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医药卫生: 作品数：15372335被引量：10125488H指数：549; 导出分析报告; 相关作者：王伟胡大一李静张伟李莉更多>>; 相关机构：复旦大学华中科技大学第二军医大学山东大学更多>>; 发文主题：护理疗效观察疗效临床疗效儿童更多>>; 相关期刊：更多>>; 发文基金：国家自然科学基金国家重点基础研究发展计划国家科技重大专项广东省自然科学基金更多>>

Activation of endogenous neurogenesis and angiogenesis by basic fibroblast growth factor-chitosan gel in an adult rat model of ischemic stroke被引量：6: 《Neural Regeneration Research》2024年第2期409-415,共7页Hongmei Duan Shulun Li Peng Hao Fei Hao Wen Zhao Yudan Gao Hui Qiao Yiming Gu Yang Lv Xinjie Bao Kin Chiu Kwok-Fai So Zhaoyang Yang Xiaoguang Li; supported by the National Natural Science Foundation of China,Nos.81941011(to XL),31771053(to HD),31730030(to XL),31971279(to ZY),31900749(to PH),31650001(to XL),31320103903(to XL),31670988(to ZY);the Natural Science Foundation of Beijing,Nos.7222004(to HD);a grant from Ministry of Science and Technology of China,Nos.2017YFC1104002(to ZY),2017YFC1104001(to XL);a grant from Beihang University,No.JKF-YG-22-B001(to FH)。; Attempts have been made to use cell transplantation and biomaterials to promote cell proliferation,differentiation,migration,and survival,as well as angiogenesis,in the context of brain injury.However,whether bioactiv...; 关键词：adult endogenous neurogenesis ANGIOGENESIS basic fibroblast growth factor-chitosan gel CHITOSAN functional recovery ischemic stroke neural stem cell newborn neuron

牵牛子化学拆分组分影响上焦水饮内停模型大鼠药效学研究: 《中药药理与临床》2023年第6期70-75,共6页徐静孙延平高宁王宇梁华王秋红匡海学; 国家重点基础研究发展计划(973计划)项目(编号:2013CB531801);国家自然科学基金资助项目(编号:81473563);国家自然科学基金青年科学基金项目(编号:81503271);黑龙江省自然科学基金项目(编号:JJ2022LH1048);黑龙江省中医药经典普及化研究专项课题(编号:ZYW2023-003、ZYW2022-066);黑龙江省博士后科研启动金资助项目(编号:LBH-Q21045)。; 目的:探讨牵牛子水煎液及化学拆分组分对大鼠上焦水饮内停模型药效学研究,寻找牵牛子对上焦水饮内停模型作用的药效物质基础。方法:采用复合造模因素(大鼠腹部皮下注射异丙肾上腺素+气管插管+寒冷刺激)建立上焦水饮内停模型。模型建立...; 关键词：牵牛子树脂苷多糖上焦水饮内停模型异丙肾上腺素

商陆不同组分对上焦水饮内停大鼠模型药效学研究: 《中药药理与临床》2023年第5期96-100,共5页徐静李晓亮高宁梁华王秋红匡海学; 国家重点基础研究发展计划(973计划)项目(编号:2013CB531801);国家重点研发计划项目(编号:2019YFC1708801);广东省重点领域研发计划(编号:2020B1111120002);国家自然科学基金资助项目(编号:81473563);国家自然科学基金青年科学基金项目(编号:81503271);国家自然科学基金资助项目(编号:82160702);黑龙江省自然科学基金项目(编号:JJ2022LH1048);海南省自然科学基(编号:Hnky2019ZD-24)。; 目的:探讨商陆水煎液及不同组分对大鼠上焦水饮内停模型药效学研究,寻找商陆对上焦水饮内停模型作用的药效物质基础。方法:采用复合造模因素(大鼠腹部皮下注射异丙肾上腺素+气管插管+寒冷刺激)建立上焦水饮内停模型,模型建立后开始给予...; 关键词：商陆多糖上焦水饮内停模型异丙肾上腺素

Cardiac patches made of brown adipose-derived stem cell sheets and conductive electrospun nanofibers restore infarcted heart for ischemic myocardial infarction被引量：2: 《Bioactive Materials》2023年第9期271-287,共17页Xinbo Wei Li Wang Cuimi Duan Kai Chen Xia Li Ximin Guo Peng Chen Haifeng Liu Yubo Fan; supported by the National Natural Science Foundation of China(32071359,11827803,61227902,and U20A20390);National Key Technology R&D Program(2020YFC0122203);International Joint Research Center of Aerospace Biotechnology and Medical Engineering from Ministry of Science and Technology of China;111 Project(B13003);Research Fund for the Doctoral Program of Higher Education of China(20131102130004);Fundamental Research Funds for the Central Universities.; Cell sheet engineering has been proven to be a promising strategy for cardiac remodeling post-myocardial infarction. However, insufficient mechanical strength and low cell retention lead to limited therapeutic efficie...; 关键词：Myocardial infarction brown adipose-derived stem cells Cell sheet engineering Electrospun nanofibers Polycaprolactone/silk fibroin Carbon nanotubes

薏苡仁及其组分对佐剂性关节炎大鼠抗炎镇痛的作用及其机制被引量：16: 《中国组织工程研究》2023年第26期4187-4192,共6页岳静王世军; 国家科学技术部“973”计划项目(2013CB531803),项目负责人:王世军。; 背景:类风湿性关节炎是一种自身免疫性疾病,以关节炎症及疼痛为主要症状,属中医痹症范畴。以薏苡仁为主的方剂为除痹经典方,但起效组分及其机制尚不清楚。目的:探讨观薏苡仁及其组分对佐剂性关节炎大鼠的抗炎作用及其作用机制,寻找薏苡...; 关键词：薏苡仁有效组分佐剂性关节炎动物模型炎性因子大鼠

