoid arthritis(RA) is a systemic,inflammatory and autoimmune disorder,characterized by chronic arthritis with progressive joint destruction.It has a multifactorial aetiology involving both genetic and environmental factors.Epigenetics can be defined as modifications of DNA that result in altered gene expression.The two main epigenetic mechanisms are post translational modifications to histone tails and DNA methylation.Recent evidence has suggested that epigenetic mechanisms may be an important contributor to RA susceptibility.The aim of this editorial is to present evidence for the role of epigenetic mechanisms in the pathogenesis of RA and the potential to therapeutic target.Several studies targeting histone modification and DNA methylation in animal models of inflammatory arthritis will be reviewed and alterations in the epigenetic signature of genes of key RA related pathways such as pro-inflammatory cytokines,proteases and regulators of cellular proliferation.Rheumatoid arthritis(RA) is a systemic,inflammatory and autoimmune disorder,characterized by chronic arthritis with progressive joint destruction.It has a multifactorial aetiology involving both genetic and environmental factors.Epigenetics can be defined as modifications of DNA that result in altered gene expression.The two main epigenetic mechanisms are post translational modifications to histone tails and DNA methylation.Recent evidence has suggested that epigenetic mechanisms may be an important contributor to RA susceptibility.The aim of this editorial is to present evidence for the role of epigenetic mechanisms in the pathogenesis of RA and the potential to therapeutic target.Several studies targeting histone modification and DNA methylation in animal models of inflammatory arthritis will be reviewed and alterations in the epigenetic signature of genes of key RA related pathways such as pro-inflammatory cytokines,proteases and regulators of cellular proliferation.

关 键 词：RHEUMATOID ARTHRITIS EPIGENETIC DNA METHYLATION HISTONE modification 

分 类 号：R[医药卫生]