Regulation of Intestinal Cholesterol Absorption: A Disease Perspective  

作　　者：Jahangir Iqbal Ali Al Qarni Abbas Hawwari 

机构地区：[1]King Abdulaziz Medical City Hospital, Al Ahsa, KAIMRC, MNGHA, Saudi Arabia

出　　处：《Advances in Biological Chemistry》2017年第1期60-75,共16页生物化学进展（英文）

摘　　要：Hypercholesterolemia promotes atherosclerosis and precise regulation of cholesterol homeostasis is essential. Besides risk factor for cardiovascular disease, abnormalities in cholesterol metabolism have been associated with type 2 diabetes. Cholesterol homeostasis in the body is maintained by de novo synthesis. Furthermore, intestinal cholesterol absorption has recently been considered as an important control point in cholesterol homeostasis. Important insights have been gained into the mechanisms of transport of cholesterol from the intestinal lumen into the enterocytes. Several transporter proteins that appear to be key players in the control of the cholesterol absorption from the intestinal lumen have been identified. Here, we review intestinal cholesterol absorption and the mechanisms underlying alterations in cholesterol absorption under physiological conditions and in diseases such as diabetes mellitus.Hypercholesterolemia promotes atherosclerosis and precise regulation of cholesterol homeostasis is essential. Besides risk factor for cardiovascular disease, abnormalities in cholesterol metabolism have been associated with type 2 diabetes. Cholesterol homeostasis in the body is maintained by de novo synthesis. Furthermore, intestinal cholesterol absorption has recently been considered as an important control point in cholesterol homeostasis. Important insights have been gained into the mechanisms of transport of cholesterol from the intestinal lumen into the enterocytes. Several transporter proteins that appear to be key players in the control of the cholesterol absorption from the intestinal lumen have been identified. Here, we review intestinal cholesterol absorption and the mechanisms underlying alterations in cholesterol absorption under physiological conditions and in diseases such as diabetes mellitus.

关 键 词：CHOLESTEROL Absorption ATHEROSCLEROSIS METABOLIC DISEASE NPC1L1 ATP-BINDING CASSETTE Transporters 

分 类 号：R5[医药卫生—内科学]