云南高校图书馆联盟文献共享服务平台- 国家自然科学基金(81230090)

国家自然科学基金(81230090): 作品数：16被引量：63H指数：4; 导出分析报告; 相关作者：张卫东叶霁孙青龑柳润辉林生更多>>; 相关机构：第二军医大学华东理工大学上海中医药大学中国医学科学院北京协和医学院更多>>; 相关期刊：《Chinese Herbal Medicines》《Chinese Journal of Natural Medicines》《Acta Pharmacologica Sinica》《有机化学》更多>>; 相关主题：APOPTOSISTRITERPENOIDSGENOMICSTRADITIONAL_CHINESE_MEDICINEOVERVIEW更多>>; 相关领域：医药卫生理学化学工程生物学更多>>

3,4-Secocycloartane Triterpenoids from the Cones of Pseudolarix amabilis: 《Natural Products and Bioprospecting》2021年第1期119-126,共8页Si-Jia Xiao Bo Li Zheng-Rui Huang Wen-Lin Yuan Ji Ye Hui-Liang Li Xi-Ke Xu Yun-Heng Shen Wei-Dong Zhang; supported by NSFC(31870327,81230090,81520108030,1302658);National Major Project of China(2018ZX09731016-005);The Key Research and Development Program of China(2017YFC1702002,2017YFC1700200);Professor of Chang Jiang Scholars Program,Scientific Foundation of Shanghai China(17431902800,16401901300);Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products(10DZ2251300).; Four new 3,4-secocycloartane triterpenoids,pseudolactones A-D(1-4),were isolated from the ethanol extract of the cones of Pseudol arixamabilis.Their structures were established by extensive 1D-and 2D-NMR experiments.T...; 关键词：Pseudol arixamabilis TRITERPENOIDS 3 4-Secocycloartane Pseudolactones A-D

Triterpenoids from Ainsliaea latifolia and Their Cyclooxyenase‑2(COX‑2)Inhibitory Activities被引量：2: 《Natural Products and Bioprospecting》2020年第1期13-21,共9页Wen-Lin Yuan Xue-Yun Dong Zheng-Rui Huang Si-Jia Xiao Ji Ye Xin-Hui Tian Hui-Liang Li Yun-Heng Shen Wei-Dong Zhang; supported by NSFC(Nos.81573318,31870327,81230090,81520108030,1302658);National Major Project of China(No.2018ZX09731016-005);The Key Research and Development Program of China(Nos.2017YFC1702002,2017YFC1700200);Professor of Chang Jiang Scholars Program,Scientific Foundation of Shanghai China(Nos.17431902800,16401901300);Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products(No.10DZ2251300).; Eight new triterpenoids were isolated from Ainsliaea latifolia.The structures of these compounds were elucidated by interpretation of spectroscopic data,including HRESIMS and NMR data.Compounds 4–6 are identifed as r...; 关键词：Ainsliaea latifolia TRITERPENOIDS COX-2 Cucurbitane

Exploring pathogenesis in subjects with subjective Tinnitus having kidney deficiency pattern in terms of Traditional Chinese Medicine based on serum metabolic profiles被引量：2: 《Journal of Traditional Chinese Medicine》2018年第5期773-780,共8页Tan Yong Shen Shanshan Guan Fulan He Bing Lu Cheng Xiao Cheng Jiang Miao Zhao Ning Li Li Cheng Shiping Zu Xianpeng Zhang Weidong Liu Xinru Lü Aiping; Supported by China Scholarship Council Fund(No.201609110029);Hong Kong Baptist University Strategic Development Fund(No.SDF13-1209-P01);National Natural Science Foundation of China(No.81230090 and 1302658);Fundamental Research Funds for the Central Public Welfare Research Institutes in China(No.Z0558);The Open Project of State Key Laboratory of Innovative Natural Medicine and TCM Injections(No.QFSKL2018003);Beijing TCM Science and Technology Development Fund Project(No.JJ2018-102); OBJECTIVE: To investigate the metabolic pathogenesis in subjects with subjective tinnitus(ST)having kidney deficiency pattern(KDP)(ST/KDP) in terms of Traditional Chinese Medicine.METHODS: Three groups of subjects, in...; 关键词：SUBJECTIVE TINNITUS Kidney DEFICIENCY PATTERN PATHOGENESIS Metabolic profile

蜘蛛香乙酸乙酯部位化学成分的研究被引量：3: 《中国中药杂志》2018年第1期100-108,共9页林生付芃沈云亨叶霁张中晓杨献文李慧梁柳润辉徐希科张卫东; 国家自然科学基金项目(81522050,81230090,81520108030,21472238);上海科学基金项目(12401900801,13401900103,13401900101); 运用正相和反相硅胶柱色谱、凝胶柱色谱、大孔吸附树脂柱色谱、反相高效液相色谱等分离和纯化方法,从蜘蛛香乙酸乙酯部位中共分离得到173个化合物。应用一维和二维NMR,UV,IR,MS等波谱方法鉴定了它们的结构,化合物类型涉及环烯醚萜、倍...; 关键词：败酱科蜘蛛香化学成分细胞毒