Size-transformable nanoparticles with sequentially triggered drug release and enhanced penetration for anticancer therapy: 《Nano Research》2023年第8期11186-11196,共11页Yulin Li Liudi Wang Guoqiang Zhong Guoying Wang Yanzhao Zhu Jian Li Lan Xiao Yanhui Chu Yan Wu Kaichun Li Jie Gao; supported by the National Basic Research Program of China(973 Program,No.2012CB933600);the National Natural Science Foundation of China(Nos.81771964 and 82072051);the Shanghai Municipal Natural Science Foundation(No.15ZR1408500);funded by the Special Project of Clinical Research of Health Industry of Shanghai Municipal Health Commission(No.201940178);the Scientific Research Project of Hongkou District Health Committee of Shanghai(No.2002-17);the Clinical Research Project of Wu Jieping Medical Foundation(No.320.6750.2020-18-2);the Research Project of Shanghai Fourth People’s Hospital(No.sykyqd 00701&00702).; There are several limitations to the application of nanoparticles in the treatment of cancer,including their low drug loading,poor colloidal stability,insufficient tumor penetration,and uncontrolled release of the dru...; 关键词：sequentially triggered drug release size-transformable NANOPARTICLES tumor penetration anticancer therapy drug delivery

前列腺癌患者生存质量的影响因素分析: 《成都医学院学报》2023年第4期434-438,共5页奉琴杨璐刘玲汪宇胥国薇陈叶; 国家重点基础研究发展计划(No:2017YFC0908003);四川大学华西护理学科发展专项基金(No:HXHL19020)。; 目的调查分析影响前列腺癌患者生存质量的因素,为前列腺癌患者生存质量的全面管理提供依据。方法采用方便抽样法,选取2020年3—9月于四川大学华西医院泌尿外科拟接受根治性前列腺癌切除术的108例患者为研究对象。通过一般资料调查表...; 关键词：前列腺癌勃起功能生存质量希望水平全面管理

Prevention strategies of postoperative adhesion in soft tissues by applying biomaterials:Based on the mechanisms of occurrence and development of adhesions被引量：7: 《Bioactive Materials》2023年第8期387-412,共26页Jie Liao Xiaoming Li Yubo Fan; financial support from the National Natural Science Foundation of China(Nos.32171345,T2288101,U20A20390,and 11827803);Fok Ying Tung Education Foundation(No.141039);International Joint Research Center of Aerospace Biotechnology and Medical Engineering,Ministry of Science and Technology of China,the 111 Project(No.B13003);the Academic Excellence Foundation of BUAA for PhD Students.; Postoperative adhesion(POA)widely occurs in soft tissues and usually leads to chronic pain,dysfunction of adjacent organs and some acute complications,seriously reducing patients’quality of life and even being life-t...; 关键词：Prevention of postoperative adhesions(POA) Soft tissues Mechanisms of occurrence and development BIOMATERIALS

International Nuclear Medicine Consensus on the Clinical Use of Amyloid Positron Emission Tomography in Alzheimer’s Disease被引量：6: 《Phenomics》2023年第4期375-389,共15页Mei Tian Chuantao Zuo Ali Cahid Civelek Ignasi Carrio Yasuyoshi Watanabe Keon Wook Kang Koji Murakami Valentina Garibotto John OPrior Henryk Barthel Yihui Guan Jiaying Lu Rui Zhou Chentao Jin Shuang Wu Xiaohui Zhang Yan Zhong Hong Zhang Molecular Imaging-Based Precision Medicine Task Group of A3(China-Japan-Korea)Foresight Program; This study was partially sponsored by the National Natural Science Foundation of China(NSFC)(81761148029,81725009,82030049,82021002,81971641);Ministry of Science and Technology of China(MOST)(2021YFA110004500,2021YFE0108300);Clinical Research Plan of SHDC(SHDC2020CR1038B);Science and Technology Innovation 2030 Major Projects(2022ZD0211600);Swiss National Science Foundation(project nos.185028,188355,and 169876);National Research Foundation of Korea(NRF-2017K2A9A2A10013554).; Alzheimer’s disease(AD)is the main cause of dementia,with its diagnosis and management remaining challenging.Amyloid positron emission tomography(PET)has become increasingly important in medical practice for patients...; 关键词：Positron emission tomography(PET) Alzheimer’s disease AMYLOID Brain imaging Expert consensus

A Novel CA4P Polymeric Nanoparticle for Murine Hepatoma Therapy: 《Chinese Journal of Polymer Science》2023年第8期1223-1229,I0007,共8页Zhi-Lin Liu Xi-Tong Ren Yue Huang Jia-Li Sun Xiao-Shuang Wang Meng-Fei Zheng Lin-Jie Cui Xue-Fei Zhang Zhao-Hui Tang; financially supported by the Ministry of Science and Technology of China(No.2022YFE0110200);the Natural Science Foundation of Hunan Province of China(No.2021JJ30680);the National Natural Science Foundation of China(Nos.52203198,52025035 and 52103195)。; Combretastatin A4 phosphate(CA4P)is a potent vascular disrupting agent with good water solubility.However,it is only effective at high doses,which decreases clinical applicability.Herein,we designed stable CA4P polyme...; 关键词：CA4P polymeric nanoparticle Cholesterol derivatives Vascular disrupting agent Phosphate-guanidine coordination Drug controlled release

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