国家重点基础研究发展计划(2013CB911204)

作品数:3被引量:3H指数:1
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相关作者:赵健元赵世民更多>>
相关机构:复旦大学更多>>
相关期刊:《中国科学:生命科学》《Science China Chemistry》《Journal of Genetics and Genomics》更多>>
相关主题:BINDINGROLESMETABOLITEEPIGENETICSREGULATORY更多>>
相关领域:医药卫生理学更多>>
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代谢物感知失调的分子致病机理被引量:1
《中国科学:生命科学》2016年第4期392-396,共5页赵健元 赵世民 
国家重大基础研究发展计划(批准号:2012CB910103,2013CB531200,2013CB945100,2013CB911204,2015AA020913);国家自然科学基金(批准号:31330023,81301717,81471454);科技部重大国际合作项目(批准号:2014DFA30630);上海市领军人才计划资助
代谢是最基础的生命活动.生物代谢网络由代谢酶和代谢物共同构成.相对于对代谢酶性质的深刻认识,对代谢物生理重要性的认识停留在物质代谢与能量代谢的水平.近年来,本研究组及国际上其他实验室的工作发现,代谢物具有信号传导功能.细胞...
关键词:代谢物感知 中间代谢物 信号通路 
An ultra-fast and highly efficient multiple proteases digestion strategy using graphene-oxide-based immobilized protease reagents
《Science China Chemistry》2014年第5期695-702,共8页BAI HaiHong PAN YiTing REN XiaoJun HAO FeiRan DENG ShanShan FAN Chao YAN Hui SHEN BingQuan MA Lin TIAN Fang PENG Bo DENG YuLin QIN WeiJie QIAN XiaoHong 
supported by the National Basic Research Program of China(2013CB911204);the National Key Scientific Instrument Development Program of China(2011YQ09000504);the National Natural Science Foundation of China(21275005,21235001)
Highly efficient and rapid proteolytic digestion of proteins into peptides is a crucial step in shotgun-based proteome-analysis strategy. Tandem digestion by two or more proteases is demonstrated to be helpful for inc...
关键词:graphene oxide TRYPSIN GIu-C immobilized protease multiple proteases digestion 
Regulatory Roles of Metabolites in Cell Signaling Networks被引量:2
《Journal of Genetics and Genomics》2013年第7期367-374,共8页Feng Li Wei Xu Shimin Zhao 
supported by the National Key Basic Research Programs of China(Nos.2012CB910300, 2012CB721102,2013CB911204,and 2013CB945400);the National Natural Foundation of China(No.31030042);the Shanghai Basic Research Fund(Nos.11JC1401100 and 13XD 1400500).
Mounting evidence suggests that cellular metabolites, in addition to being sources of fuel and macromolecular substrates, are actively involved in signaling and epigenetic regulation. Many metabolites, such as cyclic ...
关键词:METABOLITE Signaling Modification BINDING EPIGENETICS 
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