网络生物学在中医药研究中的应用被引量：16: 《中国中药杂志》2018年第2期274-280,共7页田赛赛杨健赵静张卫东; 国家“重大新药创制”科技重大专项(2011ZX09307-002-03);国家自然科学基金项目(81230090,81520108030,21472238,61372194);上海市科委中药现代化专项(12401900801,13401900103,13401900101);上海市活性天然产物制备工程技术研究中心项目(16 DZ2280200);重庆市研究生教改项目(yjg152017); 随着人类基因组计划的完成,人们逐渐认识到生物系统的功能是通过基因、蛋白以及小分子之间的网络式相互作用完成的,同时发现复杂疾病往往是由于多个基因表达紊乱导致生物学过程失衡而产生的,这些促使了＂多靶点＂药物发现理念的兴起。...; 关键词：复杂疾病中医药多靶点药物整体观辨证论治网络生物学

Structural analysis of recombinant human ubiquitin-conjugating enzyme UbcH5c: 《Acta Pharmaceutica Sinica B》2017年第3期390-394,共5页Fangshu Wu Junsheng Zhu Honglin Li Lili Zhu; supported by the National Natural Science Foundation of China(grants 21372078,81302697 and 81230090);the National S&T Major Project of China(grant 2013ZX09507004);the Shanghai Committee of Science and Technology(grant 14431902400);the Fundamental Research Funds for the Central Universities; UbcH5c belongs to the ubiquitin-conjugating enzyme family and plays an important role in catalyzing ubiquitination during TNF-α–triggered NF-κB activation. Therefore, UbcH5c is a potent therapeutic target for the t...; 关键词：UbcH5c NF-ΚB UBIQUITINATION Ubiquitin-conjugating enzyme Crystal structure Inflammatory target

nhibition of tissue transglutaminase promotes Aβ- nduced apoptosis in SH-SY5Y cells被引量：3: 《Acta Pharmacologica Sinica》2016年第12期1534-1542,共9页JiZHANG Yi-rong DING Rui WANG; This work was supported by the grants to Rui WANG from the National Natural Science Foundation of China （No 81072627 and 81230090）, the Shanghai Committee of Science and Technology （No 12431900901）, and the 111 Project of the Chinese Ministry of Education （No B07023）.; Aim： Tissue transglutaminase （tTG） catalyzes proteins, including β-amyloid （Aβ）, to cross-link as a y-glutamyl-ε-lysine structure isopeptide, which is highly resistant to proteolysis. Thus, tTG plays an import...; 关键词：tissue transglutaminase （tTG） γ-glutamyl-ε-lysine isopeptide Alzheimer＇s disease NTU283 Β-AMYLOID SH-SY5Y cells APOPTOSIS

Application of Connectivity Map Database to Research on Chinese Materia Medica被引量：2: 《Chinese Herbal Medicines》2016年第2期117-120,共4页Chao Lv Yu-chong Wang Run-hui Liu Wei-dong Zhang; Professor of Chang Jiang Scholars Program,NSFC(81230090,81520108030); The connectivity map（CMAP） database is established initially to connect biology, chemistry, and clinical conditions, which helps to discover the connection of disease-gene-drug. The CMAP approach has been applied in...; 关键词：Chinese materia medica Chinese materia medica formula connectivity map establishing connectivity map database

Isochamaejasmin induces apoptosis in leukemia cells through inhibiting Bcl-2 family proteins被引量：9: 《Chinese Journal of Natural Medicines》2015年第9期660-666,共7页ZHANG Shou-De SHAN Lei LI Wei LI Hong-Lin ZHANG Wei-Dong; supported by the National Natural Science Foundation of China(Nos.81302651,81230090,and 81222046);the Fundamental Research Funds for the Central Universities(No.222201314041);the Global Research Network for Medicinal Plants(GRNMP);King Saud University,the Shanghai Leading Academic Discipline Project(No.B906);the Key Laboratory of Drug Research for Special Environments,PLA,the Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products(No.10DZ2251300);the Scientific Foundation of Shanghai China(Nos.12401900801,09DZ1975700,09DZ1971500,and 10DZ1971700); The biflavonoid isochamaejasmin is mainly distributed in the root of Stellera chamaejasme L.(Thymelaeaceae) that is used in traditional Chinese medicine(TCM) to treat tumors, tuberculosis, and psoriasis. Herein, isoch...; 关键词：Stellera chamaejasme L. Isochamaejasmin Bcl-2 3D Similarity search （–）-Gossypol Apoptosis

天然产物文殊兰新碱的全合成研究: 《药学实践杂志》2015年第4期331-333,共3页陈浩叶霁刘江云张卫东孙青龑; 国家自然科学基金(81230090);上海市重点学科建设项目(B906); 目的开展文殊兰新碱的全合成工作。方法以3,4-亚甲二氧基苯乙胺和2,5-二甲氧基苯乙酸为起始原料,经缩合、环合、还原和氧化等反应。结果与结论完成了文殊兰新碱的全合成,确定了其最佳合成路线,总收率为73%。; 关键词：生物碱文殊兰新碱全合成

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