Pro-and anti-epileptic roles of microglia  

作　　者：Shinichi Kinoshita Ryuta Koyama 

机构地区：[1]Laboratory of Chemical Pharmacology,Graduate School of Pharmaceutical Sciences,The University of Tokyo,Tokyo,Japan

出　　处：《Neural Regeneration Research》2021年第7期1369-1371,共3页中国神经再生研究（英文版）

基　　金：supported in part by a Grant-in-Aid for Scientific Research (B)(17H03988 to RK) from JSPS and JST PRESTO (JPMJPR18H4 to RK)。

摘　　要：Microglia are brain-resident immune cells that contribute to the maintenance of brain homeostasis.In the epileptic brain, microglia show various activation phenotypes depending on the stage of epileptogenesis.Therefore, it remains unclear whether microglial activation acts in a pro-epileptic or anti-epileptic manner.In mesial temporal lobe epilepsy, one of the most common form of epilepsies, microglia exhibit at least two distinct morphologies, amoeboid shape and ramified shape.Amoeboid microglia are often found in sclerotic area, whereas ramified microglia are mainly found in non-sclerotic area;however, it remains unclear whether these structurally distinct microglia share separate roles in the epileptic brain.Here, we review the roles of the two distinct microglial phenotypes, focusing on their pro-and anti-epileptic roles in terms of inflammatory response, regulation of neurogenesis and microglia-neuron interaction.

关 键 词：EPILEPSY EPILEPTOGENESIS inflammatory cytokines MICROGLIA NEUROGENESIS neuron-microglia interaction SEIZURE 

分 类 号：R742.1[医药卫生—神经病学与精神病学]